Category: 123-03-5

Matsuo, Kenya; Yoshihara, Kumiko; Nagaoka, Noriyuki; Makita, Yoji; Obika, Hideki; Okihara, Takumi; Matsukawa, Akihiro; Yoshida, Yasuhiro; Van Meerbeek, Bart published the artcile< Rechargeable anti-microbial adhesive formulation containing cetylpyridinium chloride montmorillonite>, Electric Literature of 123-03-5, the main research area is cetylpyridinium chloride montmorillonite antimicrobial adhesive formulation; Adhesive; Antibacterial; Cetylpyridinium chloride (CPC); Montmorillonite; Recharge; S. mutans.

Long-term anti-bacterial effect is a desired ability of any dental material in combating tooth caries as one of the most common and widespread persistent diseases today. Among several cationic quaternary ammonium compounds with antiseptic properties, cetylpyridinium chloride (CPC) is often used in mouthrinses and toothpastes. In this study, we incorporated CPC in a soft phyllosilicate mineral (clay), referred to as montmorillonite (Mont), to enable gradual CPC release with rechargeability. Besides measuring CPC release and recharge, we examined the anti-bacterial effect, cytotoxicity and bonding effectiveness of five exptl. adhesive formulations, prepared by adding 1 and 3 wt% CPC_Mont, 3 wt% Mont (without CPC), and 1 and 3 wt% CPC (without Mont) to the com. adhesive Clearfil S3 Bond ND Quick (C-S3B; Kuraray Noritake). Strong inhibition of Streptococcus mutans biofilm formation by CPC_Mont adhesives was confirmed by optical d. and SEM. CPC release from CPC_Mont adhesives was higher and lasted longer than from CPC adhesives, while CPC_Mont adhesives could also be recharged with CPC upon immersion in 2 wt% CPC. In conclusion, CPC_Mont technol. rendered adhesives anti-bacterial properties with recharge ability, this without reducing its bonding potential, neither increasing its cytotoxicity. Dental caries is one of the most prevalent chronic diseases in the population worldwide and is the major cause of tooth loss. In this study, we developed cetylpyridinium chloride (CPC) loaded montmorillonite (CPC-Mont) with a long-term antibacterial efficacy to prevent caries. CPC is an antibacterial agent approved by FDA, used as an OTC drug and contained in oral hygiene aids. CPC-Mont was incorporated in a dental adhesive to gradually release CPC. CPC_Mont technol. rendered adhesives anti-bacterial properties with rechargeability, this without reducing its bonding potential, neither increasing its cytotoxicity.

Acta Biomaterialia published new progress about Adhesives. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Electric Literature of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

de Assis, Ellen Lima; Silveira, Felipe Dantas; da Ponte, Alan Victor Araujo; Regis, Romulo Rocha published the artcile< A Systematic Review of the Potential Effects of Lippia sidoides on Dental Plaque and Periodontal Diseases>, Formula: C21H38ClN, the main research area is Lippia sidoides dental plaque periodontal disease potential effect.

Lippia sidoidesis a typical shrub from Brazil that has been used in traditional medicine. This is a systematic review on the effect of L. sidoidesfor controlling dental plaque, gingivitis, and periodontitis. A database search through May 2021 in Medline/PubMed, SCOPUS, BVS, and Web of Science identified 711 reports of which 17 met our inclusion criteria. Five randomized controlled trials and three animal studies were included that compared L. sidoides-based products (toothpaste, mouthrinse, and gel) to cetylpyridinium chloride, chlorhexidine, and placebo products. Among the human studies, a significant antiplaque effect after treatment with L. sidoides-based products was observed in three studies and an antigingivitis effect in two studies, similar to chlorhexidine-based products. One study found superior dental plaque reduction compared to cetylpyridinium chloride mouthrinse. Only one study testing a L. sidoidesgel found no antiplaque effect. Among the animal studies, an L. sidoidesmouthrinse significantly reduced calculus in two studies, inflammatory infiltrate in one study, and plaque bacteria and gingivitis in one study. An L. sidoidesgel significantly reduced alveolar bone loss and inflammatory response in one study in which mice were submitted to ligature-induced periodontal disease. In general, L. sidoides-based products were effective in reducing dental plaque and calculus formation, as well as clin. signs of gingivitis. As most studies present methodol. limitations, these results should be interpreted carefully. Further clin. trials with greater methodol. accuracy and control of biases are necessary for the use of L. sidoides-based products in humans to be viable in clin. practice.

Planta Medica published new progress about Alveolar bone. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Formula: C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cieplik, Fabian; Kara, Esra; Muehler, Denise; Enax, Joachim; Hiller, Karl-Anton; Maisch, Tim; Buchalla, Wolfgang published the artcile< Antimicrobial efficacy of alternative compounds for use in oral care toward biofilms from caries-associated bacteria in vitro>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is chlorhexidine digluconate streptococcus actinomyces biofilms propidium iodide polymicrobial; antimicrobial; biofilm; cetylpyridinium chloride; chlorhexidine; citrus extract; dental caries.

For caries-active patients, antimicrobial measures may be useful in addition to mech. biofilm removal. The aim of this study was to investigate the antimicrobial efficacy of alternative compounds for use in oral care from two main categories (i.e., preservatives and natural compounds) toward biofilms from caries-associated bacteria as compared to oral care gold-standards chlorhexidine digluconate (CHX), Streptococcus mutans (CPC), and zinc. Compounds were screened in initial Streptococcus mutans biofilms. Then, the most effective compounds were further investigated in mature S. mutans and polymicrobial biofilms comprising Actinomyces naeslundii,Actinomyces odontolyticus, and S. mutans. Biofilms were visualized by SEM and bacterial membrane damage was evaluated by means of flow cytometry and staining with SYBR Green and propidium iodide. Citrus extract was the only compound exhibiting similar antimicrobial efficacy in initial S. mutans biofilms (>5 log10) as compared to CHX and CPC, but its effect was clearly inferior in mature S. mutans and polymicrobial biofilms. From all alternative compounds investigated in this study, citrus extract exhibited the highest antimicrobial efficacy toward in vitro biofilms from caries-associated bacteria, but still was less effective than oral care gold-standard antiseptics CHX and CPC. Nevertheless, citrus extract may be a valuable antimicrobial compound for use in oral care for caries-active patients.

MicrobiologyOpen published new progress about Actinomyces naeslundii. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mao, Xiaojun; Auer, David L.; Buchalla, Wolfgang; Hiller, Karl-Anton; Maisch, Tim; Hellwig, Elmar; Al-Ahmad, Ali; Cieplik, Fabian published the artcile< Cetylpyridinium chloride: mechanism of action, antimicrobial efficacy in biofilms, and potential risks of resistance>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is review cetylpyridinium chloride antibacterial resistance biofilm biocide antiseptic; CPC; adaptation; antiseptic; biocide; cetylpyridinium chloride; oral; resistance.

A review. Antimicrobial resistance is a serious issue for public health care all over the world. While resistance toward antibiotics has attracted strong interest among researchers and the general public over the last 2 decades, the directly related problem of resistance toward antiseptics and biocides has been somewhat left untended. In the field of dentistry, antiseptics are routinely used in professional care, but they are also included in lots of oral care products such as mouthwashes or dentifrices, which are easily available for consumers over-the-counter. Despite this fact, there is little awareness among the dental community about potential risks of the widespread, unreflected, and potentially even needless use of antiseptics in oral care. Cetylpyridinium chloride (CPC), a quaternary ammonium compound, which was first described in 1939, is one of the most commonly used antiseptics in oral care products and included in a wide range of over-the-counter products such as mouthwashes and dentifrices. The aim of the present review is to summarize the current literature on CPC, particularly focusing on its mechanism of action, its antimicrobial efficacy toward biofilms, and on potential risks of resistance toward this antiseptic as well as underlying mechanisms. Furthermore, this work aims to raise awareness among the dental community about the risk of resistance toward antiseptics in general.

Antimicrobial Agents and Chemotherapy published new progress about Antibacterial agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kaur, Gurpreet; Garg, Preeti; Kaur, Baljinder; Chaudhary, Ganga Ram; Kumar, Sandeep; Dilbaghi, Neeraj; Hassan, P. A.; Aswal, V. K. published the artcile< Synthesis, thermal and surface activity of cationic single chain metal hybrid surfactants and their interaction with microbes and proteins>, Related Products of 123-03-5, the main research area is microbe protein metal hybrid surfactant cationic chain surface activity.

A series of water-soluble metal functionalized surfactants have been prepared using com. available surfactant cetyl pyridinium chloride and transition metal salts. These complexes were characterized in the solid state by elemental anal., FTIR, 1H NMR and thermogravimetric anal. The interfacial surface activity and aggregation behavior of the metallosurfactants were analyzed through conductivity, surface tension and small angle neutron scattering measurements. Our results show that the presence of metal ions as co-ions along with counter ions favors micellization at a low critical micellization concentration (CMC). Small angle neutron scattering revealed that the metallomicelles are of a prolate ellipsoidal shape and exhibit strong counterion binding. This article further describes the interaction of the metallosurfactants with transport protein Bovine Serum Albumin (BSA) using different spectroscopic techniques. A spectroscopic study was used to study the binding, interaction and quenching mechanism of BSA with the metallosurfactants. Gel electrophoresis (SDS-PAGE) and CD (CD) investigated the structural and conformational changes produced in BSA due to the metallosurfactants. The results indicate that there is an alteration in the secondary structure of BSA due to the electrostatic interaction between pos. head groups and metal co-ions of the metallosurfactants and neg. charged amino acids of BSA. As the concentration increases, the α-helicity of BSA decreases and all the three studied metallosurfactants gave comparable results. Finally, the in vitro cytotoxicity and antimicrobial activity of the metallosurfactants were evaluated against erythrocytes and microorganisms, which showed prominent effects related to the presence of a metal ion in metallomicelles of the hybrid surfactants.

Soft Matter published new progress about Antimicrobial agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Related Products of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ebrahimi, Ali; Schwartzman, Julia; Cordero, Otto X. published the artcile< Multicellular behaviour enables cooperation in microbial cell aggregates>, Name: 1-Hexadecylpyridin-1-ium chloride, the main research area is Vibrio multicellular behavior cell aggregation; alginate; microbial aggregate; self-organization; trait-based model.

Oligosaccharides produced from the extracellular hydrolysis of biol. materials can act as common goods that promote cooperative growth in microbial populations, whereby cell-cell aggregation increases both the per capita availability of resources and the per-cell growth rate. We built a computational model, which predicts cooperation is restricted in dense cell aggregates larger than 10μm because of the emergence of polymer and oligomer counter gradients. We compared these predictions to experiments performed with two well-studied alginate-degrading strains of Vibrio splendidus, which varied in their ability to secrete alginate lyase. We observed that both strains can form large aggregates (less than 50μm), overcoming diffusion limitation by rearranging their internal structure. The stronger enzyme producer grew non-cooperatively and formed aggregates with internal channels that allowed exchange between the bulk environment and the aggregate, whereas the weak enzyme producer showed strongly cooperative growth and formed dense aggregates in which cells near the core mixed by active swimming. Our simulations suggest that the mixing and channelling reduce diffusion limitation and allow cells to uniformly grow in aggregates. Together, these data demonstrate that bacterial behavior can help overcome competition imposed by resource gradients within cell aggregates. This article is part of a discussion meeting issue ‘Single cell ecol.’.

Philosophical Transactions of the Royal Society, B: Biological Sciences published new progress about Cell aggregation. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Name: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Salipante, Paul F.; Dharmaraj, Vishnu L.; Hudson, Steven D. published the artcile< Entrance effects and high shear rate rheology of shear-banding wormlike micelle fluids in a microcapillary flow>, Formula: C21H38ClN, the main research area is cetylpyridinium chloride sodium salicylate micelle fluid shear rate viscosity.

The viscosity of a shear-banding wormlike micelle solution at high shear rates is investigated by capillary rheol. and particle streak velocimetry. Measurements of the flow profile and pressure gradient show an extended entrance region, which exceeds a length to diameter ratio of 100, to reach a fully developed flow. We characterized this entrance region for capillaries with different cross sections and used the results to select a downstream portion of the capillary, where viscosity measurements can be made on fully developed flow. Measurements from this portion of the channel show a shear-thinning power-law behavior for all channel geometries from shear rates of 1000-120000s-1. Varying the surfactant concentration shows two distinct power-law behaviors that depend on both the shear rate and the concentration and are an indication of change in the micelle length. (c) 2020 American Institute of Physics.

Journal of Rheology (Melville, NY, United States) published new progress about Elasticity. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Formula: C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kang, Ji-Hoon published the artcile< Understanding inactivation of Listeria monocytogenes and Escherichia coli O157:H7 inoculated on romaine lettuce by emulsified thyme essential oil>, Product Details of C21H38ClN, the main research area is Listeria monocytogenes Escherichia coli romaine lettuce emulsified TEO; Cetylpyridinium chloride; Foodborne pathogen; Microbial adhesion; Romaine lettuce; Thyme essential oil emulsion; Washing effectiveness.

Effects of thyme essential oil (TEO) emulsion (TEE) with cationic charge formulated using cetylpyridinium chloride (CPC) on attachment strength and inactivation of Listeria monocytogenes and Escherichia coli O157:H7 on romaine lettuce surface were examined in this study. Regardless of the inoculation time (2 h and 24 h), pathogen attachment was stronger on the adaxial surface of the romaine lettuce than on the abaxial surface because of the lower roughness of the former. Moreover, attachment strength increased with increasing inoculation time. TEE washing had the strongest inhibitory effect on pathogen attachment at 2 h when compared with that of TEO, CPC, and sodium hypochlorite (SH), demonstrating a 3.32 and 2.53 log-reduction in the size of the L. monocytogenes and E. coli O157:H7 populations, resp., compared to the control samples. Addnl., the TEE washing effects were maintained even after inoculation for 24 h, and it decreased attachment to adaxial surface of the samples. These results indicate that TEE could be a good alternative to SH in improving the microbiol. safety of romaine lettuce.

Food Microbiology published new progress about Contact angle. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Product Details of C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem