Adding a certain compound to certain chemical reactions, such as: 119396-04-2, 4-Chloro-2-(chloromethyl)pyridine hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 119396-04-2, blongs to pyridine-derivatives compound. Computed Properties of C6H6Cl3N
4-chloro-2-(chloromethyl)pyridine hydrochloride (200 mg, 1.02 mmol) was dissolved in chloroform (15 mL) and cooled in water/ice bath m-chloroperoxobenzoic acid (77%, 350mg, 1.56 mmol) was added and the reaction mixture was stirred for 24 hours while letting towarm up to room temperature. The solvent was evaporated on rotary evaporator and theresidue was purified by flash chromatography on silica in 5% methanol / 95 %dichloromethane mixture, giving 143 mg of the product as white solid (0.803 mmol, 79 % yield).500 MHz): 4.90 (C H2, s, 2H); 7.26 ( arom ., dd, 1H,3/HH= 7 Hz,4/HH = 3 Hz); 7.64 (arom., d, 1H,4/HH= 3 Hz); 8.20 (arom., d, 1H,3/HH= 7 Hz);13C{ NMR (CDCl3, 25 C, 125 MHz): 5c 39.6 (CH2, s); 125.6 (arom., s); 125.9 (arom., s); 132.4 (arom., s); 140.2 (arom., s); 148.7 (arom., s).HRMS (ESI) m/z: [(M + H)+] (C6H6Cl2NO) calculated: 177.9821, found: 177.9820.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,119396-04-2, its application will become more common.
Reference:
Patent; USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I.; POLASEK, Miloslav; (102 pag.)WO2019/106182; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem