Synthetic Route of 120739-87-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.120739-87-9, name is 4-(Chloromethyl)-2,6-dimethylpyridine, molecular formula is C8H10ClN, molecular weight is 155.6247, as common compound, the synthetic route is as follows.
b) 4-(2,6-Dimethylpyridyl)acetonitrile; To 4 mL of DMSO solution containing 0.63 g of sodium cyanide, 1 mL of DMSO solution containing 1.00 g of 4-chloromethyl-2,6-dimethylpyridine was added under cooling with ice, and stirred at room temperature for 2 hours. Water was added to the reaction solution which was then extracted with ethyl acetate. The ethyl acetate extract was washed with water, dried over anhydrous magnesium sulfate and removed of the solvent by reduced pressure distillation to provide 0.86 g (yield: 92%) of the title compound as a reddish brown, oily substance. 1H-NMR(CDCl3)delta:7.01(s,2H),4.02(s,2H),2.49(s,6H) Mass,m/e:146(M+,base)
The chemical industry reduces the impact on the environment during synthesis 120739-87-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; ASKA Pharmaceutical Co., Ltd.; EP2036905; (2009); A1;,
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