Category: 1206979-33-0

Adding a certain compound to certain chemical reactions, such as: 1206979-33-0, 6-Chloro-1H-pyrazolo[4,3-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1206979-33-0, blongs to pyridine-derivatives compound. category: pyridine-derivatives

At r.t. to a suspension of 6-chloro-1H-pyrazolo[4,3-c]pyridine (0.5 g, 3 mmol) (Frontier Cat. No. Z13659) in methylene chloride (3 mL) and THF (1 mL) was added methanesulfonic acid (42 muL, 0.65 mmol), followed by dihydropyran (0.89 mL, 9.8 mmol). The mixture was stirred at r.t. for 2 h., and then at 50 C. overnight. After cooling the mixture was concentrated under reduced pressure. The residue was purified by flash chromatography on a silica gel column with ethyl acetate in hexanes (0-50%) to afford the desired product (0.8 g). LCMS (M+H)+=238.0; LCMS (M-84+H)+=154.0/156.0.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1206979-33-0, its application will become more common.

Reference:
Patent; Incyte Corporation; Zhuo, Jincong; Xu, Meizhong; Qian, Ding-Quan; US2014/171405; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1206979-33-0, 6-Chloro-1H-pyrazolo[4,3-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1206979-33-0, blongs to pyridine-derivatives compound. Product Details of 1206979-33-0

To a mixture of tert-butyl 4-(6-bromopyridin-2-yl)-6-methoxy-6-methyl-1,4-diazepane-1-carboxylate (530 mg, 1.33 mmol) and 6-chloro-1H-pyrazolo[4,3-c]pyridine (203 mg, 1.33mmol) in 1,4-dioxane (30 mL) was added Cul (101 mg, 0.53 mmol), N1,N2-dimethylethane-1,2-diamine (94 mg, 1.06 mmol), and K2CO3 (734 mg, 5.32 mmol). The mixture was heated at 100C, which was monitored by LCMS. After completion of the reaction, it was concentrated under reduced pressure. The crude material was purified by silica gel chromatography using petroleumether:EtOAc (3:1~1:1) as eluting solvents to afford tert-butyl 4-(6-(6-chloro-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)-6-methoxy-6-methyl-1,4-diazepane-1-carboxylate as yellow solid. (446 mg, 71%). MS (ESI) m/z: 473 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1206979-33-0, 6-Chloro-1H-pyrazolo[4,3-c]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; DO, Steven; HU, Huiyong; KOLESNIKOV, Aleksandr; TSUI, Vickie, H.; WANG, Xiaojing; WO2014/1377; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1206979-33-0, Adding a certain compound to certain chemical reactions, such as: 1206979-33-0, 6-Chloro-1H-pyrazolo[4,3-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1206979-33-0, blongs to pyridine-derivatives compound.

A suspension of 6-chloro-lH-pyrazolo[4,3-c]pyridine (lg, 6.54mmol), l-(bromomethyl)-2- fluorobenzene (l . leq) and potassium carbonate (2eq) in acetonitrile (20mL) was heated at 60C for 18h. The resultant mixture was diluted with DCM and washed with H20. The organic phase was collected, dried (hydrophobic frit) and concentrated in vacuo. The resultant residue was purified by column chromatography (DCM:EtOAc) to give 6-chloro-l- (2-fluorobenzyl)-lH-pyrazolo[4,3-c]pyridine.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1206979-33-0, its application will become more common.

Reference:
Patent; CELLZOME LIMITED; OXENFORD, Sally; HOBSON, Andrew; OLIVER, Kathryn; RATCLIFFE, Andrew; RAMSDEN, Nigel; WO2013/17479; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem