Category: 122368-54-1

Related Products of 122368-54-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 122368-54-1, name is 2-((4-Chlorophenyl)(piperidin-4-yloxy)methyl)pyridine. A new synthetic method of this compound is introduced below.

EXAMPLE 47 From 4-[(4-chlorophenyl)-2-pyridylmethoxy]piperidine and 5-chloro-2-pentanone, 5-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]-2-pentanone was obtained in the same procedure as described in Example 26. Mass analysis value: EI-MS M+ no peak, CI-MS m/e=387(M+ +1). 1 H-NMR(CDCl3): delta(ppm)=1.60-1.95(6H,b,m), 2.08(2H,b), 2.14(3H,s), 2.27(2H,t), 2.43(2H,t), 2.70(2H,b), 3.44(1H,m), 5.59(1H,s), 7.11-7.71(7H,m), 8.50(1H,m).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,122368-54-1, its application will become more common.

Reference:
Patent; Ube Industries, Ltd.; US4929618; (1990); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 122368-54-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 122368-54-1, name is 2-((4-Chlorophenyl)(piperidin-4-yloxy)methyl)pyridine. A new synthetic method of this compound is introduced below.

EXAMPLE 47 From 4-[(4-chlorophenyl)-2-pyridylmethoxy]piperidine and 5-chloro-2-pentanone, 5-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]-2-pentanone was obtained in the same procedure as described in Example 26. Mass analysis value: EI-MS M+ no peak, CI-MS m/e=387(M+ +1). 1 H-NMR(CDCl3): delta(ppm)=1.60-1.95(6H,b,m), 2.08(2H,b), 2.14(3H,s), 2.27(2H,t), 2.43(2H,t), 2.70(2H,b), 3.44(1H,m), 5.59(1H,s), 7.11-7.71(7H,m), 8.50(1H,m).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,122368-54-1, its application will become more common.

Reference:
Patent; Ube Industries, Ltd.; US4929618; (1990); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 122368-54-1, 2-((4-Chlorophenyl)(piperidin-4-yloxy)methyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 122368-54-1, blongs to pyridine-derivatives compound. Product Details of 122368-54-1

To 10 mL of DMF were added 0.5 g of vanillic acid, 0.51 g of EDC, 0.44 g of HOBt, 1.44 mL of TEA and 0.99 g of 2-[(4-chlorophenyl)(4-piperidinyloxy)methyl]pyridine, and the mixture was stirred at 60 to 80C for 4 hours. 10 mL of EtOAc and 10 mL of purified water were added to the reaction mixture and the layers were separated. The aqueous layer was extracted once with 10 mL of EtOAc and the aqueous layer was discarded. The organic layer was washed three times with 10 mL of purified water, dried over Na2SO4 and filtered. The filtrate was distilled under reduced pressure and purified by flash column chromatography to obtain 0.40 g of the title compound as a pale yellow solid. Yield: 31.6% 1H NMR (400MHz, DMSO-d6) delta 9.41 (brs, 1H), 8.47 (d, J = 4.0 Hz, 1H), 7.81 (t, J = 7.0, 1H), 7.57(d, J = 8.0 Hz, 1H), 7.44?6.94(m, 6H), 6.84?6.67(m, 3H), 5.71(s, 1H), 3.87(s, 3H), 3.74?3.69(m, 2H), 3.37(brs, 2H), 1.85(brs, 2H), 1.72(brs, 2H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,122368-54-1, its application will become more common.

Reference:
Patent; Shin Poong Pharmaceutical Co., Ltd.; RYU, JeiMan; LEE, Dong Won; LEE, Kang Hyeok; PARK, Jin Hun; CHO, Geum Sil; LEE, Ki Sung; CHUNG, Jin Ho; PARK, Woo Ile; LEE, Jae Young; (35 pag.)EP3345910; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem