Category: 120739-77-7

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 120739-77-7, name is N-((6-Chloropyridin-3-yl)methyl)ethanamine. A new synthetic method of this compound is introduced below., name: N-((6-Chloropyridin-3-yl)methyl)ethanamine

Synthesis Example 3 2-chloro-5-[N-trifluoroacetyl-N-ethyl]aminomethylpyridine (Compound 21) A solution of 140 mg (0.67 mmol) of trifluoroacetic anhydride dissolved in 5 mL of anhydrous dichloromethane was added dropwise under ice cooling to a solution of 120 mg (0.70 mmol) of ethyl-(2-chloro-5-pyridylmethyl)amine synthesized by the method described in U.S. Patent Application Publication No. 2009306041 and 101 mg (1 mmol) of triethylamine dissolved in 5 mL of anhydrous dichloromethane. Following dropwise addition, the system was stirred overnight at room temperature, then the reaction mixture was washed with, in order, ice-cooled 1% aqueous sodium hydroxide, water, 1% hydrochloric acid, then water, and subsequently dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, giving 107 mg the target compound (yield, 78%).

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Reference:
Patent; MEIJI SEIKA PHARMA CO., LTD.; KAGABU, Shinzo; MITOMI, Masaaki; KITSUDA, Shigeki; HORIKOSHI, Ryo; NOMURA, Masahiro; ONOZAKI, Yasumichi; US2013/150414; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 120739-77-7, name is N-((6-Chloropyridin-3-yl)methyl)ethanamine. A new synthetic method of this compound is introduced below., name: N-((6-Chloropyridin-3-yl)methyl)ethanamine

Synthesis Example 3 2-chloro-5-[N-trifluoroacetyl-N-ethyl]aminomethylpyridine (Compound 21) A solution of 140 mg (0.67 mmol) of trifluoroacetic anhydride dissolved in 5 mL of anhydrous dichloromethane was added dropwise under ice cooling to a solution of 120 mg (0.70 mmol) of ethyl-(2-chloro-5-pyridylmethyl)amine synthesized by the method described in U.S. Patent Application Publication No. 2009306041 and 101 mg (1 mmol) of triethylamine dissolved in 5 mL of anhydrous dichloromethane. Following dropwise addition, the system was stirred overnight at room temperature, then the reaction mixture was washed with, in order, ice-cooled 1% aqueous sodium hydroxide, water, 1% hydrochloric acid, then water, and subsequently dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, giving 107 mg the target compound (yield, 78%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 120739-77-7, N-((6-Chloropyridin-3-yl)methyl)ethanamine.

Reference:
Patent; MEIJI SEIKA PHARMA CO., LTD.; KAGABU, Shinzo; MITOMI, Masaaki; KITSUDA, Shigeki; HORIKOSHI, Ryo; NOMURA, Masahiro; ONOZAKI, Yasumichi; US2013/150414; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 120739-77-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.120739-77-7, name is N-((6-Chloropyridin-3-yl)methyl)ethanamine, molecular formula is C8H11ClN2, molecular weight is 170.6393, as common compound, the synthetic route is as follows.

Example 3Synthesis of (1E)-N-[(6-chloro-3-pyridinyl)methyl]-N-ethyl-N’-methyl-2-nitro-1,1-ethenediamine (third batch)351.9 g of n-butyl acetate and 102.7 g of a 35% potassium carbonate aqueous solution were charged in a 1-L separable flask. The solution was cooled to -4 C., 48.8 g of 1,1-dichloro-2-nitroethene (net weight 40.6 g) was added dropwise while stirring over 30 minutes, and 44.8 g of 2-chloro-5-(ethylaminomethyl)pyridine (net weight 44.4 g) was subsequently added dropwise over 3 hours. The reaction mixture was stirred at -4 C. for 15 minutes, 60.6 g of a 40% methyl amine aqueous solution was added dropwise over 3 hours, and stirring was further continued for 4 hours.The obtained reaction mixture was warmed to 15 C. and extracted four times with the extracted aqueous layers 1, 2 and 3 obtained in Example 2 (50.3 g, 45.2 g, and 31.9 g, respectively) and 30.0 g of water, and the obtained four extracted aqueous layers were combined. The combined aqueous layer obtained was extracted at 15 C. four times with the extracted 5-ethyl-2-methylpyridine layers 1, 2 and 3 obtained in Example 2 (85.5 g, 85.6 g and 90.4 g, respectively) and 75.0 g of 5-ethyl-2-methylpyridine, and the obtained four extracted 5-ethyl-2-methylpyridine layers were combined. After washing the combined 5-ethyl-2-methylpyridine layer with 50.0 g of saturated sodium sulfate solution, 800 g of n-heptane was added thereto and the mixture was concentrated at 4.5 kPa, 25 to 35 C. until the amount of the residual solution was 350.6 g. 20.0 g of 5-ethyl-2-methylpyridine was added to the concentrated mass, and the mixture was maintained at 40 C. for 1 hour followed by filtration to remove insoluble matters.The obtained filtrate was flushed down with 10.0 g of 5-ethyl-2-methylpyridine to a 500 ml separable flask, the temperature was adjusted to 35 C., and then 20.0 g of n-heptane was added dropwise over minutes. 0.01 g of seed crystals of (1E)-N-[(6-chloro-3-pyridinyl)methyl]-N-ethyl-N’-methyl-2-nitro-1,1-ethenediamine was added to the mass and the mixture was cooled to 15 C. over 5 hours, and subsequently cooled to -10 C. over 10 hours for crystallization. The crystalline mass was further stirred at -10 C. for 3 hours and filtered. The obtained crystals were washed with 60.0 g of 5-ethyl-2-methylpyridine/n-heptane (9/1 weight ratio) which had been cooled to -10 C., and subsequently washed with 200.0 g of n-heptane cooled to -10 C. The washed crystals were dried at 2.7 kPa, 40 C. for 4 hours to obtain 61.4 g of (1E)-N-[(6-chloro-3-pyridinyl)methyl]-N-ethyl-N’-methyl-2-nitro-1,1-ethenediamine with a content of 99.2%.

Statistics shows that 120739-77-7 is playing an increasingly important role. we look forward to future research findings about N-((6-Chloropyridin-3-yl)methyl)ethanamine.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; US2011/184184; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 120739-77-7 ,Some common heterocyclic compound, 120739-77-7, molecular formula is C8H11ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(2) 20.16 g of the above crude product were dissolved in 114 ml of chloroform and to the resulting solution was added a solution of 26.34 g (0.2486 mol) of sodium carbonate in 114 ml of water at 2-7 C. with stirring. Then, 13.5 g (0.0791 mol) of N-(6-chloro-3-pyridyl)methyl-N-ethylamine were dropwise added to the mixture at 5-6 C. and stirred for 40 minutes. Further, 31.59 g (0.407 mol) of 40% methylamine were dropwise added to the mixture at 3-7 C., followed by stirring for 30 minutes under ice-cooling and 30 minutes at room temperature. The separated aqueous layer was extracted with 48 ml of chloroform. The combined chloroform layers were concentrated, and the residue to which 39 ml of ethyl acetate were added was ice-cooled to precipitate pale yellowish crystals of 1-[N-(6-chloro-3-pyridyl)methyl-N-ethyl]amino-1-methylamino-2-nitroethylene. Yield: 18.15 g (84.9%). mp. 83-84 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 120739-77-7, N-((6-Chloropyridin-3-yl)methyl)ethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US5364989; (1994); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 120739-77-7, name is N-((6-Chloropyridin-3-yl)methyl)ethanamine, the common compound, a new synthetic route is introduced below. Application In Synthesis of N-((6-Chloropyridin-3-yl)methyl)ethanamine

To prepare compound 4e a solution of 4d (1 mmol) and N-((6-chloropyridin-3-yl)methyl)ethanamine (0.187 g, 1.1 mmol) in acetonitrile (4 mL) was heated under reflux. The progress of the reaction was monitored by TLC. After completion, the cooled mixture was filtered and the precipitate was washed with cold acetonitrile (4 mL) to afford the desired product 4e.

The synthetic route of 120739-77-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Nanyang; Xia, Shanshan; Zou, Minming; Shao, Xusheng; Research on Chemical Intermediates; vol. 41; 8; (2015); p. 5293 – 5300;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 120739-77-7 ,Some common heterocyclic compound, 120739-77-7, molecular formula is C8H11ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a 100 mL three neck round bottom flask, 17.0 g (0.1 mol) of N-(6-chloropyridine-3-methylene)ethylamine, 15.0 g (0.09 mol) of 1,1-dimethylthio-2-nitroethylene, and 50 mL of absolute ethanol were added. Heated to reflux. Reflux for 8h. Stop reflow, cooled to room temperature. Concentrated to viscous liquid. Silica gel column chromatography (dichloromethane: acetone = 5: 1 (v / v)) gave the product 6.5 g (compound IV-1) in a yield of 23%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,120739-77-7, its application will become more common.

Reference:
Patent; East China University of Science and Technology; Li, Zhong; Xu, Xiaoyong; Yuan, Zihao; Lu, Siyuan; Shao, Xusheng; Xu, Zhiping; (66 pag.)CN105669660; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem