122851-69-8 | Pyridine-derivatives

New learning discoveries about 3-Bromo-2-(chloromethyl)pyridine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,122851-69-8, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 122851-69-8, 3-Bromo-2-(chloromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 122851-69-8, blongs to pyridine-derivatives compound. Quality Control of 3-Bromo-2-(chloromethyl)pyridine

A solution of cis-4-(2,5-difluorophenyl)cyclohexanol (2.85 g) in THF (60 ml) wascooled to 0C, 60% sodium hydride (1.074 g) was added, and the mixture was stirredunder a calcium chloride tube dry atmosphere at room temperature for 2 hr. To thereaction mixture was added 3-bromo-2-(chloromethyl)pyridine (3.60 g), and themixture was stirred at room temperature for 30 min and at 70C for 3 hr. Water wasadded to the mixture at room temperature, and the mixture was extracted with ethylacetate. The organic layer was washed with water and saturated brine, dried overanhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. Theresidue was purified by silica gel chromatography (ethyl acetate/hexane) to give thetitle compound ( 4.33 g).MS, found: 382.0,383.9.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,122851-69-8, its application will become more common.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FUJIMOTO Tatsuhiko; RIKIMARU Kentaro; FUKUDA Koichiro; SUGIMOTO Hiromichi; MATSUMOTO Takahiro; TOKUNAGA Norihito; HIROZANE Mariko; (166 pag.)WO2017/135306; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of 122851-69-8

At the same time, in my other blogs, there are other synthetic methods of this type of compound,122851-69-8, 3-Bromo-2-(chloromethyl)pyridine, and friends who are interested can also refer to it.

Synthetic Route of 122851-69-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 122851-69-8, name is 3-Bromo-2-(chloromethyl)pyridine. A new synthetic method of this compound is introduced below.

A solution of cis-4-(2,3,6-trifluorophenyl)cyclohexanol (3.66 g) in THF (100 ml)was cooled to 0C, 60% sodium hydride (1.272 g) was added, and the mixture wasstirred under a calcium chloride tube dry atmosphere at room temperature for 10 min.To the reaction mixture was added 3-bromo-2-(chloromethyl)pyridine (4.92 g), and themixture was stirred at 70C for 3 hr. Water was added to the mixture at room temperature,and the mixture was extracted with ethyl acetate. The organic layer waswashed with saturated brine, dried over anhydrous sodium sulfate, and the solvent wasevaporated under reduced pressure. The residue was purified by silica gel chromatography(ethyl acetate/hexane) to give the title compound (3.73 g).MS, found: 401.0,403.0.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,122851-69-8, 3-Bromo-2-(chloromethyl)pyridine, and friends who are interested can also refer to it.

New learning discoveries about 3-Bromo-2-(chloromethyl)pyridine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,122851-69-8, its application will become more common.

A new synthetic route of 122851-69-8

At the same time, in my other blogs, there are other synthetic methods of this type of compound,122851-69-8, 3-Bromo-2-(chloromethyl)pyridine, and friends who are interested can also refer to it.

Extracurricular laboratory: Synthetic route of 3-Bromo-2-(chloromethyl)pyridine

Statistics shows that 122851-69-8 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-2-(chloromethyl)pyridine.

Reference of 122851-69-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.122851-69-8, name is 3-Bromo-2-(chloromethyl)pyridine, molecular formula is C6H5BrClN, molecular weight is 206.47, as common compound, the synthetic route is as follows.

A solution of cis-4-(2,6-difluorophenyl)cyclohexanol (2.69 g) in THF (60 ml) wascooled to 0C, 60% sodium hydride (1.014 g) was added, and the mixture was stirredunder a calcium chloride tube dry atmosphere for 2 hr. To the reaction mixture wasadded 3-bromo-2-(chloromethyl)pyridine (3.40 g), and the mixture was stirred at roomtemperature for 30 min, and at 70C overnight. Water was added to the mixture atroom temperature, and the mixture was extracted with ethyl acetate. The organic layerwas washed with water and saturated brine, dried over anhydrous magnesium sulfate,and the solvent was evaporated under reduced pressure. The residue was purified bysilica gel chromatography (ethyl acetate/hexane) to give the title compound (3.96 g).MS, found: 382.0,384.0.

Statistics shows that 122851-69-8 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-2-(chloromethyl)pyridine.

The origin of a common compound about 3-Bromo-2-(chloromethyl)pyridine

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 122851-69-8, 3-Bromo-2-(chloromethyl)pyridine.

Synthetic Route of 122851-69-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 122851-69-8, name is 3-Bromo-2-(chloromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

A solution of cis-4-(3-fluorophenyl)cyclohexanol (1.0 g) in THF (20 ml) was cooledto 0C, 60% sodium hydride (0.412 g) was added, and the mixture was stirred under acalcium chloride tube dry atmosphere for 1 hr. To the reaction mixture was added3-bromo-2-(chloromethyl)pyridine (1.382 g), and the mixture was stirred at room temperaturefor 2 hr, and at 70C for 2.5 hr. To the mixture was added saturated aqueousammonium chloride solution at room temperature, and the mixture was extracted withethyl acetate. The organic layer was washed with saturated brine, dried over anhydroussodium sulfate, and the solvent was evaporated under reduced pressure. The residuewas purified by silica gel chromatography (ethyl acetate/hexane) to give the titlecompound (1.580 g).MS, found: 363.9,365.9.

The origin of a common compound about 3-Bromo-2-(chloromethyl)pyridine

The important role of 3-Bromo-2-(chloromethyl)pyridine

According to the analysis of related databases, 122851-69-8, the application of this compound in the production field has become more and more popular.

Related Products of 122851-69-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 122851-69-8, name is 3-Bromo-2-(chloromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of cis-4-(2-methoxyphenyl)cyclohexanol (889 mg) in THF (20 ml) wasadded 60% sodium hydride (345 mg) at 0C, and the mixture was stirred at under anitrogen atmosphere at room temperature for 2 hr. To the reaction mixture was added3-bromo-2-(chloromethyl)pyridine (1.16 g), and the mixture was stirred at room temperaturefor 2 hr, and at 70C for 3 hr. To the reaction mixture was added water, andthe mixture was extracted with ethyl acetate. The obtained organic layer was washedsuccessively with water and saturated brine, dried over anhydrous magnesium sulfate,and the solvent was evaporated under reduced pressure. The residue was purified bysilica gel column chromatography (ethyl acetate/hexane) to give the title compound(743 mg).MS, found: 376.0,378.0.

According to the analysis of related databases, 122851-69-8, the application of this compound in the production field has become more and more popular.