Category: 1228880-68-9

Application of 1228880-68-9, Adding some certain compound to certain chemical reactions, such as: 1228880-68-9, name is Methyl 3-bromo-5-methylpicolinate,molecular formula is C8H8BrNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1228880-68-9.

Step A: Methyl 3-fluoro-5′-methyl-[2,3′-bipyridine]-2′-carboxylate. In a sealed tube 3-fluoro-2-(tributylstannyl)pyridine (2.87 g, 6.9 mmol) was added to a stirred solution of methyl 3-bromo-5-methylpicolinate (1.46 g, 6.3 mmol), Pd(PPh3)4 (367 mg, 0.3 mmol), copper(I) iodide (60 mg, 0.3 mmol) and lithium chloride (267 mg, 6.3 mmol) in toluene (19 mL) while the solution was bubbled with nitrogen. The reaction mixture was stirred at 120 C. overnight and then diluted with water and extracted with ethyl acetate. The organic layers were dried over MgSO4, filtered and concentrated. The crude was purified via silica gel chromatography (0-4% MeOH in DCM) to afford the title compound (1.24 g, 79%). MS (ESI) mass calcd. for C13H11FN2O2, 246.1. m/z found 247.0 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1228880-68-9, Methyl 3-bromo-5-methylpicolinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; Shireman, Brock T.; Lebold, Terry P.; Dvorak, Curt A.; Coate, Heather R.; Ziff, Jeannie M.; Preville, Cathy; Gelin, Christine; Chen, Gang; (123 pag.)US2016/75696; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1228880-68-9, Adding some certain compound to certain chemical reactions, such as: 1228880-68-9, name is Methyl 3-bromo-5-methylpicolinate,molecular formula is C8H8BrNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1228880-68-9.

a) 3-(2-Methoxycarbonyl-vinyl)-5-methyl-pyridine-2-carboxylic acid methyl ester 3-Bromo-5-methyl-pyridine-2-carboxylic acid methyl ester (1.6 g, 6.945 mmol), methylacrylate (1.50 g, 17.39 mmol), allylpalladium(II) chloride dimer (0.127 g, 0.348 mmol), tri-o-tolylphosphine (0.212 g, 0.695 mmol), water free sodium carbonate (2.211 g, 20.9 mmol), and N,N.dimethylacetamide (4.56 ml) were added to toluene (15 ml) and the reaction mixture was stirred for 18 h at 115 C. in a microwave apparatus. The mixture was diluted with EtOAc, washed with brine, dried over sodium sulfate, and the solvents were evaporated under reduced pressure. The residue was purified by chromatography on silica (Flashmaster, hex to hex/EtOAc 2/3 over 40 min, 20 min hex/EtOAc 2/3) to give the product as off-white solid (1.31 g, 80%). [1H-NMR (DMSO-d6, 600 MHz) delta 8.51 (s, 1H), 8.20 (s, 1H), 8.10 (d, 1H), 6.69 (d, 1H), 3.88 (s, 3H), 3.74 (s, 3H), 2.39 (s, 3H); LCMS RtL=2.753 min; [M+H]+=236.0]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1228880-68-9, Methyl 3-bromo-5-methylpicolinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; US2012/258973; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1228880-68-9, Methyl 3-bromo-5-methylpicolinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of Methyl 3-bromo-5-methylpicolinate, blongs to pyridine-derivatives compound. Quality Control of Methyl 3-bromo-5-methylpicolinate

j0352] To a sealed tube containing methyl 2-chloro-5-me- thylnicotinate (CAS 65 169-43-9) (745 g, 4.01 mmol), Cul (38 mg, 0.2 mmol), LiC1 (169 g, 4.01 mmol), and Pd(PPh3)4 (231 g, 0.2 mmol) in toluene (15 mE) was added 2-(tributyl- stannyl)pyrimidine (1.5 mE, 4.4 mmol), and the reaction mixture was heated at 120 C. overnight. The reaction mixture was diluted with water and extracted with DCM. The combined organic layers were dried over Mg504, filtered and evaporated. Purification via silica gel chromatography (0-50% EtOAc in hexanes) gave the title compound (494 g, 52%). Prepared analogous to intermediate A-66, step Asubstituting methyl 2-chloro-5-methylnicotinate with methyl3-bromo-5-methylpicolinate. MS (ESI) mass calcd. forC,2H,,N302, 229.1; mlz found 230.0 [M+H].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1228880-68-9, Methyl 3-bromo-5-methylpicolinate, and friends who are interested can also refer to it.

Reference:
Patent; Janssen Pharmaceutica NV; COATE, Heather R.; DVORAK, Curt A.; FITZGERALD, Anne E.; LEBOLD, Terry P.; PREVILLE, Cathy; SHIREMAN, Brock T.; (473 pag.)US2016/46640; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem