Category: 119285-07-3

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 119285-07-3, name is tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate, molecular formula is C14H22N4O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyridine-derivatives

A mixture of 3-chloro-5-[(3R)-3-(3-methyl-2-oxoimidazolidin-l-yl)piperidin-l- yl]pyrazine-2-carbonitrile (322 mg, 1.00 mmol), tert- butyl 4-(5-aminopyridin-2- yl)piperazine-l -carboxylate (293 mg, 1.05 mmol), (acetyloxy)palladio acetate (74 mg, 0.33 mmol), [2′-(diphenylphosphanyl)-[l, T-binaphthalen]-2-yl]diphenylphosphane (206.27 mg, 0.33 mmol) and CS2CO3 (981 mg, 3.01 mmol) was degassed and backfilled with N2 5 times. The mixture was allowed to stir at 100 C for 90 min. The mixture was filtered through Celite washing with MeOH/EtOAc, concentrated and purified by MPLC (0-100% EtOAc in CH2CI2) to afford /er/-butyl 4-[5-({3-cyano-6-[(3R)-3-(3-methyl-2-oxoimidazolidin-l- yl)piperidin- 1 -yl]pyrazin-2-yl } amino)pyridin-2-yl]piperazine- 1 -carboxylate (0.2920 g, 51.7%).

With the rapid development of chemical substances, we look forward to future research findings about 119285-07-3.

Reference:
Patent; NURIX THERAPEUTICS, INC.; ROBBINS, Daniel, W.; SANDS, Arthur, T.; MCINTOSH, Joel; MIHALIC, Jeffrey; WU, Jeffrey; KATO, Daisuke; WEISS, Dahlia; PENG, Ge; (415 pag.)WO2020/81450; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 119285-07-3, Adding some certain compound to certain chemical reactions, such as: 119285-07-3, name is tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate,molecular formula is C14H22N4O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 119285-07-3.

To a solution of 2- (PIPERAZINE-N-T-BUTOXYCARBONYL)-5-AMINO pyridine (70 g, 0.251798 moles) dissolved in acetone (700 ml), sodium bicarbonate (42.3 g, 0.503597 moles) dissolved in water (350 ml), was added and cooled to 0 oC. BENZYLCHLOROFORMATE (85.8 g, 0.503597 moles) was added to the reaction mixture at 0 oC dropwise. After complete addition, the reaction mixture was kept at room temperature for 12 hours. Acetone was removed from the reaction mixture and diluted further with ethylacetate (2L). Washed the ethylacetate layer with water and brine solution. Dried over anhydrous sodium sulphate and concentrated to dryness. The crude compound was crystallized using ethylacetate and hexane to yield the title compound (67.4 g, yield 65 %).

According to the analysis of related databases, 119285-07-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ORCHID CHEMICALS AND PHARMACEUTICALS LTD.; WO2005/3087; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 119285-07-3 ,Some common heterocyclic compound, 119285-07-3, molecular formula is C14H22N4O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(5-Bromo-2-chloro-pyrimidin-4-yl) -cyclopentyl-amine (0.155 g, 0.560 mmol) and 4- (5-amino-pyridin-2-yl)-piperazine-l-carboxylic acid tert-butyl ester (0.156 g9 0.560 mmol) were dissolved in toluene and heated to 115C for 48H. The reaction was cooled and concentrated. Purification on silica gel using 4: 1 HEXANE/ETOAC PROVIDED 0. 130 g (45%) OF 4- [5- (5-BROMO-4-CYCLOPENTYLAMINO- PYRIMIDIN-2-YLAMINO)-PYNIDIN-2-YL]-PIPERAZINE-1-CARBOXYLIC acid tert-butyl ester.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,119285-07-3, its application will become more common.

Reference:
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/65378; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.119285-07-3, name is tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate, molecular formula is C14H22N4O2, molecular weight is 278.3501, as common compound, the synthetic route is as follows.name: tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate

To a stirring solution OF CYCLOPENTYL- (4, 6-DICHLORO- [1, 3,5] triazin-2-yl) – amine (0.60g, 2.57 mmol) prepared as in Example 14A above in 5 ML OF acetonitrile was added 4- (5-AMINO-PYRIDIN-2-YL PIPERAZINE-1-CARBOXYLIC acid tert- butyl ester (0.72g, 2.6 mmol) and triethylamine (0.36 mL, 2.6 mmol). The mixture was stirred at ambient temperature. After 20 minutes, solids formed. The solids were filtered off and washed several times with acetonitrile. The solids were dried in a vacuum oven for 1.5 hours at 60C. Purification was accomplished via silica column chromotography in 7: 1 dichloromethane/acetone. The desired fractions were collected and concentrated in vacuo to afford N- Cyclopentyl-N’, N”-BIS- (6-PIPERAZIN-1-YL-PYRIDIN-3-YL)-1, 3,5-triazine-2, 4,6- triamine (Compound B) as a brown foam/solid (0.234g, 19%). Ms 517.3 ; Mp >290.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,119285-07-3, tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/65378; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 119285-07-3, name is tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate

4-(5-Amino-pyridin-2-yl)-piperazine-l-carboxylic acid tert-butyl ester (1.5 g), 3-Chloro- benzo[l,2,4]triazine 1 -oxide (1.2 g) and DMF (20 ml) and potassium carbonate (1.5 g) were heated to 50-60 C and stirred over night. On completion, water (200 ml) was added and extracted with ethyl acetate (2×200 ml). The combined organic extracts were dried over sodium sulfate. The solvent was removed under reduced pressure to give a residue, which was further purified by column chromatography (SiO2, 25% EtOAc/n-hexane) to yield 4-[5-(l-Oxy- benzo[l,2,4]triazin-3-ylamino)-pyridin-2-yl]-piperazine-l-carboxylic acid tert-butyl ester.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 119285-07-3, tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate.

Reference:
Patent; SENTINEL ONCOLOGY LIMITED; WO2006/131835; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem