Category: 122637-39-2

Novel Thiazole Derivatives as Inhibitors of Superoxide Production by Human Neutrophils: Synthesis and Structure-Activity Relationships was written by Chihiro, Masatoshi;Nagamoto, Hisashi;Takemura, Isao;Kitano, Kazuyoshi;Komatsu, Hajime;Sekiguchi, Kazuo;Tabusa, Fujio;Mori, Toyoki;Tominaga, Michiaki;Yabuuchi, Youichi. And the article was included in Journal of Medicinal Chemistry in 1995.Name: 6-Acetylpicolinic acid This article mentions the following:

Neutrophils have an important role in the self-defense systems of organisms through the production of superoxide. On the other hand, it has been proposed that abnormal amounts of superoxide produced by neutrophils are a serious factor in tissue injury. A series of novel thiazole derivatives was prepared and evaluated for inhibitory effect on superoxide production by human neutrophils in vitro. Among these compounds, 6-[2-(3,4-diethoxyphenyl)thiazol-4-yl]pyridine-2-carboxylic acid (OPC-6535) was selected as one of the most promising compounds In the experiment, the researchers used many compounds, for example, 6-Acetylpicolinic acid (cas: 122637-39-2Name: 6-Acetylpicolinic acid).

6-Acetylpicolinic acid (cas: 122637-39-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Name: 6-Acetylpicolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Polynuclear lanthanide complexes of a series of bridging ligands containing two tridentate N,N’,O-donor units: structures and luminescence properties was written by Ronson, Tanya K.;Adams, Harry;Harding, Lindsay P.;Pope, Simon J. A.;Sykes, Daniel;Faulkner, Stephen;Ward, Michael D.. And the article was included in Dalton Transactions in 2007.Quality Control of 6-Acetylpicolinic acid This article mentions the following:

A set of three potentially bridging ligands containing two tridentate chelating N,N’,O-donor (pyrazole-pyridine-amide) donors separated by an o- (I = L²), m- (L³), or p-phenylene (L¹) spacer has been prepared and their coordination chem. with lanthanide(III) ions investigated. Ligand L¹ forms complexes with a 2:3 M:L ratio according to the proportions used in the reaction mixture The Ln₂(L¹)₃ complexes contain two 9-coordinate Ln(III) centers with all three bridging ligands spanning both metal ions and have a cylindrical (non-helical) ‘mesocate’ architecture. The 1:1 complexes display a range of structural types depending on the conditions used including a cyclic Ln₄(L¹)₄ tetranuclear helicate, a Ln₂(L¹)₂ dinuclear mesocate and an infinite one-dimensional coordination polymer in which metal ions and bridging ligands alternate along the sequence. ESMS studies indicate that the 1:1 complexes form a mixture of oligonuclear species {Ln(L¹)}_n in solution (n up to 5) which are likely to be cyclic helicates. In contrast, ligands L² and L³ generally form dinuclear Ln₂L₂ Ln(III) complexes in which the two ligands may be arranged in a helical or non-helical architecture about the two metal ions. These complexes also contain an addnl. exogenous bidentate bridging ligand, either acetate or formate, which has arisen from hydrolysis of solvent mols. promoted by the Lewis-acidity of the Ln(III) ions. Luminescence studies on some of the Nd(III) complexes showed that excitation into ligand-centered 锜?锜? transitions result in the characteristic near-IR luminescence from Nd(III) at 1060 nm. In the experiment, the researchers used many compounds, for example, 6-Acetylpicolinic acid (cas: 122637-39-2Quality Control of 6-Acetylpicolinic acid).

6-Acetylpicolinic acid (cas: 122637-39-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of 6-Acetylpicolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Copper(II)-hydroxide facilitated C-C bond formation: the carboxamido pyridine system versus the methylimino pyridine system was written by Li, Yinghua;Fan, Weibin;Zhang, Zilong;Xie, Xingkun;Xiang, Shiqun;Huang, Deguang. And the article was included in Dalton Transactions in 2020.Related Products of 122637-39-2 This article mentions the following:

A copper(II)-hydroxide-induced carbon-carbon bond formation reaction is explored with the synthesis of an asym. carboxamido-methylimino pyridine Cu(I) complex of [Cu^I(py(N-CO)(NC-C)ph₂^Me2)₂]^– (12). Two imine-Me groups are coupled to form a bridged C-C bond (NC-C-C-CN) at the Me positions with the reduction of two Cu²⁺ center ions to Cu⁺. The reaction is checked with three dicarboxamido pyridine [Cu^II-OH] complexes, with which dinuclear Cu(I) complexes of [Cu₂(py(N-CO)₂ph₂^R2)₂]^2- (R = Me (3), Me and allyl (6)) and trinuclear [Cu^II-Cu^I-Cu^II] complex of [Cu₃(閳?sub>20-py(N-CO)₂ph₂dien^Me3)₂]⁺ (9) are obtained. The reactivities of the [Cu^II-L] (L = DMF, OH^–) complexes in dicarboxamido pyridine, carboxamido-methylimino pyridine and dimethylimino pyridine systems are discussed in terms of the electron delocalization properties of ligands. A cooperative metal-ligand (Cu²⁺ and enamide ligand) interaction is proposed based on the characterization of ligated Cu(II) intermediates with the techniques of x-ray crystallog., UV-vis spectroscopy, cyclic voltammogram, EPR spectroscopy, and DFT calculations In the experiment, the researchers used many compounds, for example, 6-Acetylpicolinic acid (cas: 122637-39-2Related Products of 122637-39-2).

6-Acetylpicolinic acid (cas: 122637-39-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Related Products of 122637-39-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem