Category: 1196157-51-3

9/26 News Extracurricular laboratory: Synthetic route of 1196157-51-3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1196157-51-3, 2-Amino-6-bromonicotinic acid, other downstream synthetic routes, hurry up and to see.

Application of 1196157-51-3 ,Some common heterocyclic compound, 1196157-51-3, molecular formula is C6H5BrN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

N-Chlorosuccinimide (2.78 g, 20.8 mmol) was added to a solution of 2-amino-6-bromonicotinic acid (4.51 g, 20.8 mmol, Ark Pharm Inc. Arlington Heights, IL, USA) in DMF (75 mL), and the resulting mixture was heated at 70 C for 2.5 h. Heating was then stopped, and stirring was continued for 16 h. The reaction mixture was subsequently poured into ice water. After the ice had melted, the resulting slurry was filtered through a fritted glass funnel. The collected solids were air- dried, providing 2-amino-6-bromo-5-chloronicotinic acid: ?H NMR (400 MHz, DMSO-d6) oe 8.05 (s, 1H), 7.64 (br. s, 2H). m/z (ESI, +ve) 250.9 (M+H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1196157-51-3, 2-Amino-6-bromonicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AMGEN INC.; LANMAN, Brian Alan; CEE, Victor J.; PICKRELL, Alexander J.; REED, Anthony B.; YANG, Kevin C.; KOPECKY, David John; WANG, Hui-Ling; LOPEZ, Patricia; ASHTON, Kate; BOOKER, Shon; TEGLEY, Christopher M.; (303 pag.)WO2018/119183; (2018); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

9/26 News Extracurricular laboratory: Synthetic route of 1196157-51-3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1196157-51-3, 2-Amino-6-bromonicotinic acid, other downstream synthetic routes, hurry up and to see.

Application of 1196157-51-3 ,Some common heterocyclic compound, 1196157-51-3, molecular formula is C6H5BrN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

N-Chlorosuccinimide (2.78 g, 20.8 mmol) was added to a solution of 2-amino-6-bromonicotinic acid (4.51 g, 20.8 mmol, Ark Pharm Inc. Arlington Heights, IL, USA) in DMF (75 mL), and the resulting mixture was heated at 70 C for 2.5 h. Heating was then stopped, and stirring was continued for 16 h. The reaction mixture was subsequently poured into ice water. After the ice had melted, the resulting slurry was filtered through a fritted glass funnel. The collected solids were air- dried, providing 2-amino-6-bromo-5-chloronicotinic acid: ?H NMR (400 MHz, DMSO-d6) oe 8.05 (s, 1H), 7.64 (br. s, 2H). m/z (ESI, +ve) 250.9 (M+H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1196157-51-3, 2-Amino-6-bromonicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AMGEN INC.; LANMAN, Brian Alan; CEE, Victor J.; PICKRELL, Alexander J.; REED, Anthony B.; YANG, Kevin C.; KOPECKY, David John; WANG, Hui-Ling; LOPEZ, Patricia; ASHTON, Kate; BOOKER, Shon; TEGLEY, Christopher M.; (303 pag.)WO2018/119183; (2018); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New learning discoveries about 2-Amino-6-bromonicotinic acid

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1196157-51-3, 2-Amino-6-bromonicotinic acid, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 1196157-51-3, Adding some certain compound to certain chemical reactions, such as: 1196157-51-3, name is 2-Amino-6-bromonicotinic acid,molecular formula is C6H5BrN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1196157-51-3.

Step 1: 2-Amino-6-bromo-5-chloronicotinic acid N-Chlorosuccinimide (2.78 g, 20.8 mmol) was added to a solution of 2-amino-6-bromonicotinic acid (4.51 g, 20.8 mmol, Ark Pharm Inc. Arlington Heights, Ill., USA) in DMF (75 mL), and the resulting mixture was heated at 70 C. for 2.5 h. Heating was then stopped, and stirring was continued for 16 h. The reaction mixture was subsequently poured into ice water. After the ice had melted, the resulting slurry was filtered through a fritted glass funnel. The collected solids were air-dried, providing 2-amino-6-bromo-5-chloronicotinic acid: 1H NMR (400 MHz, DMSO-d6) delta 8.05 (s, 1H), 7.64 (br. s, 2H). m/z (ESI, +ve) 250.9 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1196157-51-3, 2-Amino-6-bromonicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Amgen Inc.; LANMAN, Brian Alan; CHEN, Jian; REED, Anthony B.; CEE, Victor J.; LIU, Longbin; KOPECKY, David John; LOPEZ, Patricia; WURZ, Ryan Paul; NGUYEN, Thomas T.; BOOKER, Shon; NISHIMURA, Nobuko; SHIN, Youngsook; TAMAYO, Nuria A.; ALLEN, John Gordon; ALLEN, Jennifer Rebecca; (266 pag.)US2018/334454; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem