Category: 1198103-43-3

The origin of a common compound about 1198103-43-3

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1198103-43-3, (6-(Difluoromethoxy)pyridin-3-yl)methanamine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1198103-43-3, (6-(Difluoromethoxy)pyridin-3-yl)methanamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H8F2N2O, blongs to pyridine-derivatives compound. HPLC of Formula: C7H8F2N2O

Phenyl formate (0.17 mL, 1.5 mmol) was added to a solution of (6- (difluoromethoxy)pyridin-3-yl)methylamine (0.261 g, 1.50 mmol) in dry dichloromethane (5 mL). The mixture was stirred at room temperature for 18 hours then the volatiles were removed in vacuo. The crude residue was purified by silica gel column chromatography using dichloromethane : methanol = 100:0 to 95:5 as gradient affording the title compound as white solid, 250 mg (82 %). 1H NMR (400 MHz, CDCl3) delta (ppm) 8.29 (s, 1 H) 8.12 (s, 1 H) 7.72 (d, 1 H) 7.45 (t, 1 H) 6.89 (d, 1 H) 5.81 (m, 1 H) 4.48 (d, 2 H). 19F NMR (400 MHz, CDCl3) delta (ppm) -89.30 and -89.49. MS (ESI) m/z 202 [M+H].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1198103-43-3, (6-(Difluoromethoxy)pyridin-3-yl)methanamine, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; WO2009/145720; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem