Category: 1226878-98-3

Synthetic Route of 1226878-98-3, Adding some certain compound to certain chemical reactions, such as: 1226878-98-3, name is 2-Chloro-5-iodo-4-methoxypyridine,molecular formula is C6H5ClINO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1226878-98-3.

General procedure: The appropriate 5-iodo-2-chloropyridine Intermediate I-8, or I-9 (1 eq) was dissolved in acetonitrile (7 ml. solvent per 1 mmol of compound). 1 -Methyl-4-(4,4,5,5-tetramethyl- 1 ,3,2-dioxaborolan-2-yl)-1 H-pyrazole (1 eq), tetrakis – (triphenylphosphine)palladium(O) (5 mol%) and sodium carbonate (1 .5 eq) were added and the mixture was heated in a microwave reactor at 100C for 30 minutes (Intermediate I-8) or 15 minutes (Intermediate I-9). The reaction mixture was concentrated in vacuo onto silica gel. Gradient chromatography (1-5% MeOH:CH2CI over 15 column volume and 5-10% over 8 column volume) gave the required 5-substituted product.

According to the analysis of related databases, 1226878-98-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; COLLINS, Ian; LAINCHBURY, Michael; MATTHEWS, Thomas Peter; READER, John Charles; WO2013/68755; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1226878-98-3 , The common heterocyclic compound, 1226878-98-3, name is 2-Chloro-5-iodo-4-methoxypyridine, molecular formula is C6H5ClINO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

j00505j To a solution of compound B-116 (4.0 g, 7.4 mmol) in acetic acid (30 mL) was added hydrogen bromide (40% in water, 23 g, 11 immol). The vessel was sealed and heated to 110 C for 4 hours. On completion, the mixture was concentrated in vacuo. The residue was dissolved in methanol (20 mL) and triethylamine (20 mL), concentrated again in vacuo and purified by silica gel chromatography [dichloromethane: methanol = 30:11 to give compound B-117 (3.0 g, 75% yield) as a white solid. ?H-NMR (CD3OD, 400 MHz): 8.33 (s, 1H), 6.73 (s, 1H).

The synthetic route of 1226878-98-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FORUM PHARMACEUTICALS, INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; McRINER, Andrew, J.; (267 pag.)WO2017/69980; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem