The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1215860-20-0, name is Methyl 5-bromo-6-methylpicolinate. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C8H8BrNO2
5-bromo-6-methylpyridine-2-carboxylic acid methyl ester (2769 mg, 3.12 mmol), bis (pinacolato) – diborane (3274 mg, 12.9 mmol) and potassium acetate (2531 mg, 25.8 mmol) were initially charged in toluene (72 ml), flushed with argon and then treated with [l, l-bis (diphenylphosphine) ferrocene] – dichloropalladium-dichloromethane complex (351 mg, 0:43 mmol).The reaction mixture was heated for 3 h under reflux and then concentrated.The residue was dried under high vacuum and then taken up in 1,2-dimethoxyethane (72 ml) and ethanol (29 ml).This was followed by the addition of 4-bromo-Nu-[(trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]-L-phenylalanine(4155 mg, 8.6 mmol), [l, l-bis (diphenylphosphine) – ferrocene] -dichloropalladium-dichloromethane complex (351 mg, 0:43 mmol) and aqueous saturated sodium carbonate solution (8.6 mL).The reaction mixture was stirred for 6 h under reflux, concentrated and purified chromatographically by means of flash chromatography (ethyl acetate / ethanol gradient).This gave 2528 mg (38% d. Th., 73% purity) of the title compound.
With the rapid development of chemical substances, we look forward to future research findings about 1215860-20-0.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ROEHN, ULRIKE; ELLERMANN, MANUEL; STRASSBURGER, JULIA; WENDT, ASTRID; ROEHRIG, SUSANNE; WEBSTER, ROBERT ALAN; SCHMIDT, MARTINA VICTORIA; TERSTEEGEN, ADRIAN; BEYER, KRISTIN; SCHAEFER, MARTINA; BUCHMUELLER, ANJA; GERDES, CHRISTOPH; SPERZEL, MICHAEL; SANDMANN, STEFFEN; HILLISCH, ALEXANDER; ACKERSTAFF, JENS; TERJUNG, CARSTEN; (161 pag.)TW2016/5828; (2016); A;,
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