Application of 1211533-93-5, Adding some certain compound to certain chemical reactions, such as: 1211533-93-5, name is 5-Chloro-2-methyl-3-nitropyridine,molecular formula is C6H5ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1211533-93-5.
To a solution of 5-chloro-2-methyl-3-nitropyridine (26g, 15 1 mmol) in ethyl acetate (850mL) under nitrogen atmosphere was added SnC12.2H20 (136g, 603 mmol) at room temperature. The reaction mixture was heated to 85C for 3h. Concentration of the reaction mixture under reduced pressure afforded a pale yellow slurry which was basified with I N NaOH solution (520mL). The resulting mixture was diluted withdichloromethane (750mL) and stirred for 10 minutes. The mixture was then fi ltered through a celite pad to remove undissolved solids. The filtrate’s organic layer was separated, dried over anhydrous Na2S04 and concentrated under reduced pressure. The crude compound was purified by column chromatography on silica gel ( 100-200 mesh) using 0-35% ethyl acetate in petroleum ether to afford desired 5-chloro-2-methylpyridine- 3-amine (18 g) as a brown solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1211533-93-5, 5-Chloro-2-methyl-3-nitropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXOSMITHKLINE LLC; BOBKO, Mark, A.; DARCY, Michael, G.; EVANS, Karen, A.; FAITG, Thomas, H.; KAURA, Arun, Chandar; PENG, Xin; SARPONG, Martha, A.; SEEFELD, Mark, A.; SU, Dai-shi; WO2012/149102; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem