Category: 1206980-39-3

Manteau, Baptiste published the artcileA General Approach to (Trifluoromethoxy)pyridines: first X-ray Structure Determinations and Quantum Chemistry Studies, Recommanded Product: 2-Chloro-3-(trifluoromethoxy)pyridine, the main research area is general approach synthesis Trifluoromethoxy pyridines crystal structure; ab initio energy profiles rotation trifluoromethoxy methoxy pyridines.

The previously unknown 2-, 3-, and 4-(trifluoromethoxy)pyridines have now become readily accessible by means of an efficient and straightforward large-scale synthesis. Their regioselective functionalization by organometallic methods has been studied and has afforded new and highly important building blocks for life-sciences-oriented research. In addition, the first X-ray crystallog. structure determinations of (trifluoromethoxy)pyridines have been performed. Lowest-energy conformations of (trifluoromethoxy)pyridines and (trifluoromethoxy)pyridinium cations were determined by in silico studies.

European Journal of Organic Chemistry published new progress about Anomeric effect. 1206980-39-3 belongs to class pyridine-derivatives, name is 2-Chloro-3-(trifluoromethoxy)pyridine, and the molecular formula is C6H3ClF3NO, Recommanded Product: 2-Chloro-3-(trifluoromethoxy)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Yu-Ming published the artcileSilver-Mediated Trifluoromethoxylation of (Hetero)aryldiazonium Tetrafluoroborates, Name: 2-Chloro-3-(trifluoromethoxy)pyridine, the main research area is silver mediated Sandmeyer fluoromethoxylation aryl heteroaryl amine.

Here we report a silver-mediated trifluoromethoxylation of (hetero)aryldiazonium tetrafluoroborates by converting an aromatic amino group into an OCF3 group. This method, which can be considered to be a trifluoromethoxylation variation of the classic Sandmeyer-type reaction, uses readily available aryl and heteroaromatic amines as starting materials and AgOCF3 as trifluoromethoxylating reagents. The broad substrate scope and simple, mild reaction condition made this transformation a valuable method in constructing aryl-OCF3 bonds.

Organic Letters published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1206980-39-3 belongs to class pyridine-derivatives, name is 2-Chloro-3-(trifluoromethoxy)pyridine, and the molecular formula is C6H3ClF3NO, Name: 2-Chloro-3-(trifluoromethoxy)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1206980-39-3, name is 2-Chloro-3-(trifluoromethoxy)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Chloro-3-(trifluoromethoxy)pyridine

2-Bromo-3-trifluoromethoxypyridine (23); A solution of 2-chloro-3-trifluoromethoxypyridine (8, 4.0 g, 20.2 mmol) and bromotrimethylsilane (6.3 g, 5.4 mL, 40.4 mmol, 2 eq) in propionitrile (20 mL) was heated under reflux for 24 h. GC monitoring indicated 100% conversion. The mixture was distilled in vacuum to afford pure 2-bromo-3-trifluoromethoxypyridine (23, 3.9 g, 16.1 mmol, 80%) as a colorless oil; b.p. 63-67 0C / 13 mbar.1H NMR (CDCl3, 300 MHz): delta = 8.38 (dd, J = 4.7, 1.6 Hz, 1 H), 7.68 (d, J = 8.1, 1.6Hz, 1 H), 7.34 (dd, J = 8.1, 4.7 Hz, 1 H). – 19F NMR (CDCl3, 282 MHz): delta = -58.0. – 13C NMR (CDCl3, 75 MHz): delta = 147.8, 144.8, 142.2, 130.5, 123.7, 120.3 (q, J = 260 Hz). – C6H3ClF3NO (241): calcd. (%) C 29.78, H 1.25, N 5.79; found C 29.96, H 1.41, N 5.64.

With the rapid development of chemical substances, we look forward to future research findings about 1206980-39-3.

Reference:
Patent; BAYER CROPSCIENCE AG; PAZENOK, Sergii; VORS, Jean-Pierre; LEROUX, Frederic, R.; MANTEAU, Baptiste; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE DE STRASBOURG; WO2010/40461; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1206980-39-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1206980-39-3 as follows.

4-Amino-2-chloro-3-trifluoromethoxy pyridine (20); At 0 0C, diisopropylamine (1.2 g, 1.6 mL, 11.1 mmol, 1.1 eq) was added dropwise to a solution of butyllithium (1.56 M in hexane, 7.1 mL, 11.1 mmol, 1.1 eq) in THF (15 mL). At -78 0C, a solution of 2-chloro-3-trifluoromethoxy pyridine (8, 2.0 g, 10.1 mmol, 1 eq) in THF (5 mL) was added dropwise followed after 2 h by benzenesulfonyl azide (2.8 g, 15.2 mmol, 1.5 eq). The reaction mixture was allowed to reach 25 0C before being treated with a saturated aqueous solution of ammonium chloride (20 mL) and extracted with diethylehter (3 x 10 mL). The combined organic layers were dried over sodium sulfate and evaporated to afford a crude red oil of 4-azido-2-chloro-3- trifluoromethoxypyridine. It was then dissolved in anhydrous diethylether (90 mL) and added dropwise to a suspension of lithium aluminium hydride (430 mg, 11.2 mmol, 1.1 eq) in diehtylether (90 mL). The reaction mixture was heated under reflux for 5 h before being treated with water (100 mL) and extracted with diethylether (3 x 30 mL). The combined organic layers were dried over sodium sulfate before being evaporated. The crude product was purified by chromatography on silica gel using ethyl acetate/cyclohexane (1 :4) as eluent which afforded pure 4-amino-2-chloro-3- trifluoromethoxy pyridine (20, 1.6 g, 7.5 mmol, 75%) as yellow crystals; m.p. 54-56 0C.1H NMR (CDCl3, 300 MHz): delta = 7.78 (d, J = 5.5 Hz, 1 H), 6.51 (d, J = 5.5 Hz, 1 H), 4.69 (bs, 2 H). – 19F NMR (CDCl3, 282 MHz): delta = -57.0. – 13C NMR (CDCl3, 75 MHz): delta = 171.2, 148.4, 147.0, 146.3, 120.9 (q, J= 260 Hz), 111.0. – HRMS (ESI positive) forC6H5ClF3N2O [M+H]: calcd. 213.0037; found 213.0051. – C7H3ClF3NO3 (212): calcd. (%) C 33.90, H 1.90, N 13.18; found C 33.45, H 2.10, N 13.40.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1206980-39-3, its application will become more common.

Reference:
Patent; BAYER CROPSCIENCE AG; PAZENOK, Sergii; VORS, Jean-Pierre; LEROUX, Frederic, R.; MANTEAU, Baptiste; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE DE STRASBOURG; WO2010/40461; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem