Category: 1193-71-1

Adding a certain compound to certain chemical reactions, such as: 1193-71-1, 4,6-Dimethylpyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1193-71-1, blongs to pyridine-derivatives compound. SDS of cas: 1193-71-1

A solution of step 1 intermediate of example 14 (301 mg, 951 pmol) in thionyl chloride (3 mL) was heated to 70 C for 4 h. The volatiles were removed under reduced pressure and the residude was dissolved in CH2CI2 (14 mL) and NEt3 (254 pL, 1.79 mmol) and 4,6-dimethylpyridine-3-amine (114 mg, 940 pmol) were consecutively added and the mixture was stirred at rt overnight. The volatiles were removed underreduced pressure and the residue was purified by chromatography (lnterchim cartridge 5OSiHP /12 g,EtOAc/Cy) to yield the title compound of example 19 (136 mg, 36%).LC-MS (Method 2): m/z [Mi-H] = 421.1 (MW calc. = 420.80); R = 0.59 mm.1H-NMR (DMSO-d6): 6 = 9.84 (s, 1H), 8.36 (s, 1H), 7.93 (s, IH), 7.73 (s, 1H), 7.17 (s, 1H), 6.85 (s, 1H),3.77 (s, 3H), 2.43 (s, 3H), 2.21 (s, 3H) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1193-71-1, its application will become more common.

Reference:
Patent; GRUeNENTHAL GMBH; NORDHOFF, Sonja; VOSS, Felix; WACHTEN, Sebastian; KLESS, Achim; RITTER, Stefanie; WO2015/90580; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1193-71-1, name is 4,6-Dimethylpyridin-3-amine. A new synthetic method of this compound is introduced below., Recommanded Product: 4,6-Dimethylpyridin-3-amine

[0096] A solution of methyl-4-bromobenzoate (1) (430 mg, 2mmol) and 4,6-dimethylpyridin-3-amine (2) (250 mg, 2.1 mmol) in toluene (8 mL) was prepared and the flask was closed. It was purged with nitrogen, then 2M solution of Al(CH3)3 in toluene (1.5 mL) was added drop-wise into the reaction mixture. After the addition was finished, the reaction was microwaved for 15 min at 110C. The reaction mixture was cooled down to room temperature, diluted with EtOAc (20mL), washed with 2N solution of NaOH (2 x lOmL) then brine (1×10 mL). Organic phase was collected and dried over a2S04. Column chromatography afforded 4-bromo-N-(4,6-dimethylpyridin-3-yl)benzamide (A) (yield over 80%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1193-71-1, 4,6-Dimethylpyridin-3-amine.

Reference:
Patent; SYNTA PHARMACEUTICALS CORP.; CHEN, Shoujun; ZHANG, Junyi; JIANG, Jun; KOWALCZYK-PRZEWLOKA, Teresa; XIA, Zhiqiang; ZHANG, Shijie; WO2013/63385; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1193-71-1, 4,6-Dimethylpyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1193-71-1, blongs to pyridine-derivatives compound. SDS of cas: 1193-71-1

A solution of step 1 intermediate of example 14 (301 mg, 951 pmol) in thionyl chloride (3 mL) was heated to 70 C for 4 h. The volatiles were removed under reduced pressure and the residude was dissolved in CH2CI2 (14 mL) and NEt3 (254 pL, 1.79 mmol) and 4,6-dimethylpyridine-3-amine (114 mg, 940 pmol) were consecutively added and the mixture was stirred at rt overnight. The volatiles were removed underreduced pressure and the residue was purified by chromatography (lnterchim cartridge 5OSiHP /12 g,EtOAc/Cy) to yield the title compound of example 19 (136 mg, 36%).LC-MS (Method 2): m/z [Mi-H] = 421.1 (MW calc. = 420.80); R = 0.59 mm.1H-NMR (DMSO-d6): 6 = 9.84 (s, 1H), 8.36 (s, 1H), 7.93 (s, IH), 7.73 (s, 1H), 7.17 (s, 1H), 6.85 (s, 1H),3.77 (s, 3H), 2.43 (s, 3H), 2.21 (s, 3H) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1193-71-1, its application will become more common.

Reference:
Patent; GRUeNENTHAL GMBH; NORDHOFF, Sonja; VOSS, Felix; WACHTEN, Sebastian; KLESS, Achim; RITTER, Stefanie; WO2015/90580; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1193-71-1, name is 4,6-Dimethylpyridin-3-amine. A new synthetic method of this compound is introduced below., Recommanded Product: 4,6-Dimethylpyridin-3-amine

[0096] A solution of methyl-4-bromobenzoate (1) (430 mg, 2mmol) and 4,6-dimethylpyridin-3-amine (2) (250 mg, 2.1 mmol) in toluene (8 mL) was prepared and the flask was closed. It was purged with nitrogen, then 2M solution of Al(CH3)3 in toluene (1.5 mL) was added drop-wise into the reaction mixture. After the addition was finished, the reaction was microwaved for 15 min at 110C. The reaction mixture was cooled down to room temperature, diluted with EtOAc (20mL), washed with 2N solution of NaOH (2 x lOmL) then brine (1×10 mL). Organic phase was collected and dried over a2S04. Column chromatography afforded 4-bromo-N-(4,6-dimethylpyridin-3-yl)benzamide (A) (yield over 80%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1193-71-1, 4,6-Dimethylpyridin-3-amine.

Reference:
Patent; SYNTA PHARMACEUTICALS CORP.; CHEN, Shoujun; ZHANG, Junyi; JIANG, Jun; KOWALCZYK-PRZEWLOKA, Teresa; XIA, Zhiqiang; ZHANG, Shijie; WO2013/63385; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1193-71-1, name is 4,6-Dimethylpyridin-3-amine, molecular formula is C7H10N2, molecular weight is 122.17, as common compound, the synthetic route is as follows.Formula: C7H10N2

4-{[(3,5-dimethyl-4-isoxazolyl)methyl]oxy}benzenesulfonyl chloride (247 mg, 0.819 mmol) was added to a solution of triethylamine (0.114 mL, 0.819 mmol) and 4,6-dimethyl-3-pyridinamine (100 mg, 0.819 mmol) in dichloromethane (1 mL). The mixture was heated at 70 C. for 2 hours. To the mixture was added water (5 mL) then the organic layer separated and purified by silica (Si) chromatography (100% ethyl acetate). The relevant fractions were combined and concentrated to give the title product (310 mg) as a yellow solid. LCMS (2 min, formic) Rt 0.63 mins, m/z (ES+) 388 (M+H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1193-71-1, 4,6-Dimethylpyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; Glaxo Group Limited; Birault, Veronique; Campbell, Amanda Jennifer; Harrison, Stephen; Le, Joelle; Shukla, Lena; US2015/65507; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1193-71-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1193-71-1, name is 4,6-Dimethylpyridin-3-amine. A new synthetic method of this compound is introduced below.

33: 1-(4-Methoxy-phenyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (4,6-dimethyl-pyridin-3-yl)-amideTo a suspension of 1-(4-methoxy-phenyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid IM51 (1.60 g, 5.38 mmol), 5-amino-2,4-dimethylpyridine (786 mg, 6.43 mmol) and triethylamine (3.00 mL, 21.5 mmol) in THF (20 mL) was added a 50% (w/w) solution of 1-propanephosphonic acid cyclic anhydride in THF (6.84 g, 10.7 mmol) drop wise over 10 min. The mixture was stirred at room temperature Overnight. The mixture was poured into water (20 mL). The THF was removed in vacuo. Aqueous NH3 solution was added to adjust pH to approximately 10 EtOH (25 mL) was added and the mixture was briefly heated to reflux and then left at room temperature overnight. The mixture was then cooled on an ice-water bath for 45 min and then filtered. The remanens was washed with water and dried in vacuo to give the title compound (1.41 g, 67%). 1H NMR (600 MHz, DMSO) delta 10.43 (s, 1H), 8.47 (s, 1H), 8.09-8.04 (m, 2H), 7.46 (s, 1H), 7.23 (s, 1H), 7.16-7.11 (m, 2H), 3.83 (s, 3H), 2.71 (s, 3H), 2.57 (s, 3H), 2.46 (s, 3H), 2.29 (s, 3H).LC-MS (m/z) 402.2 (MH+); tR=0.52.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1193-71-1, 4,6-Dimethylpyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; H. Lundbeck A/S; US2013/5743; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1193-71-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1193-71-1 as follows.

[00112] To the solution of 4-(5-ethyl-2-(5-methylpyrazin-2-yl)thiazol-4-yl)benzoate (75 mg, 0.22 mmol) in toluene (4 mL) was added 4,6-dimethylpyridin-3-amine (53 mg, 0.42 mmol) and AlMe3 (2M solution in toluene, 0.21 mL, 0.42 mmol). The reaction was heated in microwave at 110 C for 15 min before it was diluted with EtOAc (15 mL) and washed with IN NaOH (25 mL chi 2). The organic phase was dried over magnesium sulfate, filtered, and concentrated. Column chromatography gave compound 5 in 81% yield. [00113] NMR (400 MHz, CDCls) delta 9.34 (d, / = 1.5 Hz, 1H), 8.75 (s, 1H), 8.43 (d, / = 1.5 Hz, 1H), 8.04 – 7.99 (m, 2H), 7.89 – 7.83 (m, 2H), 7.73 (s, 1H), 7.08 (s, 1H), 3.08 (q, / = 7.5 Hz, 2H), 2.64 (s, 3H), 2.54 (s, 3H), 2.32 (s, 3H), 1.43 (t, / = 7.4 Hz, 3H). ESMS cacld (C24H23N5OS): 429.2; found: 430.3 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1193-71-1, its application will become more common.

Reference:
Patent; SYNTA PHARMACEUTICALS CORP.; CHEN, Shoujun; ZHANG, Junyi; JIANG, Jun; KOWALCZYK-PRZEWLOKA, Teresa; XIA, Zhiqiang; ZHANG, Shijie; WO2013/63385; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1193-71-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1193-71-1, name is 4,6-Dimethylpyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows.

Intermediate 73: 4-{F(3,5-d imethyl-4-isoxazolyi)methyl]oxy}-N-(4,6-dimethyl-3-Ivridinvi)benzenesulfonamide4-{[(3,5-d imethyl-4-isoxazolyl)methyl]oxy}benzenesulfonyl chloride (247 mg, 0.819 mmol) was added to a solution of triethylamine (0.114 mL, 0.819 mmol) and 4,6-dimethyl-3-pyridinamine (100 mg, 0.819 mmol) in dichloromethane (1 mL). The mixture was heated at 70 0C for 2 hours. To themixture was added water (5 mL) then the organic layer separated and purified by silica (Si) chromatography (100 % ethyl acetate). The relevant fractions were combined and concentrated togive the title product (310 mg) as a yellow solid. LCMS (2 mm, formic) Rt 0.63 mins, m/z (ESj 388 (M+H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1193-71-1, 4,6-Dimethylpyridin-3-amine.

Reference:
Patent; GLAXO GROUP LIMITED; BIRAULT, Veronique; CAMPBELL, Amanda, Jennifer; HARRISON, Stephen; LE, Joelle; SHUKLA, Lena; WO2013/160419; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem