Category: 1190320-33-2

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1190320-33-2, name is 6-Fluoro-1H-pyrrolo[3,2-b]pyridine, molecular formula is C7H5FN2, molecular weight is 136.13, as common compound, the synthetic route is as follows.name: 6-Fluoro-1H-pyrrolo[3,2-b]pyridine

Step 3: l-(6-Fluoro-lH-pyrrolo[3,2-b]pyridin-3-yl)-N,N-dimethylmethanamine (25) 25 [00632] Paraformaldehyde (0.24 g, 8.1 mmol) and dimethylamine hydrochloride (0.66 g, 8.1 mmol) were added to a stirred solution of compound 24 (1.0 g, 7.35 mmol) in n-butanol (10 mL). The reaction was refluxed for 3 h. The solution was allowed to cool to rt and poured into 15% HCl (100 mL). The butanol layer was discarded and the water phase was adjusted to pH13- 14 with 2M NaOH. The resulting mixture was extracted with ethyl acetate (100 mLx3). The organic extracts were combined, washed with brine (100 mL), dried over anhydrous sodium sulfate, and concentrated to give compound 25 (1.0 g, 71% yield), which was used in the next reaction without purification. LC-MS: 194.02 (M+H), Ci0Hi2FN3. 1H NMR (CDC13, 400 MHz) S: 10.13 (br, 1H), 8.36 (s, 1H), 7.31-7.22 (m, 2H), 3.75 (s, 2H), 2.32 (s, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1190320-33-2, 6-Fluoro-1H-pyrrolo[3,2-b]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; AKARNA THERAPEUTICS, LTD.; MOHAN, Raju; PRATT, Benjamin, Anthony; (297 pag.)WO2016/103037; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1190320-33-2, name is 6-Fluoro-1H-pyrrolo[3,2-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C7H5FN2

To a solution of 6-Fluoro-lH-pyrrolo[3,2-b]pyridine (CAS: 1190320-33-2 , 6.5 g, 47.74 mmol) in dry DMF (65 mL), was added NaH(3.82 g, 95.49 mmol) at 0C in portions, then the reaction mixture was stirred at room temperature for lh. Methyl iodide (5.30 mL, 95.49 mmol) was added at 0C, then stirred at room temperature for 2h. After the consumption of starting material, reaction mixture was cooled to 0C, added water and extracted with ethyl acetate (2X 100 mL)). The combined organic layers were washed with brine, dried over sodium sulphate and evaporated under reduced pressure to get crude. Crude was purified by column chromatography (230/400 mesh, 30% ethyl acetate in pet-ether) to get desire compound Xllla as white solid (6 g, 85%). LC_MS Calc. for C8H7FN2 150.16; obtained: 151.11H NMR (400 MHz, DMSO-D6): delta 8.33 (s, 1H), 7.89-7.86 (m, 1H), 7.64 (d, 1H, J=2.8 Hz), 6.58 (s, 1H), 3.80 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1190320-33-2, 6-Fluoro-1H-pyrrolo[3,2-b]pyridine.

Reference:
Patent; BUGWORKS RESEARCH INDIA PVT LTD; PEER MOHAMED, Shahul Hameed; BHARATHAM, Nagakumar; KATAGIHALLIMATH, Nainesh; SHARMA, Sreevalli; NANDISHAIAH, Radha; (113 pag.)WO2017/199265; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1190320-33-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1190320-33-2, name is 6-Fluoro-1H-pyrrolo[3,2-b]pyridine, molecular formula is C7H5FN2, molecular weight is 136.13, as common compound, the synthetic route is as follows.

Step 1: 6-Fluoro-lH-pyrrolo[3,2-b]pyridine N-oxide (60) 60 [00667] To a stirred solution of compound 24 (1.2 g, 8.8 mol, 1.0 eq.) in DCM (100 mL), was added mCPBA (2.3 g, 13.2 mmol, 1.5 eq.) at room temperature. After stirring at room temperature overnight, the reaction was cooled at 0 C for lh, and then filtered to collect the solid. The solid was washed with diethyl ether, and then dried under high vacuum give compound 60 (1.3 g, 8.5 mmol, 97%) as a solid, which is used without further purification.

Statistics shows that 1190320-33-2 is playing an increasingly important role. we look forward to future research findings about 6-Fluoro-1H-pyrrolo[3,2-b]pyridine.

Reference:
Patent; AKARNA THERAPEUTICS, LTD.; MOHAN, Raju; PRATT, Benjamin, Anthony; (297 pag.)WO2016/103037; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1190320-33-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1190320-33-2, name is 6-Fluoro-1H-pyrrolo[3,2-b]pyridine, molecular formula is C7H5FN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

step 4: To a solution of 6-fluoro-lH-pyrrolo[3,2-b]pyridine (9.52 g, 70 mmol) in THF (150 mL) at 0 C was added NaH (60%> in mineral oil, 2.02 g, 84 mmol) in three portions. After stirring at RT for 30 min, the mixture was cooled to 0 C and p-TsCl (14.7 g, 77 mmol) was added. The reaction mixture was stirred for 3 h and the temperature was slowly raised to RT. The reaction mixture was poured into ice- cold water and a precipitate was formed. The precipitate was collected by filtration. The crude product was purified by S1O2 chromatography eluting with DCM to afford 18 g (80%) of 6-fluoro-l -tosyl-lH- pyrrolo[3,2-b]pyridine as a solid. MS (ESI): m/z = 291.1 [M+l]+.

According to the analysis of related databases, 1190320-33-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James John; MATHIEU, Simon; RUDOLPH, Joachim; LEE, Wendy; WO2013/92940; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem