1206968-88-8 | Pyridine-derivatives

Sources of common compounds: (5-Bromo-3-chloropyridin-2-yl)methanol

The synthetic route of 1206968-88-8 has been constantly updated, and we look forward to future research findings.

Reference of 1206968-88-8 , The common heterocyclic compound, 1206968-88-8, name is (5-Bromo-3-chloropyridin-2-yl)methanol, molecular formula is C6H5BrClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[01340] A mixture of (5-bromo-3-chloropyridin-2-yl)methanol (2 g, 8.99 mmol, 1.00 equiv), Mn02 (7.77 g, 89.34 mmol, 9.94 equiv), and dichloromethane (150 mL) was stirred for overnight at 40C. The solids were filtrated out and the filtrate was concentrated. The residue was purified by a silica gel colunm eluting with ethyl acetate/petroleum ether (1/20) to afford the title compound (1.1 g, 56%) as a light yellow solid. LCMS [M+H] 222.

The synthetic route of 1206968-88-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ESTRADA, Anthony; VOLGRAF, Matthew; CHEN, Huifen; KOLESNIKOV, Aleksandr; VILLEMURE, Elisia; VERMA, Vishal; WANG, Lan; SHORE, Daniel; DO, Steven; YUEN, Po-wai; HU, Baihua; WU, Guosheng; LIN, Xingyu; LU, Aijun; (537 pag.)WO2016/128529; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of (5-Bromo-3-chloropyridin-2-yl)methanol

With the rapid development of chemical substances, we look forward to future research findings about 1206968-88-8.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1206968-88-8, name is (5-Bromo-3-chloropyridin-2-yl)methanol, molecular formula is C6H5BrClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C6H5BrClNO

With the rapid development of chemical substances, we look forward to future research findings about 1206968-88-8.

Extracurricular laboratory: Synthetic route of 1206968-88-8

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1206968-88-8, (5-Bromo-3-chloropyridin-2-yl)methanol, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1206968-88-8, (5-Bromo-3-chloropyridin-2-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of (5-Bromo-3-chloropyridin-2-yl)methanol, blongs to pyridine-derivatives compound. Quality Control of (5-Bromo-3-chloropyridin-2-yl)methanol

DMP (45.83g, 102.lOmmoI) was added portion wise to a stirred solution of (5-bromo-3-chloropyridin-2-yl)-methanol (16g, 72.O7mmoI) in DCM (320mL) at 0C and stirred for 16h at RT. The RM was filtered through celite and washed with DCM (3x100mL).The filtrate was washed with Aq.NaHCO3 (200mL), water (200mL), brine(250mL), dried (Na2SO4), filtered, concentrated under reduced pressure to give crude. The crude was purified by CC (0-5% EtOAc in PE) to give 5-bromo-3-chloropicolinaldehyde (lOg, 66%) as light yellow solid.

Reference:
Patent; GRUeNENTHAL GMBH; SCHUNK, Stefan; REICH, Melanie; JAKOB, Florian; DAMANN, Nils; HAURAND, Michael; KLESS, Achim; ROGERS, Marc; SUTTON, Kathy; WO2015/158427; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Share a compound : 1206968-88-8

The chemical industry reduces the impact on the environment during synthesis 1206968-88-8, I believe this compound will play a more active role in future production and life.

Electric Literature of 1206968-88-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1206968-88-8, name is (5-Bromo-3-chloropyridin-2-yl)methanol, molecular formula is C6H5BrClNO, molecular weight is 222.467, as common compound, the synthetic route is as follows.

The chemical industry reduces the impact on the environment during synthesis 1206968-88-8, I believe this compound will play a more active role in future production and life.

Extracurricular laboratory: Synthetic route of 1206968-88-8

Adding a certain compound to certain chemical reactions, such as: 1206968-88-8, (5-Bromo-3-chloropyridin-2-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives