Reference of 1207758-80-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1207758-80-2, name is 3-(5-Bromo-2-pyridyl)-3-oxetanol, molecular formula is C8H8BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of sodium carbonate (0.54 g, 5.08 mmol) dissolved in water (2.5 mL, 140 mmol) and 1,4-dioxane (6.10 mL, 78.2 mmol) is sonicated for 5 minutes then degassed with bubbling N2 for 15 min. The product of step 1-Example 8 (0.300 g, 1.30 mmol) and step 4-Example 8 (0.647 g, 1.56 mmol) are added successively. After addition, [1,1?-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.0668 g, 0.0913 mmol) is added and the reaction mixture heated at 60 C. for 2 hours before being cooled to room temperature and diluted with ethylacetate. The mixture is washed with water (20 mL), followed by brine (20 mL), dried over MgSO4 and the solvent removed under reduced pressure. The crude material is purified by chromatography eluting neat heptanes to 70% ethylacetate in hexanes to give the title compound (410 mg): m/z (CI) M+H 437.
According to the analysis of related databases, 1207758-80-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ZOETIS LLC; Billen, Denis; Curtis, Michael; Ewin, Richard Andrew; Goodwin, Richard M.; Johnson, Paul D.; Johnson, Timothy Allan; Kyne, Graham M.; Maddux, Todd M.; Sheehan, Susan Mary Kult; Vairagoundar, Rajendran; US2014/88046; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem