Category: 123-03-5

Jeon, So Mi; Lim, Je Sun; Kim, Hyung-Ryong; Lee, Jong-Ho published the artcile< PFK activation is essential for the odontogenic differentiation of human dental pulp stem cells>, Electric Literature of 123-03-5, the main research area is human dental pulp stem cell odontogenic differentiation PFK activation; Aerobic glycolysis; Differentiation; Human dental pulp stem cell; Odontoblast; PFK.

Dental pulp stem cells (DPSCs) can differentiate into diverse cell lineages, including odontogenic cells that are responsible for dentin formation, which is important in pulp repair and tooth regeneration. While glycolysis plays a central role in various cellular activities in both physiol. and pathol. conditions, its role and regulation in odontogenic differentiation are unknown. Here, we show that aerobic glycolysis is induced during odontoblastic differentiation from human DPSCs. Importantly, we demonstrate that during odontoblastic differentiation, protein expression levels of phosphofructokinase 1 muscle isoform (PFKM) and PFK2, but not other glycolytic enzymes, are mainly upregulated by AKT activation, resulting in increased total PFK enzyme activity. Increased PFK activity is essential to enhance aerobic glycolysis, which plays an important role in the odontoblastic differentiation of human DPSCs. These findings underscore that PFK activation-induced aerobic glycolysis accompanies, and participates in, human DPSCs differentiation into odontogenic lineage, and could play a role in the regulation of dental pulp repair.

Biochemical and Biophysical Research Communications published new progress about Dental pulp. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Electric Literature of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Alvarez, Diana M.; Duarte, Luisa F.; Corrales, Nicolas; Smith, Patricio C.; Gonzalez, Pablo A. published the artcile< Cetylpyridinium chloride blocks herpes simplex virus replication in gingival fibroblasts>, Reference of 123-03-5, the main research area is cetylpyridinium chloride antiviral gingival fibroblast herpes simplex virus infection; Antiviral; Cetylpyridinium chloride, CPC; Fibroblasts; Herpes simplex viruses; NF-κB.

Infections with herpes simplex viruses are lifelong and highly prevalent worldwide. Individuals with clin. symptoms elicited by HSVs may suffer from occasional or recurrent herpetic lesions in the orofacial and genital areas. Despite the existence of nucleoside analogs that interfere with HSV replication, such as acyclovir, these drugs are somewhat ineffective in treating skin lesions as topical formulations only reduce in one or few days the duration of the herpetic ulcers. Cetylpyridinium chloride (CPC) is a quaternary ammonium compound present in numerous hygiene products, such as mouthwashes, deodorants, aphtae-treating formulations and oral tablets as an anti-septic to limit bacterial growth. Some reports indicate that CPC can also modulate host signaling pathways, namely NF-κB signaling. Because HSV infection is modulated by NF-κB, we sought to assess whether CPC has antiviral effects against HSVs. Using wild-type HSV-1 and HSV-2, as well as viruses that are acyclovir-resistant or encode GFP reporter genes, we assessed the antiviral capacity of CPC in epithelial cells and human gingival fibroblasts expanded from the oral cavity and its mechanism of action. We found that a short, 10-min exposure to CPC added after HSV entry into the cells, significantly limited viral replication in both cell types by impairing viral gene expression. Interestingly, our results suggest that CPC blocks HSV replication by interfering with the translocation of NF-κB into the nucleus of HSV-infected cells. Taken together, these findings suggest that formulations containing CPC may help limit HSV replication in infected tissues and consequently reduce viral shedding.

Antiviral Research published new progress about Antiviral agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Reference of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Frolov, Nikita; Detusheva, Elena; Fursova, Nadezhda; Ostashevskaya, Irina; Vereshchagin, Anatoly published the artcile< Microbiological Evaluation of Novel Bis-Quaternary Ammonium Compounds: Clinical Strains, Biofilms, and Resistance Study>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is clin strains biofilms microbiologica novel bis quaternary ammonium compound; antibacterial activity; antibiofilm activity; antiseptics; bacterial resistance; biocides; disinfectants; pyridinium salts; quaternary ammonium compounds.

This work is devoted to the investigation of biocidal properties of quaternary ammonium compounds (QACs) based on pyridine structures with aromatic spacers, and their widely known analogs, against clin. significant microorganisms. This study is focused on investigating their antimicrobial activity (min. inhibitory concentrations (MICs) and min. bactericidal concentrations (MBCs)), antibiofilm properties (min. biofilm inhibitory concentrations (MBICs) and min. biofilm eradication concentrations (MBECs)), synergetic effect with different alcs. in antiseptic formulations, and bacterial resistance development. It was shown that all combined analog preparations had a higher level of antibacterial activity against the tested bacterial strains, with a 16- to 32-fold reduction in MICs and MBCs compared to previously used antiseptic preparations Moreover, hit-QACs demonstrated a stable effect against Gram-neg. E. coli, K. pneumoniae, and A. baumannii within a month of incubation. Overall results indicated a high level of antibacterial activity of pyridine-based QACs.

Pharmaceuticals published new progress about Acinetobacter baumannii. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mhanna, Ramona; Lee, Jonghun; Narayanan, Suresh; Reich, Daniel H.; Leheny, Robert L. published the artcile< Phase-dependent shear-induced order of nanorods in isotropic and nematic wormlike micelle solutions>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is gold nanorod hexagonal wormlike micelle solution.

Small angle X-ray scattering with in situ shear was employed to study the assembly and ordering of dispersions of gold nanorods within wormlike micelle solutions formed by the surfactant cetylpyridinium chloride (CPyCl) and counter-ion sodium salicylate (NaSal). Above a threshold CPyCl concentration but below the isotropic-to-nematic transition of the micelles, the nanorods self-assembled under quiescent conditions into isotropically oriented domains with hexagonal order. Under steady shear at rates between 0.5 and 7.5 s-1, the nanorod assemblies acquired macroscopic orientational order in which the hexagonal planes were coincident with the flow-vorticity plane. The nanorods could be re-dispersed by strong shear but re-assembled following cessation of the shear. In the nematic phase of the micelles at higher surfactant concentration, the nanorods did not acquire hexagonal order but instead formed smectic-like layers in the gradient-vorticity plane under shear. Finally, at still higher surfactant concentration, where the micelles form a hexagonal phase, the nanorods showed no translational ordering but did acquire nematic-like order under shear due to alignment in the flow. Depletion forces mediated by the wormlike micelles are identified as the driving mechanism for this sequence of nanorod ordering behaviors, suggesting a novel mechanism for controlled, reconfigurable assembly of nanoparticles in solution

Nanoscale published new progress about Aggregation. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fizer, Oksana; Fizer, Maksym; Sidey, Vasyl; Studenyak, Yaroslav published the artcile< Predicting the end point potential break values: A case of potentiometric titration of lipophilic anions with cetylpyridinium chloride>, Category: pyridine-derivatives, the main research area is Predicting end point potential break values potentiometric titration.

The applicability of cetylpyridinium chloride for potentiometric titration of lipophilic anions has been studied. The specially developed cetylpyridinium-selective plasticized electrode has been used for the investigation of the mechanism of interaction between the cetylpyridinium cation and lipophilic anions, which obviously goes through the association reaction resulting in the formation of water-insoluble precipitates The investigated 54 anions were placed in the selectivity row that strongly correlates with lipophilicity. Addnl., an attempt has been made to find a simple and reliable descriptor suitable for prediction of the value of the end point potential break and thus indicating the applicability of the described potentiometric method for determination of untested lipophilic anions of interest. It has been established that despite being well known lipophilicity estimators, molar weight, octanol-water distribution coefficient logP, logarithm of solubility logS, and hydrophilicity-lipophilicity index can not be sep. used for directly predicting the end point potential break values. However, simultaneous anal. of the above descriptors by using the multiple linear regression technique has resulted in the development of a reasonable QSPR model for the estimation of the potential break values near the end point.

Microchemical Journal published new progress about Chemical potential. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guo, Wenjing; Fu, Zhiyou; Zhang, Zhiyong; Wang, Hao; Liu, Shasha; Feng, Weiying; Zhao, Xiaoli; Giesy, John P. published the artcile< Synthesis of Fe3O4 magnetic nanoparticles coated with cationic surfactants and applications in Sb(V) removal from water>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is synthesis Fe3O4 magnetic nanoparticle coated cationic surfactant Sb removal; Adsorption; Fe(3)O(4); Magnetic nanoparticle; Sb(V); Surfactant.

Antimony (Sb) pollution was an emerging environmental risk in several contaminated waters, whereas its removal still presented as a severe challenge due to the lack of efficient adsorbent and its further removal mechanism. In this study, synthesized absorbents, Fe3O4 magnetic nanoparticles (Fe-MNPs) modified and dispersed with commonly used cationic surfactants, were applied to remove Sb contamination in real surface waters, its synthesized conditions, removal performance and mechanism were investigated by using batch experiments and characterization analyses. Optimum conditions on Sb(V) (the dominant form is Sb(OH)-6) removal by modified adsorbents were obtained as: cetylpyridinium chloride (CPC) coated on Fe-MNPs, mass ratio of Fe-MNPs: CPC = 4:1 and pH = 3-5. Magnetic properties of synthesized adsorbent were not affected, dispersibility was enhanced after fabrication of CPC, that indicated the Fe-MNPs@CPC could be separated and reused with external magnetic field. The adsorption efficiency of this low-cost adsorbent coated with CPC was superior than several traditional adsorbents. The practical application of Fe-MNPs@CPC in five types real waters from the Xikuangshan (XKS) Sb mine area and regeneration experiments by 1 M (mol/L) NaOH solution further confirm its practicability and reusability. Removal experiment results, XPS and Fourier transform IR spectroscopy (FT-IR) spectra suggested that electrostatic attraction and surface bonding might responsible for the Sb(V) removal by Fe-MNPs modified with cationic surfactants.

Science of the Total Environment published new progress about Adsorbents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shirani, Farzaneh; Mazdak, Ali; Mazaheri, Peiman; Shirani, Mehrangiz; Samimi, Pouran published the artcile< Evaluation of the effect of anti-COVID-19 mouthwashes on shear bond strength of composite resin restorations to dentin and enamel: an ""in vitro study"">, Name: 1-Hexadecylpyridin-1-ium chloride, the main research area is dentin enamel shear bond strength mouthwash coronavirus disease 2019.

Given the high prevalence of the coronavirus and the high risk of virus transfer to dentists, the use of mouthwashes, which can potentially eliminate this virus, is suggested before dental procedures. Since these mouthwashes may affect the bond strength of composite resin restorations to teeth, this study was conducted to investigate the effect of recommended mouthwashes on the shear bond strength of composite resin restorations to dentin and enamel in selective etch and rinse and two-step self-etch bonding systems. Five groups of posterior teeth (n = 15) were selected for five groups of cetylpyridinium chloride 0.07%, povidone-iodine 1%, hydrogen peroxide 1%, and chlorhexidine 0.2% as mouthwash and distilled water as the control group. The buccal enamel and lingual dentin of each tooth were rinsed after immersion in a mouthwash. After 20 s of enamel acid-etching and 15 s of dentin priming, they were impregnated with an adhesive, and composite cylinders were placed on the dentin and enamel surfaces of the tooth. The shear bond strength test was performed after 24 h, and results were analyzed by ANOVA and paired t-test (α = 0.05). The mean shear bond strength of enamel to composite was significantly (p = 0.05) higher than that of dentin to composite in each study group, but no significant difference was found between the mean shear bond strength of composite to enamel (p = 0.199) and to dentin (p = 0.335) after the use of mouthwashes and that of the control group. The use of mouthwashes used in this study did not have neg. effects on the shear bond strength of composite to enamel and dentin.

BioMed Research International published new progress about Bond energy (shear). 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Name: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pal, Amalendu; Punia, Renu published the artcile< Mixed micellization behaviour of tri-substituted surface active ionic liquid and cationic surfactant in aqueous medium and salt solution: Experimental and theoretical study>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is tetradecyldimethylimidazolium cetyltrimethylammonium sodium bromide aqueous medium micellization physiochem property.

The aim of the present study is to investigate the mixed micellization behavior of trisubstituted surface active ionic liquid (SAIL) 1-tetradecyl-2,3-dimethylimidazolium bromide and cationic surfactant CTAB in aqueous solution and in the presence of inorganic salt, NaBr using the conductivity, steady-state fluorescence and 1H NMR measurements. The degree of counter-ion dissociation (g), critical micelle concentration (cmc), various thermodn. parameters of micellization (ΔG0m, ΔH0m and ΔS0m) have been evaluated from conductivity measurements. The aggregation number (Nagg) of mixed micelle has been ascertained from steady-state fluorescence quenching indicate that the contribution of CTAB was always more than that of SAIL. Various mixed micellar parameters such as ideal cmc (cmc*), activity coefficients (f1 and f2), micellar mole fraction of CTAB in mixed and ideal state (Xm1andXideal1), interaction parameter (βm) and excess Gibbs free energy of micellization (ΔGex) have been calculated at temperatures of (298.15, 308.15 and 318.15) K. Mixed micellar parameters (cmc*, Xm1, and ΔGex) reveal non-ideal behavior of the mixed system and magnitude of interaction parameter (βm) becomes more neg. in the presence of salt. 1H NMR shed light on the electrostatic interactions between CTAB and SAIL in mixed state.

Journal of Molecular Liquids published new progress about Electric conductivity. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Ying; Du, Na; Song, Shue; Hou, Wanguo published the artcile< Adsorption of Cetylpyridinium Chloride at Silica Nanoparticle/Water Interfaces (I): Dependence of Adsorption Equilibrium on Particle Size>, SDS of cas: 123-03-5, the main research area is adsorption cetylpyridinium chloride silica nanoparticle size water interface equilibrium.

In the current work, a size-effect model was developed to describe the particle size-dependence of adsorption at solid/liquid interfaces. A parameter, ΔQad, was introduced, defined as the change of the product of the solid/liquid interfacial tension and the molar volume of solid surface components caused by adsorption. The model predicts that with a decrease in particle radius (r), the saturation adsorption amount per unit area (Γm, mol/m2) decreases, while the change of the adsorption equilibrium constant (Kad) is determined by the ΔQad, namely, it decreases if ΔQad > 0 but increases if ΔQad < 0. There exists a critical r at which the saturation adsorption amount per unit mass (Γmg, mol/g) attains a maximum In addition, the adsorption of cetylpyridinium chloride (CPyCl), a cationic surfactant, on silica nanoparticles with different r (ca. 6-61 nm) values was determined at 298 K and pH 9, showing an obvious size-dependence. With a decrease in r, Kad and Γm decrease, indicating a decrease in the affinity of silica particles toward CPyCl. The size-dependent adsorption data can be well described using our model. Adsorption can affect the molar volume of the solid surface phase, which plays an important role in the size-dependence of adsorption. This work provides a better understanding of the size-dependent adsorption phenomenon at solid/liquid interfaces. Langmuir published new progress about Adsorption. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, SDS of cas: 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Munoz-Basagoiti, J.; Perez-Zsolt, D.; Leon, R.; Blanc, V.; Raich-Regue, D.; Cano-Sarabia, M.; Trinite, B.; Pradenas, E.; Blanco, J.; Gispert, J.; Clotet, B.; Izquierdo-Useros, N. published the artcile< Mouthwashes with CPC Reduce the Infectivity of SARS-CoV-2 Variants In Vitro>, Formula: C21H38ClN, the main research area is cetylpyridinium chloride mouthwash virucide COVID19; COVID-19; airborne transmission; cellular infection; coronaviruses; oral hygiene; virucide.

Oral mouthwashes decrease the infectivity of several respiratory viruses including SARS-CoV-2. However, the precise agents with antiviral activity in these oral rinses and their exact mechanism of action remain unknown. Here we show that cetylpyridinium chloride (CPC), a quaternary ammonium compound in many oral mouthwashes, reduces SARS-CoV-2 infectivity by inhibiting the viral fusion step with target cells after disrupting the integrity of the viral envelope. We also found that CPC-containing mouth rinses decreased more than a thousand times the infectivity of SARS-CoV-2 in vitro, while the corresponding vehicles had no effect. This activity was effective for different SARS-CoV-2 variants, including the B.1.1.7 or Alpha variant originally identified in United Kingdom, and in the presence of sterilized saliva. CPC-containing mouth rinses could therefore represent a cost-effective measure to reduce SARS-CoV-2 infectivity in saliva, aiding to reduce viral transmission from infected individuals regardless of the variants they are infected with.

Journal of Dental Research published new progress about Antiviral agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Formula: C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem