Category: 1227002-03-0

Yu, Henry et al. published their patent in 2019 |CAS: 1227002-03-0

The Article related to oxazepanyl pyrimidinamine preparation antiproliferative antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Recommanded Product: 1227002-03-0

On October 24, 2019, Yu, Henry; Clark, Michael; Bemis, Guy; Boyd, Michael; Chandupatla, Kishan; Collier, Philip; Deng, Hongbo; Dong, Huijun; Dorsch, Warren; Hoover, Russell R.; Johnson, Mac Arthur, Jr.; Kukarni, Shashank; Penney, Marina; Ronkin, Steven; Takemoto, Darin; Tang, Qing; Waal, Nathan D.; Wang, Tiansheng published a patent.Recommanded Product: 1227002-03-0 The title of the patent was Preparation of substituted oxazepanyl pyrimidinamines as antiproliferation compounds. And the patent contained the following:

The present invention provides compounds I [ring A = Ph, 5-7 membered saturated or partially unsaturated carbocyclic ring, 8-12 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-2 heteroatoms independently selected from N, O, or S, etc.; each R1 = (independently) H, or (halo)alkyl; or two R1 groups are optionally taken together with their intervening atoms to form 5-8 membered partially unsaturated fused carbocyclic ring; each of R2 = (independently) H, halo, CN, etc.; or two R2 groups are optionally taken together to form :O; or two R2 groups are optionally taken together with their intervening atoms to form 3-8 membered saturated spirocyclic ring having 0-2 heteroatoms independently selected from N, O or S; each R3 = (independently) H, OH, or alkyl; or two R3 groups are optionally taken together to form :O or :CH2; or two R3 groups are optionally taken together with their intervening atoms to form 3-8 membered saturated spirocyclic ring having 0-2 heteroatoms independently selected from N, O or S; or 5-8 membered saturated bridged bicyclic ring having 0-2 heteroatoms independently selected from N, O or S; X = O, S, CH2, etc.; m = 0-2; n = 0-5; p = 0-2] or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer). E.g., a multi-step synthesis of (R)-II and (S)-II, starting from 3-(tributylstannylmethoxy)propan-1-amine and 2-chloro-5-nitrobenzaldehyde, was described. Exemplified compounds I were evaluated in the Colo 205 reporter assay, HepG2 XBP1 reporter assay, and in the Calcium Flux assay (data given for representative compounds I). The experimental process involved the reaction of Methyl 2-amino-5-chloroisonicotinate(cas: 1227002-03-0).Recommanded Product: 1227002-03-0

The Article related to oxazepanyl pyrimidinamine preparation antiproliferative antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Recommanded Product: 1227002-03-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Maue, Michael et al. published their patent in 2010 |CAS: 1227002-03-0

The Article related to halogen substituted compound preparation pesticide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 1227002-03-0

On November 25, 2010, Maue, Michael; Adelt, Isabelle; Giencke, Wolfgang; Heil, Markus; Jeschke, Peter; Kapferer, Tobias; Krueger, Bernd-Wieland; Muehltau, Friedrich August; Sudau, Alexander; Adamczewski, Martin; Drewes, Mark Wilhelm; Ebbinghaus-Kintscher, Ulrich; Raming, Klaus; Voerste, Arnd; Franken, Eva-Maria; Becker, Angela; Goergens, Ulrich published a patent.Synthetic Route of 1227002-03-0 The title of the patent was Preparation of halogen-substituted compounds as pesticides. And the patent contained the following:

The invention relates to halogen-substituted compounds of formula I and to the use of these compounds for controlling animal pests. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula I. Compounds of formula I wherein R1 is H, (un)substituted C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, etc.; A1 is CR2, G, G-amino, G-oxy and G-thio; A2 is CR3, G, G-amino, G-oxy and G-thio; A4 is CR4, G, G-amino, G-oxy and G-thio; A5 is CR5, G, G-amino, G-oxy and G-thio; R2, R3, R4 and R5 are independently H, halo, CN, NO2, (un)substituted C1-6 alkyl, etc.; G is H, (un)substituted C1-6 alkyl, C1-4 alkenyl, C1-4 alkynyl, C1-6 haloalkyl, etc.; U is CO, CS, SO and SO2; L is CONH, and derivatives, and CONHSO2; Q is (un)substituted Ph and (un)substituted pyridinyl; T is substituted thienyl, substituted azolyl, substituted furanyl, etc.; m is 1; are claimed. Example compound II was prepared by chlorination of 2-pentafluoroethyl-4-trifluoromethylpyrimidine-5-carboxylic acid; the resulting 2-pentafluoroethyl-4-trifluoromethylpyrimidine-5-carbonyl chloride underwent amidation with 5-amino-2-chloro-N-(3-chlorophenyl)benzamide to give compound II. All the invention compounds were evaluated for their pesticidal activity (some data given). The experimental process involved the reaction of Methyl 2-amino-5-chloroisonicotinate(cas: 1227002-03-0).Synthetic Route of 1227002-03-0

The Article related to halogen substituted compound preparation pesticide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 1227002-03-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yu, Henry et al. published their patent in 2019 |CAS: 1227002-03-0

The Article related to oxazepanyl pyrimidinamine preparation antiproliferative antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Recommanded Product: 1227002-03-0

On October 24, 2019, Yu, Henry; Clark, Michael; Bemis, Guy; Boyd, Michael; Chandupatla, Kishan; Collier, Philip; Deng, Hongbo; Dong, Huijun; Dorsch, Warren; Hoover, Russell R.; Johnson, Mac Arthur, Jr.; Kukarni, Shashank; Penney, Marina; Ronkin, Steven; Takemoto, Darin; Tang, Qing; Waal, Nathan D.; Wang, Tiansheng published a patent.Recommanded Product: 1227002-03-0 The title of the patent was Preparation of substituted oxazepanyl pyrimidinamines as antiproliferation compounds. And the patent contained the following:

The present invention provides compounds I [ring A = Ph, 5-7 membered saturated or partially unsaturated carbocyclic ring, 8-12 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-2 heteroatoms independently selected from N, O, or S, etc.; each R1 = (independently) H, or (halo)alkyl; or two R1 groups are optionally taken together with their intervening atoms to form 5-8 membered partially unsaturated fused carbocyclic ring; each of R2 = (independently) H, halo, CN, etc.; or two R2 groups are optionally taken together to form :O; or two R2 groups are optionally taken together with their intervening atoms to form 3-8 membered saturated spirocyclic ring having 0-2 heteroatoms independently selected from N, O or S; each R3 = (independently) H, OH, or alkyl; or two R3 groups are optionally taken together to form :O or :CH2; or two R3 groups are optionally taken together with their intervening atoms to form 3-8 membered saturated spirocyclic ring having 0-2 heteroatoms independently selected from N, O or S; or 5-8 membered saturated bridged bicyclic ring having 0-2 heteroatoms independently selected from N, O or S; X = O, S, CH2, etc.; m = 0-2; n = 0-5; p = 0-2] or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer). E.g., a multi-step synthesis of (R)-II and (S)-II, starting from 3-(tributylstannylmethoxy)propan-1-amine and 2-chloro-5-nitrobenzaldehyde, was described. Exemplified compounds I were evaluated in the Colo 205 reporter assay, HepG2 XBP1 reporter assay, and in the Calcium Flux assay (data given for representative compounds I). The experimental process involved the reaction of Methyl 2-amino-5-chloroisonicotinate(cas: 1227002-03-0).Recommanded Product: 1227002-03-0

The Article related to oxazepanyl pyrimidinamine preparation antiproliferative antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Recommanded Product: 1227002-03-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Maue, Michael et al. published their patent in 2010 |CAS: 1227002-03-0

The Article related to halogen substituted compound preparation pesticide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 1227002-03-0

On November 25, 2010, Maue, Michael; Adelt, Isabelle; Giencke, Wolfgang; Heil, Markus; Jeschke, Peter; Kapferer, Tobias; Krueger, Bernd-Wieland; Muehltau, Friedrich August; Sudau, Alexander; Adamczewski, Martin; Drewes, Mark Wilhelm; Ebbinghaus-Kintscher, Ulrich; Raming, Klaus; Voerste, Arnd; Franken, Eva-Maria; Becker, Angela; Goergens, Ulrich published a patent.Synthetic Route of 1227002-03-0 The title of the patent was Preparation of halogen-substituted compounds as pesticides. And the patent contained the following:

The invention relates to halogen-substituted compounds of formula I and to the use of these compounds for controlling animal pests. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula I. Compounds of formula I wherein R1 is H, (un)substituted C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, etc.; A1 is CR2, G, G-amino, G-oxy and G-thio; A2 is CR3, G, G-amino, G-oxy and G-thio; A4 is CR4, G, G-amino, G-oxy and G-thio; A5 is CR5, G, G-amino, G-oxy and G-thio; R2, R3, R4 and R5 are independently H, halo, CN, NO2, (un)substituted C1-6 alkyl, etc.; G is H, (un)substituted C1-6 alkyl, C1-4 alkenyl, C1-4 alkynyl, C1-6 haloalkyl, etc.; U is CO, CS, SO and SO2; L is CONH, and derivatives, and CONHSO2; Q is (un)substituted Ph and (un)substituted pyridinyl; T is substituted thienyl, substituted azolyl, substituted furanyl, etc.; m is 1; are claimed. Example compound II was prepared by chlorination of 2-pentafluoroethyl-4-trifluoromethylpyrimidine-5-carboxylic acid; the resulting 2-pentafluoroethyl-4-trifluoromethylpyrimidine-5-carbonyl chloride underwent amidation with 5-amino-2-chloro-N-(3-chlorophenyl)benzamide to give compound II. All the invention compounds were evaluated for their pesticidal activity (some data given). The experimental process involved the reaction of Methyl 2-amino-5-chloroisonicotinate(cas: 1227002-03-0).Synthetic Route of 1227002-03-0

The Article related to halogen substituted compound preparation pesticide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 1227002-03-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Austin et al. published their patent in 2016 |CAS: 1227002-03-0

The Article related to thiobenzamide preparation antiviral treatment hbv infection, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Safety of Methyl 2-amino-5-chloroisonicotinate

On June 9, 2016, Chen, Austin; Bravo, Yalda; Stock, Nicholas; Pedram, Bijan; Jacintho, Jason; Clark, Ryan C.; Truong, Yen published a patent.Safety of Methyl 2-amino-5-chloroisonicotinate The title of the patent was Thio-substituted benzamides as antiviral agents for the treatment of treatment HBV infection and their preparation. And the patent contained the following:

The invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of formula I. Compounds of formula I wherein each R1, R2, and R3 are halo; R4 is (un)substituted C3-7 cycloalkyl (un)substituted C1-6 alkyl-C3-7 cycloalkyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by thioetherification of N-(3,4,5-trifluoromethylphenyl)-4-fluoro-3-iodobenzamide with 1-(mercaptomethyl)cyclopropylacetic acid. The invention compounds were evaluated for their antiviral activity (some data given). The experimental process involved the reaction of Methyl 2-amino-5-chloroisonicotinate(cas: 1227002-03-0).Safety of Methyl 2-amino-5-chloroisonicotinate

The Article related to thiobenzamide preparation antiviral treatment hbv infection, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Safety of Methyl 2-amino-5-chloroisonicotinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sources of common compounds: Methyl 2-amino-5-chloroisonicotinate

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1227002-03-0, Methyl 2-amino-5-chloroisonicotinate, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1227002-03-0, Methyl 2-amino-5-chloroisonicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: Methyl 2-amino-5-chloroisonicotinate, blongs to pyridine-derivatives compound. Recommanded Product: Methyl 2-amino-5-chloroisonicotinate

The reaction with methyl 2-amino-5-chloroisonicotinate takes place analogously to the reaction procedure in Example (Ik-127) using: 601 mg (3.21 mmol) of methyl 2-amino-5-chloroisonicotinate in 28.0 ml of dichloromethane, 1064 mg (3.21 mmol) of 1-methyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride, 431 mg of silver(I) cyanide in 28.0 ml of acetonitrile. The remaining residue is purified by means of column chromatography on silica gel using the eluent mixture cyclohexane:acetone (gradient). This gives 563 mg of methyl 5-chloro-2-({[1-methyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)-isonicotinate (36%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1227002-03-0, Methyl 2-amino-5-chloroisonicotinate, and friends who are interested can also refer to it.

Reference:
Patent; Bayer CropScience AG; US2011/301181; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of 1227002-03-0

With the rapid development of chemical substances, we look forward to future research findings about 1227002-03-0.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1227002-03-0, name is Methyl 2-amino-5-chloroisonicotinate. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C7H7ClN2O2

To a solution of methyl 2-amino-5-chloroisonicotinate (4.75 g, 25.5 mmol) in DMF (40 mL) was added 4-(dimethylamino)pyridine (0.466 g, 3.82 mmol), triethylamine (10.62 mL, 76 mmol), and di-tert-butyl dicarbonate (16.67 g, 76 mmol). The reaction was stirred at room temperature for 3 d. The reaction was quenched with water (40 mL). The aqueous layer was extracted with EtOAc (100 mL, three times), and the combined organic layers were washed with water, brine, dried (MgS04) and concentrated. The residue was purified by flash chromatography (80 g silica gel column, gradient elution from hexanes to 15% EtOAc/hexanes) to provide bis-Boc aminopyridine (6.36 g, 16.44 mmol) as a white powder.

With the rapid development of chemical substances, we look forward to future research findings about 1227002-03-0.

Reference:
Patent; AMGEN INC.; ASHTON, Kate; BARTBERGER, Michael D.; BOURBEAU, Matthew Paul; CROGHAN, Michael D.; FOTSCH, Christopher H.; HUNGATE, Randall W.; KONG, Ke; NISHIMURA, Nobuko; NORMAN, Mark H.; PENNINGTON, Lewis D.; REICHELT, Andreas; SIEGMUND, Aaron C.; TADESSE, Seifu; ST. JEAN, David Jr; YANG, Kevin C.; YAO, Guomin; WO2013/173382; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of 1227002-03-0

With the rapid development of chemical substances, we look forward to future research findings about 1227002-03-0.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1227002-03-0, name is Methyl 2-amino-5-chloroisonicotinate. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C7H7ClN2O2

To a solution of methyl 2-amino-5-chloroisonicotinate (4.75 g, 25.5 mmol) in DMF (40 mL) was added 4-(dimethylamino)pyridine (0.466 g, 3.82 mmol), triethylamine (10.62 mL, 76 mmol), and di-tert-butyl dicarbonate (16.67 g, 76 mmol). The reaction was stirred at room temperature for 3 d. The reaction was quenched with water (40 mL). The aqueous layer was extracted with EtOAc (100 mL, three times), and the combined organic layers were washed with water, brine, dried (MgS04) and concentrated. The residue was purified by flash chromatography (80 g silica gel column, gradient elution from hexanes to 15% EtOAc/hexanes) to provide bis-Boc aminopyridine (6.36 g, 16.44 mmol) as a white powder.

With the rapid development of chemical substances, we look forward to future research findings about 1227002-03-0.

Reference:
Patent; AMGEN INC.; ASHTON, Kate; BARTBERGER, Michael D.; BOURBEAU, Matthew Paul; CROGHAN, Michael D.; FOTSCH, Christopher H.; HUNGATE, Randall W.; KONG, Ke; NISHIMURA, Nobuko; NORMAN, Mark H.; PENNINGTON, Lewis D.; REICHELT, Andreas; SIEGMUND, Aaron C.; TADESSE, Seifu; ST. JEAN, David Jr; YANG, Kevin C.; YAO, Guomin; WO2013/173382; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of 1227002-03-0

With the rapid development of chemical substances, we look forward to future research findings about 1227002-03-0.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1227002-03-0, name is Methyl 2-amino-5-chloroisonicotinate. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C7H7ClN2O2

To a solution of methyl 2-amino-5-chloroisonicotinate (4.75 g, 25.5 mmol) in DMF (40 mL) was added 4-(dimethylamino)pyridine (0.466 g, 3.82 mmol), triethylamine (10.62 mL, 76 mmol), and di-tert-butyl dicarbonate (16.67 g, 76 mmol). The reaction was stirred at room temperature for 3 d. The reaction was quenched with water (40 mL). The aqueous layer was extracted with EtOAc (100 mL, three times), and the combined organic layers were washed with water, brine, dried (MgS04) and concentrated. The residue was purified by flash chromatography (80 g silica gel column, gradient elution from hexanes to 15% EtOAc/hexanes) to provide bis-Boc aminopyridine (6.36 g, 16.44 mmol) as a white powder.

With the rapid development of chemical substances, we look forward to future research findings about 1227002-03-0.

Reference:
Patent; AMGEN INC.; ASHTON, Kate; BARTBERGER, Michael D.; BOURBEAU, Matthew Paul; CROGHAN, Michael D.; FOTSCH, Christopher H.; HUNGATE, Randall W.; KONG, Ke; NISHIMURA, Nobuko; NORMAN, Mark H.; PENNINGTON, Lewis D.; REICHELT, Andreas; SIEGMUND, Aaron C.; TADESSE, Seifu; ST. JEAN, David Jr; YANG, Kevin C.; YAO, Guomin; WO2013/173382; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem