Category: 123-03-5

Saud, Zack; Tyrrell, Victoria J.; Zaragkoulias, Andreas; Protty, Majd B.; Statkute, Evelina; Rubina, Anzelika; Bentley, Kirsten; White, Daniel A.; Rodrigues, Patricia Dos Santos; Murphy, Robert C.; Kofeler, Harald; Griffiths, William J.; Alvarez-Jarreta, Jorge; Brown, Richard William; Newcombe, Robert G.; Heyman, James; Pritchard, Manon; Mcleod, Robert WJ.; Arya, Arvind; Lynch, Ceri-Ann; Owens, David; Jenkins, P. Vince; Buurma, Niklaas J.; O’Donnell, Valerie B.; Thomas, David W.; Stanton, Richard J. published the artcile< The SARS-CoV2 envelope differs from host cells, exposes procoagulant lipids, and is disrupted in vivo by oral rinses>, Related Products of 123-03-5, the main research area is lipidome cetylpyridinium chloride oral rinse phospholipid SARSCoV2 envelope; CPC; aminophospholipids; cetylpyridinium chloride; clinical trials; coagulation; inflammation; lipidomics; mouthwash; phospholipids; virology.

The lipid envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an essential component of the virus; however, its mol. composition is undetermined Addressing this knowledge gap could support the design of antiviral agents as well as further our understanding of viral-host protein interactions, infectivity, pathogenicity, and innate immune system clearance. Lipidomics revealed that the virus envelope comprised mainly phospholipids (PLs), with little cholesterol or sphingolipids, indicating significant differences from host membranes. Unlike cellular membranes, procoagulant amino-PLs were present on the external side of the viral envelope at levels exceeding those on activated platelets. Accordingly, virions directly promoted blood coagulation. To investigate whether these differences could enable selective targeting of the viral envelope in vivo, we tested whether oral rinses containing lipid-disrupting chems. could reduce infectivity. Products containing PL-disrupting surfactants (such as cetylpyridinium chloride) met European virucidal standards in vitro; however, components that altered the critical micelle concentration reduced efficacy, and products containing essential oils, povidone-iodine, or chlorhexidine were ineffective. This result was recapitulated in vivo, where a 30-s oral rinse with cetylpyridinium chloride mouthwash eliminated live virus in the oral cavity of patients with coronavirus disease 19 for at least 1 h, whereas povidone-iodine and saline mouthwashes were ineffective. We conclude that the SARS-CoV-2 lipid envelope (i) is distinct from the host plasma membrane, which may enable design of selective antiviral approaches; (ii) contains exposed phosphatidylethanolamine and phosphatidylserine, which may influence thrombosis, pathogenicity, and inflammation; and (iii) can be selectively targeted in vivo by specific oral rinses.

Journal of Lipid Research published new progress about Antiviral agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Related Products of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rajendiran, Meenakshi; Trivedi, Harsh M.; Chen, Dandan; Gajendrareddy, Praveen; Chen, Lin published the artcile< Recent development of active ingredients in mouthwashes and toothpastes for periodontal diseases>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is review cetylpyridinium chloride mouthwash toothpaste periodontal disease; active ingredients; gingivitis; mouthwashes; periodontal diseases; periodontitis; plaque; toothpastes.

A review. Periodontal diseases like gingivitis and periodontitis are primarily caused by dental plaque. Several antiplaque and anti-microbial agents have been successfully incorporated into toothpastes and mouthwashes to control plaque biofilms and to prevent and treat gingivitis and periodontitis. The aim of this article was to review recent developments in the antiplaque, anti-gingivitis, and anti-periodontitis properties of some common compounds in toothpastes and mouthwashes by evaluating basic and clin. studies, especially the ones published in the past five years. The common active ingredients in toothpastes and mouthwashes included in this review are chlorhexidine, cetylpyridinium chloride, sodium fluoride, stannous fluoride, stannous chloride, zinc oxide, zinc chloride, and two herbs-licorice and curcumin. We believe this comprehensive review will provide useful up-to-date information for dental care professionals and the general public regarding the major oral care products on the market that are in daily use.

Molecules published new progress about Formulation active agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dong, Dong; Thomas, Nicky; Ramezanpour, Mahnaz; Psaltis, Alkis J.; Huang, Shuman; Zhao, Yulin; Thierry, Benjamin; Wormald, Peter-John; Prestidge, Clive A.; Vreugde, Sarah published the artcile< Inhibition of Staphylococcus aureus and Pseudomonas aeruginosa biofilms by quatsomes in low concentrations>, Name: 1-Hexadecylpyridin-1-ium chloride, the main research area is Staphylococcus Pseudomonas biofilm quatsome; CPC-quatsome; Chronic rhinosinusitis; Pseudomonas aeruginosa; Staphylococcus aureus; biofilm; cetylpyridinium chloride.

This study investigated the inhibition effect of cetylpyridinium chloride (CPC)-quatsomes at low concentrations on both S. aureus and P. aeruginosa biofilms in vitro, as well as their toxicities towards cultured human airway epithelial (NuLi-1) cells. CPC-quatsome and CPC micelle solutions at concentrations of 0.01%, 0.025%, and 0.05% were prepared Confocal laser scanning microscopy (CLSM) was used to investigate the interactions between CPC-quatsomes and S. aureus and P. aeruginosa biofilms. A lactate dehydrogenase (LDH) assay was used to determine the toxicity of CPC-quatsomes on NuLi-1 cells. CPC-quatsome and CPC micelle solutions had significant inhibition effects at all tested concentrations on planktonic S. aureus and P. aeruginosa and their biofilms. In the CLSM study, different interactions between CPC-quatsomes and S. aureus or P. aeruginosa biofilms were observed CPC-quatsomes at low concentrations inhibited S. aureus and P. aeruginosa in both planktonic form and biofilms. No adverse effects on NuLi-1 cells were observed, indicating their promising potential in the treatment of CRS. In our study, CPC-quatsomes at concentrations of 0.01%, 0.025%, and 0.05% had significant inhibition effects on both planktonic and biofilms of S. aureus and P. aeruginosa. The result of this study indicates the promising potential of CPC-quatsome in the treatment of CRS.

Experimental Biology and Medicine (London, United Kingdom) published new progress about Biofilms (microbial). 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Name: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Jianxiong; Du, Guo; Xie, Lei; Yuan, Kai; Zhu, Yirong; Xu, Lijian; Li, Na; Wang, Xianyou published the artcile< Three-Dimensional Walnut-Like, Hierarchically Nanoporous Carbon Microspheres: One-Pot Synthesis, Activation, and Supercapacitive Performance>, Electric Literature of 123-03-5, the main research area is supercapacitor hierarchically nanoporous carbon template walnut like activation.

A one-pot synthesis of three-dimensional walnut-like, hierarchically nanoporous carbon microspheres (HNCMs) via a dual-template method was reported. In our protocol, the organic mesomorphous complexes of hexadecylpyridinium chloride/poly(acrylic acid) (CPC/PAA) were employed as a dynamic soft template; the in situ generated silica during the hydrolysis of tetraethylsiloxane (TEOS) was applied as the hard template and sucrose, as the carbon precursor. When the amount of PAA added was varied, hierarchically nanoporous carbons with other novel morphologies such as having a hexagonal nanoplate, being dumbbell-like, and having a hexagonal microprism were synthesized in a controlled manner. Besides, the pore structure of HNCMs was tailored by tuning the molar ratio of sucrose and TEOS. It was demonstrated that the specific capacitance of the HNCMs was correlated with the orderliness of the mesopores. HNCMs-15 synthesized under the molar ratio of sucrose/TEOS at 15 with well-ordered mesopores exhibited the highest specific capacitance of 232 F g-1 at 1 A g-1. The as-prepared HNCMs-15 was further chem. activated, which resulted in the activated HNCMs-15 (AHNCMs-15) with no obvious morphol. change but a high proportion of micropores, large surface area, and superior electrochem. properties (high specific capacitance of 413 F g-1 at 1 A g-1, excellent rate capability). The AHNCMs-15-based sym. supercapacitor displayed a high energy d. of 14.7 Wh kg-1 at a power d. of 250 W kg-1 and small capacitance fading (only 1.6%) after 10 000 cycles at 2 A g-1. Our strategy provides a way for the controlled synthesis of hierarchically nanoporous carbon with well-defined morphol. and structure and excellent electrochem. properties, which makes them promising electrode materials for high-performance supercapacitors. A one-pot synthesis of three-dimensional walnut-like, hierarchically nanoporous carbon microspheres for high-performance sustainable electrochem. energy device, was reported.

ACS Sustainable Chemistry & Engineering published new progress about Carbonization. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Electric Literature of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lennon, Kyle R.; Geri, Michela; McKinley, Gareth H.; Swan, James W. published the artcile< Medium amplitude parallel superposition (MAPS) rheology. Part 2: Experimental protocols and data analysis>, Computed Properties of 123-03-5, the main research area is medium amplitude parallel superposition rheol.

An exptl. protocol is developed to directly measure the new material functions revealed by medium amplitude parallel superposition (MAPS) rheol. This protocol measures the medium amplitude response of a material to a simple shear deformation composed of three sine waves at different frequencies, revealing a rich dataset consisting of up to 19 measurements of the third-order complex modulus at distinct three-frequency coordinates. We discuss how the choice of input frequencies influences the features of the MAPS domain studied by the experiment A polynomial interpolation method for reducing the bias of measured values from spectral leakage and reducing variance due to noise is discussed, including a derivation of the optimal range of amplitudes for the input signal. This leads to the conclusion that conducting the experiment in a stress-controlled fashion possesses a distinct advantage to the strain-controlled mode. The exptl. protocol is demonstrated through measurements of the MAPS response of a model complex fluid: a surfactant solution of wormlike micelles. The resulting dataset is indeed large and feature-rich, while still acquired in a time comparable to similar medium amplitude oscillatory shear (MAOS) experiments We demonstrate that the data represent measurements of an intrinsic material function by studying its internal consistency, compatibility with low-frequency predictions for Coleman-Noll simple fluids, and agreement with data obtained via MAOS amplitude sweeps. Finally, the data are compared to predictions from the corotational Maxwell model to demonstrate the power of MAPS rheol. in determining whether a constitutive model is consistent with a material’s time-dependent response. (c) 2020 American Institute of Physics.

Journal of Rheology (Melville, NY, United States) published new progress about Computer program. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Computed Properties of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zayed, Naiera; Boon, Nico; Bernaerts, Kristel; Chatzigiannidou, Ioanna; Van Holm, Wannes; Verspecht, Tim; Teughels, Wim published the artcile< Differences in chlorhexidine mouthrinses formulations influence the quantitative and qualitative changes in in-vitro oral biofilms>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is antimicrobial chlorhexidine mouthrinse oral biofilm; antimicrobials; chlorhexidine; mouthrinses; oral biofilms.

Chlorhexidine mouthrinses are marketed in different formulations. This study aimed at investigating qual. and quant. changes in in-vitro multispecies oral biofilms, induced by different chlorhexidine-containing mouthrinses. Earlier studies comparing chlorhexidine mouthrinses are either clin. studies or in-vitro studies assessing the antimicrobial efficacy of the mouthrinses. However, no clear investigations are available regarding ecol. impact of different chlorhexidine formulations on in-vitro multispecies oral biofilms after rinsing with different chlorhexidine formulations. Nine com. available chlorhexidine mouthrinses were selected. Multispecies oral communities (14 species) were grown for 48 h in a Biostat-B Twin bioreactor. After that, they were used to develop biofilms on the surface of hydroxyapatite disks in 24-well pates for 48 h. Biofilms were then rinsed once or multiple times with the corresponding mouthrinse. Biofilms were collected before starting the rinsing experiment and every 24 h for 3 days and vitality quant. PCR was performed. The experiment was repeated 3 independent times on 3 different days and the results were analyzed using a linear mixed model. The mouthrinses provoked different effects in terms of change in total viable bacterial load (VBL), ecol., and community structure of the multispecies biofilms. There was no relation between chlorhexidine concentrations, presence, or absence of cetylpyridinium chloride and/or alc., and the observed effects. Some tested chlorhexidine mouthrinses (MC, HG, HH, and HI) strongly lowered the total VBL (≈1007 Geq/mL), but disrupted biofilm symbiosis (≥40% of the biofilms communities are pathobionts). On the other hand, other tested chlorhexidine mouthrinses (MD, ME, and HF) had limited impact on total VBL (≥ 1010 Geq/mL), but improved the biofilm ecol. and community structure (≤ 10% of the biofilms communities are pathobionts). Not all chlorhexidine mouthrinses have the same effect on oral biofilms. Their effect seems to be strongly product dependent and vary according to their compositions and formulations.

Journal of Periodontal Research published new progress about Antimicrobial agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Shengrong; Chen, Ming; Cao, Xiaoqiang; Li, Guang; Zhang, Di; Li, Mingzhen; Meng, Na; Yin, Jieji; Yan, Bingqi published the artcile< Chromium (VI) removal from water using cetylpyridinium chloride (CPC)-modified montmorillonite>, Reference of 123-03-5, the main research area is chromium removal water cetylpyridinium chloride modified montmorillonite.

Montmorillonite (Mt) has been used widely for metal removal from water and wastewater due to its various advantages including low cost, large surface area, high structure stability, and high ion exchange capacity. However, the removal of anionic hexavalent chromium (Cr) using Mt is inhibited by the neg. charges on the adsorbent. To enhance Cr (VI) adsorption on Mt, a cationic surfactant – cetylpyridinium chloride (CPC) – was utilized to modify the interlayer surface of Mt. Fourier-transform IR spectroscopy and X-ray diffraction were performed to characterize the CPC modified Mt (CPC-Mt) and the structure change of Mt. Studies have shown that CPC intercalated into Mt interlayers via electrostatic interaction between Mt and CPC, as well as the hydrophobic interaction among CPC mols. After modification, the CPC-Mt showed a pos. zeta potential at pH 2-11; while the sp. surface area decreased, CPC effectively increased the interlayer distance of Ca-Mt, with a maximum d001 value of 4.37 nm, and provided more exchange sites for Cr (VI) adsorption. Cr (VI) was efficiently removed using CPC-Mt at low pH values, but the removal was influenced adversely by the increase of pH and ionic strength. The adsorption process was described by a Langmuir isotherm model with the constant of 0.342 L/mg and the maximum adsorption capacity of 43.84 mg/g at 298 K, and by a pseudo-second order kinetic model with a kinetic coefficient of 6.62 g/(mg·min). The adsorption mechanism anal. has shown that electrostatic attraction is the main mechanism for Cr (VI) removal; at the same time, the reduction of Cr (VI) to Cr (III) by Fe (II) in Mt cannot be neglected at low pH values, which increased Cr removal and was confirmed by the X-ray photoelectron spectroscopic anal.

Separation and Purification Technology published new progress about Adsorbents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Reference of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

He, Qiao; Guo, Mingming; Jin, Tony Z.; Arabi, Saifanassour Ali; Liu, Donghong published the artcile< Ultrasound improves the decontamination effect of thyme essential oil nanoemulsions against Escherichia coli O157: H7 on cherry tomatoes>, Electric Literature of 123-03-5, the main research area is cherry tomato Escherichia coli thyme essential oil nanoemulsion decontamination; Antibacterial activity; Cherry tomato; E. coli O157:H7; Thyme essential oil nanoemulsion; Ultrasound.

Development of novel and effective decontamination technologies to ensure the microbiol. safety of fresh produce has gained considerable attention, mainly driven by numerous outbreaks. This work presented the first approach regarding to the application of the previously reported hurdle technologies on the sanitization of artificially contaminated cherry tomatoes. Thyme (Thymus daenensis) essential oil nanoemulsion (TEON, 8.28 nm in diameter with a narrow size distribution) was formulated via ultrasonic nanoemulsification, showing remarkably improved antimicrobial activity against Escherichia coli (E. coli) O157:H7, compared to the coarse emulsion. The antimicrobial effect of ultrasound (US), thyme essential oil nanoemulsion (TEON) and the combination of both treatments was assessed against E. coli O157:H7. The remarkable synergistic effects of the combined treatments were achieved, which decontaminated the E. coli populations by 4.49-6.72 log CFU/g on the surface of cherry tomatoes, and led to a reduction of 4.48-6.94 log CFU/sample of the total inactivation. TEON combined with US were effective in reducing the presence of bacteria in wastewater, which averted the potential detrimental effect of cross-contamination resulted from washing wastewater in fresh produce industry. Moreover, the treatments did not noticeably alter the surface color and firmness of cherry tomatoes. Therefore, ultrasound combined with TEON is a promising and feasible alternative for the reduction of microbiol. contaminants, as well as retaining the quality characteristics of cherry tomatoes.

International Journal of Food Microbiology published new progress about Antimicrobial agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Electric Literature of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sun, Yi; Hu, Xueyan; Guo, Du; Shi, Chao; Zhang, Chunling; Peng, Xiaoli; Yang, Hua; Xia, Xiaodong published the artcile< Disinfectant Resistance Profiles and Biofilm Formation Capacity of Escherichia coli Isolated from Retail Chicken>, Formula: C21H38ClN, the main research area is resistance biofilm formation Escherichia chicken; biofilm formation capacity; disinfectant resistance; disinfectant-resistant genes.

Disinfectant resistance and biofilm formation capacity are two important characteristics that contribute to the persistence of microorganisms in food processing environments and contamination of food products. This study investigated the susceptibility of 510 Escherichia coli isolates against 5 disinfectants and the prevalence of 10 disinfectant-resistant genes in these isolates. The biofilm formation capacity of 194 isolates was determined, and the correlation between disinfectant resistance and biofilm formation was analyzed. The minimal inhibitory concentrations (MICs) of cetyltrimethylammonium bromide (CTAB), benzalkonium chloride (BC), cetylpyridinium chloride, and chlorhexidine (CHX) against isolates were 32-512, 16-256, 32-256, and 2-32 mg/L, resp. The MICs of triclosan against 88.43% of isolates were 8-1,024 mg/L, while the MICs for the rest of isolates exceed 2,048 mg/L. The presence of ydgE, ydgF, and qacF genes was significantly correlated with the CHX resistance of E. coli isolates, while the presence of qacF and qacEΔ1 genes was significantly correlated with CTAB and BC resistance, resp. The biofilm formation capacity (adjusted optical d. value) was pos. correlated with BC resistance (r = 0.201, p < 0.01) and showed no correlation with other disinfectants. The presence of sugE(p) was pos. correlated with biofilm formation, while four genes were neg. correlated with biofilm formation. This study provides useful data on disinfectant resistance and biofilm formation capacity of E. coli contaminating poultry products, which could be helpful in guiding proper disinfectant usage and establishing effective biofilm eradication strategy in food industry. Microbial Drug Resistance (New Rochelle, NY, United States) published new progress about Biofilms (microbial). 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Formula: C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Omidvar, Rose; Wu, Shijian; Mohammadigoushki, Hadi published the artcile< Detecting wormlike micellar microstructure using extensional rheology>, Name: 1-Hexadecylpyridin-1-ium chloride, the main research area is wormlike micellar microstructure rheol.

We report experiments on two series of wormlike micellar solutions that comprise octyl trimethylammonium bromide/sodium oleate (OTAB/NaOA) and cetylpyridinium chloride/sodium salicylate (CPCl/NaSal) using a capillary breakup extensional rheometer (CaBER) and a dripping onto substrate (DoS) technique. These wormlike micellar systems show a peak in zero shear viscosity or in the shear relaxation time beyond a critical surfactant or salt concentration Prior cryogenic transmission electron microscopy imaging has indicated that the system based on OTAB/NaOA experiences a transition from linear to shorter linear micelles (L-L) beyond the viscosity peak. However, the linear wormlike micelles based on CPCl/NaSal form branched networks beyond the viscosity peak (L-B). In this work, we investigate whether the extensional rheol. is sensitive to these two different microstructural transitions. In particular, we attempt to develop a criterion based on the extensional flow parameters in order to distinguish these two systems from each other. In addition, we probe the possibility of flow-induced micellar breakage imposed by capillary breakup extensional experiments Our results indicate that at a given zero shear viscosity, the branched wormlike micelles based on CPCl/NaSal exhibit a longer filament lifetime tfil than the linear wormlike micelles. However, beyond the critical concentration, the linear wormlike micelles based on OTAB/NaOA exhibit significantly shorter filament lifetimes than their linear counterparts at concentrations below the viscosity peak. More importantly, we show that the filament lifetime scales differently with zero shear viscosity η0 in these two systems. For L-B transition, tfilαη01.1 below the viscosity peak and tfilαη00.76above the viscosity peak. However, for L-L transition, this scaling remains the same for concentrations below and above the viscosity peak and reads as tfilαη00.5. These findings provide a novel criterion to distinguish these two types of microstructural transitions in wormlike micelles. On the other hand, we demonstrate that the Trouton ratio, filament lifetime, and the extensional relaxation time measured by CaBER technique are all lower than the ones obtained by DoS method. The latter result provides the first evidence for strong nonlinear effects (e.g., flow-induced micellar breakage) in capillary breakup extensional flows of wormlike micelles. (c) 2019 American Institute of Physics.

Journal of Rheology (Melville, NY, United States) published new progress about Dimensionless number, Weissenberg. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Name: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem