1211532-15-8 | Pyridine-derivatives

New downstream synthetic route of 1211532-15-8

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1211532-15-8, 6-Methoxy-5-(trifluoromethyl)nicotinic acid, other downstream synthetic routes, hurry up and to see.

Related Products of 1211532-15-8 ,Some common heterocyclic compound, 1211532-15-8, molecular formula is C8H6F3NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate 37: Synthesis of 6-hydroxy-5-(trifluoromethyl)nicotinic acid; To a solution of TMSCI (0.75 ml_, 5.88 mmol) in dry MeCN is added potassium iodide (0.98 g, 5.88 mmol). The crude is stirred at room temperature for 10 mins. To this crude is added a solution of 6-methoxy-5-(trifluoromethyl)nicotinic acid (1 .3 g, 5.88 mmol) in MeCN (2 ml_). The crude is stirred at 80 deg C for 4 hrs and room temperature for overnight. The crude is concentrated and diluted in ether and 1 N HCI. The organic layer is washed with water, brine, dried over MgSO4, filtered and concentrated. The crude is purified via RP-HPLC (SunFire C18, H2O(O. I 0ZoTFA)ZCH3CN) to give 6-hydroxy-5-(trifluoromethyl)nicotinic acid (377 mg). HPLC retention time = 0.85 minutes (condition B); MS 208.0 (M+1 ). 1 H NMR (400 MHz, CD3OD) delta ppm 8.34 (s, 2 H).

Reference:
Patent; NOVARTIS AG; COPPOLA, Gary Mark; IWAKI, Yuki; KARKI, Rajeshri Ganesh; KAWANAMI, Toshio; KSANDER, Gary Michael; MOGI, Muneto; SUN, Robert; WO2010/136474; (2010); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Introduction of a new synthetic route about 1211532-15-8

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1211532-15-8, 6-Methoxy-5-(trifluoromethyl)nicotinic acid.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1211532-15-8, name is 6-Methoxy-5-(trifluoromethyl)nicotinic acid. A new synthetic method of this compound is introduced below., Recommanded Product: 1211532-15-8

(5-bromopyridin-2-yl) ((2S) -2- (4-chlorophenyl) piperazin- 1 -yl) methanone hydrochloride (300 mg)6-methoxy-5- (trifluoromethyl) nicotinic acid (180 mg),HATU (0.4 g),A mixture of triethylamine (0.2 ml) and DMF (3 ml)And the mixture was stirred at room temperature for 2 hours.The mixture was extracted with ethyl acetate and water. The obtained organic layer was washed with saturated brine, dried over magnesium sulfate and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane / ethyl acetate) to give the title compound (338 mg).

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; MIZOJIRI, RYO; CARY, DOUGLAS ROBERT; HIRAYAMA, TAKAHARU; ITO, MASAHIRO; TANAKA, TOSHIO; IMAEDA, YASUHIRO; SASAKI, SHIGEKAZU; TAKAMI, KAZUAKI; FUKUDA, KOICHIRO; KAMAURA, MASAHIRO; MORISHITA, NAO; (133 pag.)JP2017/222626; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Brief introduction of 1211532-15-8

The synthetic route of 1211532-15-8 has been constantly updated, and we look forward to future research findings.

Reference of 1211532-15-8 , The common heterocyclic compound, 1211532-15-8, name is 6-Methoxy-5-(trifluoromethyl)nicotinic acid, molecular formula is C8H6F3NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation Example 4 To a mixture of 6-methoxy-5-(trifluoromethyl)nicotinic acid (7.8 g) and dichloromethane (80 mL) were added N,O-dimethylhydroxylamine hydrochloride (4.3 g), WSCD.HCl (9.5 g), and N,N-diisopropylethylamine (30 mL) under ice-cooling. The reaction mixture was stirred at room temperature for 17 hours. The reaction mixture was concentrated under reduced pressure, and to the residue were added ethyl acetate and water, followed by stirring for 30 minutes. The organic layer was separated, the aqueous layer was extracted with ethyl acetate, and the organic layer was combined, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain N,6-dimethoxy-N-methyl-5-(trifluoromethyl)nicotinamide (5.0 g) as an oil.

The synthetic route of 1211532-15-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Astellas Pharma Inc.; TAKAHASHI, Taisuke; KOIKE, Takanori; NEGORO, Kenji; TANAKA, Hiroaki; MAEDA, Jun; YOKOYAMA, Kazuhiro; TAKAMATSU, Hajime; (146 pag.)EP3153511; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extended knowledge of 6-Methoxy-5-(trifluoromethyl)nicotinic acid

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1211532-15-8, 6-Methoxy-5-(trifluoromethyl)nicotinic acid.

Reference of 1211532-15-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1211532-15-8, name is 6-Methoxy-5-(trifluoromethyl)nicotinic acid, molecular formula is C8H6F3NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

N,O-dimethylhydroxylamine hydrochloride (4.3 g), N-[3-(dimethylamino)propyl]-N?-ethylcarbodiimide hydrochloride(9.5 g), and N,N-diisopropylethylamine (30 mL) were added to a mixture of 6-methoxy-5-(trifluoromethyl)nicotinicacid (7.8 g) and methylene chloride (80 mL) under ice-cooling, and then the reaction mixture was stirred at room temperaturefor 17 hours. The reaction mixture was concentrated under reduced pressure, and to the residue were addedethyl acetate and water, followed by stirring for 30 minutes. The mixture was extracted with ethyl acetate, the organiclayer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residuewas purified by silica gel column chromatography (hexane-ethyl acetate) to N,6-dimethoxy-N-methyl-5-(trifluoromethyl)nicotinamide (5.0 g) as an oil.

Reference:
Patent; Astellas Pharma Inc.; TAKAHASHI, Taisuke; TANAKA, Hiroaki; AKAIWA, Michinori; NEGORO, Kenji; MIHARA, Hisashi; FUJI, Hideyoshi; TAKAMATSU, Hajime; (133 pag.)EP3196200; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extended knowledge of 6-Methoxy-5-(trifluoromethyl)nicotinic acid

The origin of a common compound about 6-Methoxy-5-(trifluoromethyl)nicotinic acid

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1211532-15-8, 6-Methoxy-5-(trifluoromethyl)nicotinic acid, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1211532-15-8, 6-Methoxy-5-(trifluoromethyl)nicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 6-Methoxy-5-(trifluoromethyl)nicotinic acid, blongs to pyridine-derivatives compound. Recommanded Product: 6-Methoxy-5-(trifluoromethyl)nicotinic acid

(4-bromophenyl) ((2S) -2- (4-chlorophenyl) piperazin-1-yl) methanone hydrochloride (2 g)6-methoxy-5- (trifluoromethyl) nicotinic acid (1.2 g),HATU (3 g),Triethylamine (2 ml)And DMF (15 ml) was stirred at room temperature for 1 hour. The mixture was extracted with ethyl acetate and water. The obtained organic layer was washed with saturated brine, dried over magnesium sulfate and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (NH, hexane / ethyl acetate) to give the title compound (2.9 g).