Category: 1214336-41-0

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1214336-41-0, name is Methyl 5-bromo-3-chloropicolinate, the common compound, a new synthetic route is introduced below. Computed Properties of C7H5BrClNO2

NaBH4 (18.24g, 480.Ommol) was added portion wise to a stirred solution of methyl 5-bromo-3-chloro-picolinate (20g, 80.Ommol) in dry THF (200mL) and MeOH (200m1) at 0C and stirred for 6 h at RT. TheRM was slowly quenched with water (500mL) and extracted with EtOAc (3x200mL). The organic layerwas washed with brine (300mL),then dried (Na2SO4), filtered and evaporated the solvent in vacuo to give(5-bromo-3-choropyridin-2-yl)methanol (16g,crude), as a thick liquid. The crude was taken into next step.

The synthetic route of 1214336-41-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GRUeNENTHAL GMBH; SCHUNK, Stefan; REICH, Melanie; JAKOB, Florian; DAMANN, Nils; HAURAND, Michael; KLESS, Achim; ROGERS, Marc; SUTTON, Kathy; WO2015/158427; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1214336-41-0, name is Methyl 5-bromo-3-chloropicolinate, the common compound, a new synthetic route is introduced below. Computed Properties of C7H5BrClNO2

NaBH4 (18.24g, 480.Ommol) was added portion wise to a stirred solution of methyl 5-bromo-3-chloro-picolinate (20g, 80.Ommol) in dry THF (200mL) and MeOH (200m1) at 0C and stirred for 6 h at RT. TheRM was slowly quenched with water (500mL) and extracted with EtOAc (3x200mL). The organic layerwas washed with brine (300mL),then dried (Na2SO4), filtered and evaporated the solvent in vacuo to give(5-bromo-3-choropyridin-2-yl)methanol (16g,crude), as a thick liquid. The crude was taken into next step.

The synthetic route of 1214336-41-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GRUeNENTHAL GMBH; SCHUNK, Stefan; REICH, Melanie; JAKOB, Florian; DAMANN, Nils; HAURAND, Michael; KLESS, Achim; ROGERS, Marc; SUTTON, Kathy; WO2015/158427; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1214336-41-0, Methyl 5-bromo-3-chloropicolinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: Methyl 5-bromo-3-chloropicolinate, blongs to pyridine-derivatives compound. name: Methyl 5-bromo-3-chloropicolinate

[013381 NaBH4 (6 g, 158.52 mmol, 3.97 equiv) was added to a solution of methyl 5-bromo-3- chloropyridine-2-carboxylate (10 g, 39.92 mmol, 1.00 equiv) in methanol (150 mL) at 0C. The reaction was stirred for 3 h at 0C. The reaction was then quenched by water, diluted with ethyl acetate, washed with saturated sodium bicarbonate and brine, dried over anhydrous sodium sulfate, and concentrated under vacuum. This resulted in the title compound (8.9 g, crude) as a light yellow solid. LCMS [M+H] 224.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1214336-41-0, Methyl 5-bromo-3-chloropicolinate, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ESTRADA, Anthony; VOLGRAF, Matthew; CHEN, Huifen; KOLESNIKOV, Aleksandr; VILLEMURE, Elisia; VERMA, Vishal; WANG, Lan; SHORE, Daniel; DO, Steven; YUEN, Po-wai; HU, Baihua; WU, Guosheng; LIN, Xingyu; LU, Aijun; (537 pag.)WO2016/128529; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1214336-41-0, Methyl 5-bromo-3-chloropicolinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: Methyl 5-bromo-3-chloropicolinate, blongs to pyridine-derivatives compound. name: Methyl 5-bromo-3-chloropicolinate

[013381 NaBH4 (6 g, 158.52 mmol, 3.97 equiv) was added to a solution of methyl 5-bromo-3- chloropyridine-2-carboxylate (10 g, 39.92 mmol, 1.00 equiv) in methanol (150 mL) at 0C. The reaction was stirred for 3 h at 0C. The reaction was then quenched by water, diluted with ethyl acetate, washed with saturated sodium bicarbonate and brine, dried over anhydrous sodium sulfate, and concentrated under vacuum. This resulted in the title compound (8.9 g, crude) as a light yellow solid. LCMS [M+H] 224.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1214336-41-0, Methyl 5-bromo-3-chloropicolinate, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ESTRADA, Anthony; VOLGRAF, Matthew; CHEN, Huifen; KOLESNIKOV, Aleksandr; VILLEMURE, Elisia; VERMA, Vishal; WANG, Lan; SHORE, Daniel; DO, Steven; YUEN, Po-wai; HU, Baihua; WU, Guosheng; LIN, Xingyu; LU, Aijun; (537 pag.)WO2016/128529; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem