Category: 123-03-5

Abdul Rub, Malik; Alabbasi, Abdulrahman; Azum, Naved; Asiri, Abdullah M. published the artcile< Aggregation and surface phenomena of amitriptyline hydrochloride and cationic benzethonium chloride surfactant mixture in different media>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is amitriptyline hydrochloride benzethonium chloride surface phenomena aggregation.

Mixed association behavior of cationic nature of drug amitriptyline hydrochloride (AMHCl) and surfactant benzethonium chloride (BTC) have been studied at five mole fractions of BTC (α1) via surface tension (ST) and fluorescence methods at 298.15 K in occurrence of three dissimilar media (H2O, electrolyte (NaCl), urea (UR)) to evaluate the interactions present amongst them. The evaluated values of critical micelle concentration (cmc) come out beneath the values of cmcid (ideal cmc value) demonstrating attractive interactions amongst the studied constituents (AMHCl and BTC) within mixed micelles. Electrolyte decreases the cmc value of the system while the effect of UR is found to increase in cmc. The micellar mole fraction of BTC (XR1) analyzed by the Rubingh model in solution mixture, mole fraction at mixed monolayer (Xσ1) determined by Rosen model and argued in detail. The interaction parameter in the solution mixture (βRb) and at the interfacial surface (βσ) is constantly achieved neg. in the entire cases. Activity coefficients of the mixed micellar system (fRb1 (BTC) and fRb2 (AMHCl)) and mixed monolayer (fσ1 (BTC) and fσ2 (AMHCl)) were forever less than one telling the nonideal behavior of systems. Various surface parameters have been estimated along with various thermodn. parameters have also been assessed.

Journal of Molecular Liquids published new progress about Aggregation. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kaushik, Pradeep; Kaur, Gurpreet; Chaudhary, Ganga Ram; Batra, Uma published the artcile< Tuning the surface using palladium based metallosurfactant for hydrogen evolution reaction>, Safety of 1-Hexadecylpyridin-1-ium chloride, the main research area is electrolysis catalyst palladium cetylpyridinium chloride hydrogen evolution; Contact angle measurements; Electrocatalyst; Hydrogen evolution reaction; Metallosurfactant.

Synthesis of a novel electrocatalyst for hydrogen evolution reaction (HER) is highly demanding for renewable energy production This research reports the design and development of novel palladium based metallosurfactant (PdCPC(I)) that belongs to the unique class of inorganic-organic hybrid with striking structural features that are explored for the first time in the HER. The formation of the micelle, mol. orientation and surface characteristics of the metallosurfactant are calculated by conductivity and contact angle measurements. The reduction of palladium in metallomicelles during electrolysis accelerates the HER. Metallosurfactant makes the substrate hydrophilic, which in turn enhances the activity of the modified substrate. The 269 mV and 400 mV (vs. RHE) overpotential is required to achieve the 10 mA cm-2 of c.d. for PdCPC(I) and CPC, resp. Tafel slope of PdCPC(I) is 57 mV dec-1, which signifies that the reaction follows the Volmer- Heyrovsky mechanism in the presence of catalyst. The presence of the palladium in the core of the micelle is certified by ICPMS study. The present electrocatalyst also demonstrates 40 h of electrochem. durability. This work opens the doors toward the enhancement of HER, which fulfills the dreams for future energy resources.

Journal of Colloid and Interface Science published new progress about Contact angle. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Safety of 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gaudino, Danila; Costanzo, Salvatore; Ianniruberto, Giovanni; Grizzuti, Nino; Pasquino, Rossana published the artcile< Linear wormlike micelles behave similarly to entangled linear polymers in fast shear flows>, Related Products of 123-03-5, the main research area is linear wormlike micelle polymer shear flow.

We report shear startup data on solutions of entangled linear wormlike micelles, only differing in the concentration of a binding aromatic salt. Wormlike micelles behave similarly to ordinary polymers in fast shear flows, exhibiting pronounced overshoots as well as tiny undershoots in transient shear viscosity, before approaching the steady state. The analogy is here emphasized by successfully comparing data with predictions of a constitutive equation recently adopted for ordinary entangled polymers. In the fast shear flow, entangled linear wormlike micelles appear to align, stretch, and tumble just like polymeric chains.

Journal of Rheology (Melville, NY, United States) published new progress about Polymers, linear. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Related Products of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Haward, Simon J.; Kitajima, Naoyuki; Toda-Peters, Kazumi; Takahashi, Tsutomu; Shen, Amy Q. published the artcile< Flow of wormlike micellar solutions around microfluidic cylinders with high aspect ratio and low blockage ratio>, SDS of cas: 123-03-5, the main research area is wormlike micellar solution flow microfluidic cylinder.

We employ time-resolved flow velocimetry and birefringence imaging methods to study the flow of a well-characterized shear-banding wormlike micellar solution around a novel glass-fabricated microfluidic circular cylinder. In contrast with typical microfluidic cylinders, our geometry is characterized by a high aspect ratio α = H/W = 5 and a low blockage ratio β = 2r/W = 0.1, where H and W are the channel height and width, and the cylinder radius r = 20μm. The small cylinder radius allows access up to very high Weissenberg numbers 1.9 ≤ Wi = λMU/r ≤ 3750 while inertial effects remain entirely negligible (Reynolds number, Re < 10-4). At low Wi values, the flow remains steady and sym. and a birefringent region (indicating micellar alignment and tensile stress) develops downstream of the cylinder. Above a critical value Wic ≈ 60 the flow transitions to a steady asym. state, characterized as a supercritical pitchfork bifurcation, in which the fluid takes a preferential path around one side of the cylinder. At a second critical value Wic2 ≈ 130, the flow becomes time-dependent, with a characteristic frequency f0 ≈ 1/λM. This initial transition to time dependence has characteristics of a subcritical Hopf bifurcation. Power spectra of the measured fluctuations become complex as Wi is increased further, showing a gradual slowing down of the dynamics and emergence of harmonics. Soft Matter published new progress about Algorithm. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, SDS of cas: 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Khalaf, Mai M.; Gouda, Mohamed; Shalabi, Kamal; Shaaban, Saad; Abd El-Lateef, Hany M. published the artcile< Structural and Adsorptive Characteristics of 2D Multilayer Nanoflakes of NiCo Phosphates for Chromium(VI) Removal: Experimental and Monte Carlo Simulations>, Category: pyridine-derivatives, the main research area is multilayer nanoflake nickel cobalt phosphate chromium adsorption wastewater modeling.

Metal phosphates are efficient adsorbent materials for heavy elements present in industrial effluents because of their promising properties. Hexachromium ions are among the most dangerous contaminants owing to their harmful properties and non-degradability. Accordingly, the present work offers a simplified study of the preparation of bimetallic phosphate materials from nickel cobalt phosphate (NiCo-Ph) based on the sol-gel method in an equimolar ratio. Characterization of the bulk, crystal phase, texture profile, and nanosize of NiCo-Ph was carried out using various techniques such as Fourier transform IR spectroscopy, X-ray diffraction, XPS, nitrogen adsorption-desorption isotherm measurements, field emission SEM, transmission electron microscopy, and Raman spectroscopy. In this regard, the adsorption performance of NiCo-Ph was exemplified through six batch experiments, elucidating the impacts of the sorbent dose, initial concentration of pollutants, sorption time, temperature, pH, and shaking rate. According to UV/vis spectrophotometry measurements and their related calculations of NiCo-Ph, the maximum removal efficiency (RE %) of 92% and adsorption capacity (qm) of 37 mg/g were achieved at pH = 6, a dose of 5.0 g/L, 100 mg/L of [Cr(VI)], 300 rpm, adsorption time of 60 min, and 298 K. Monte Carlo simulations were also carried out to correlate the exptl. data with theor. calculations that provided a higher neg. value (-911.62 kcal mol-1) for the adsorption energy of Cr(VI) in acidic medium. The adsorbent NiCo-Ph prepared by this direct method is therefore recommended for the quantification of Cr(VI) under slightly acidic solutions and at room temperature, which can maintain its efficiency even up to six cycles.

ACS Omega published new progress about Adsorbents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Timmer, Niels; Gore, David; Sanders, David; Gouin, Todd; Droge, Steven T. J. published the artcile< Sorbent-modified biodegradation studies of the biocidal cationic surfactant cetylpyridinium chloride>, Application of C21H38ClN, the main research area is cetylpyridinium chloride biocidal cationic surfactant sorbent modified biodegradation; Bioaccessibility; Cationic surfactant; Cetylpyridinium chloride; Environmental risk assessment; Ready biodegradability testing; Toxicity mitigation.

Biodegradability studies for the cationic surfactant cetylpyridinium chloride (CPC) are hampered by inhibitory effects on inoculum at prescribed test concentrations (10-20 mg organic carbon/L). In this study, we used 14C labeled CPC in the 28 d Headspace Test (OECD 310) and demonstrated that CPC was readily biodegradable (10->60% mineralization within a 10 day window) at test concentrations 0.006-0.3 mg/L with CPC as single substrate. Biodegradation efficiency was comparable over this concentration range. CPC inhibited degradation at 1 mg/L and completely suppressed inoculum activity at 3 mg/L. In an extensive sorbent modified biodegradation study we evaluated the balance between CPC bioaccessibility and toxicity. A non-inhibitory concentration of 0.1 mg/L CPC was readily biodegradable with 83% sorbed to SiO2, while biodegradation was slower when 96% was sorbed. SiO2 mitigated inhibitory effects of 1 mg/L CPC, reaching >60% biodegradation within 28 d; inhibitory effects were also mitigated by addition of com. clay powder (illite) but this was primarily reflected by a reduced lag phase. At 10 mg/L CPC SiO2 was still able to mitigate inhibitory effects, but bioaccessibility seemed limited as only 20% biodegradation was reached. Illite limited bioaccessibility more strongly and was not able to sustain biodegradation at 10 mg/L CPC.

Ecotoxicology and Environmental Safety published new progress about Bioavailability. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Application of C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kim, Haewon; Yoo, Jean; Lim, Yeon-Mi; Kim, Eun-Ji; Yoon, Byung-Il; Kim, Pilje; Yu, Seung Do; Eom, Ig-Chun; Shim, Ilseob published the artcile< Comprehensive pulmonary toxicity assessment of cetylpyridinium chloride using A549 cells and Sprague-Dawley rats>, Application In Synthesis of 123-03-5, the main research area is pulmonary toxicity cetylpyridinium chloride; bronchoalveolar lavage fluid; cetylpyridinium chloride; inhalation toxicity; intratracheal instillation; polymorphonuclear leukocyte; quaternary ammonium compound.

Cetylpyridinium chloride (CPC), a quaternary ammonium compound and cationic surfactant, is used in personal hygiene products such as toothpaste, mouthwash, and nasal spray. Although public exposure to CPC is frequent, its pulmonary toxicity has yet to be fully characterized. Due to high risks of CPC inhalation, we aimed to comprehensively elucidate the in vitro and in vivo toxicity of CPC. The results demonstrated that CPC is highly cytotoxic against the A549 cells with a half-maximal inhibitory concentration (IC50) of 5.79μg/mL. Following CPC exposure, via intratracheal instillation (ITI), leakage of lactate dehydrogenase, a biomarker of cell injury, was significantly increased in all exposure groups. The bronchoalveolar lavage fluid (BALF) anal. showed a significant increase in proinflammatory cytokines interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α levels. ITI of CPC induced focal inflammation of the pulmonary parenchyma in rats lungs. Our study demonstrated that TNF-α was the most commonly secreted proinflammatory cytokine during CPC exposure in both in vitro and in vivo models. Polymorphonuclear leukocytes in the BALF, which are indicators of pulmonary inflammation, significantly increased in a concentration-dependent manner in all in vivo studies including the ITI, acute, and subacute inhalation assays, demonstrating that PMNs are the most sensitive parameters of pulmonary toxicity.

Journal of Applied Toxicology published new progress about Blood urea nitrogen. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Application In Synthesis of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhong, Jia-Yu; Cui, Xing-Jun; Zhan, Jun-Kun; Wang, Yan-Jiao; Li, Shuang; Lin, Xiao; Xiang, Qun-Yan; Ni, Yu-Qing; Liu, Le; Liu, You-Shuo published the artcile< LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells>, Category: pyridine-derivatives, the main research area is lncRNA Bhlhe40 glucose calcification senescence vascular smooth muscle cell; Bhlhe40; VSMC calcification/senescence; diabetes; lncRNA-ES3; microRNA; vascular aging.

Long noncoding RNAs (lncRNAs) have been investigated as novel regulatory mols. involved in diverse biol. processes. Our previous study demonstrated that lncRNA-ES3 is associated with the high glucose-induced calcification/senescence of human aortic vascular smooth muscle cells (HA-VSMCs). However, the mechanism of lncRNA-ES3 in vascular calcification/aging remained largely unknown. Here, we report that the expression of basic helix-loop-helix family member e40 (Bhlhe40) was decreased significantly in HA-VSMCs treated with high glucose, whereas the expression of basic leucine zipper transcription factor (BATF) was increased. Overexpression of Bhlhe40 and inhibition of BATF alleviated calcification/senescence of HA-VSMCs, as confirmed by Alizarin Red S staining and the presence of senescence-associated β-galactosidase-pos. cells. Moreover, we identified that Bhlhe40 regulates lncRNA-ES3 in HA-VSMCs by binding to the promoter region of the lncRNA-ES3 gene (LINC00458). Upregulation or inhibition of lncRNA-ES3 expression significantly promoted or reduced calcification/senescence of HA-VSMCs, resp. Addnl., we identified that lncRNA-ES3 functions in this process by suppressing the expression of miR-95-5p, miR-6776-5p, miR-3620-5p, and miR-4747-5p. The results demonstrate that lncRNA-ES3 triggers gene silencing of multiple miRNAs by binding to Bhlhe40, leading to calcification/senescence of VSMCs. Our findings suggest that pharmacol. interventions targeting lncRNA-ES3 may be therapeutically beneficial in ameliorating vascular calcification/aging.

Annals of the New York Academy of Sciences published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (CEBPE). 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Timmer, Niels; Gore, David; Sanders, David; Gouin, Todd; Droge, Steven T. J. published the artcile< Application of seven different clay types in sorbent-modified biodegradability studies with cationic biocides>, HPLC of Formula: 123-03-5, the main research area is cetyltrimethylammonium bromide cetylpyridinium chloride clay sorbent biodegradation toxicity mitigation; Bioaccessibility; Cationic surfactant; Clay minerals; Environmental risk assessment; Ready biodegradability testing; Toxicity mitigation.

The cationic surfactants cetyltrimethylammonium bromide (CTAB) and cetylpyridinium chloride (CPC) can exert inhibitory effects on micro-organisms responsible for their biodegradation However, under environmentally relevant exposure scenarios the presence of and sorption to organic and inorganic matter can lead to significant reduction of inhibitory effects. In our studies we investigated silica gel and seven clays as inert sorbents to mitigate these inhibitory effects in a 28 day manometric respirometry biodegradation test. CTAB was not inhibitory to the used inoculum, but we did observe that seven out of eight sorbents increased maximum attainable biodegradation, and four out of eight decreased the lag phase. The strongly inhibitory effect of CPC was successfully mitigated by most sorbents, with five out of eight allowing >50% biodegradation within 28 days. Results further indicate that bioaccessibility of the sorbed fractions in the stirred manometric test systems was higher than in calmly shaken headspace test systems. Bioaccessibility might also be limited depending on characteristics of test chem. and sorbent type, with montmorillonite and bentonite apparently providing the lowest level of bioaccessibility with CPC. Clay sorbents can thus be used as environmentally relevant sorbents to mitigate potential inhibitory effects of test chems., but factors that impede bioaccessibility should be considered. In addition to apparently increased bioaccessibility due to stirring, the automated manometric respirometry test systems give valuable and highly cost-effective insights into lag phase and biodegradation kinetics; information that is especially relevant for test chems. of gradual biodegradability.

Chemosphere published new progress about Bentonite Role: PEP (Physical, Engineering or Chemical Process), PROC (Process). 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, HPLC of Formula: 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Z. J.; Michniak-Kohn, B. published the artcile< Flavosomes, novel deformable liposomes for the co-delivery of anti-inflammatory compounds to skin>, Safety of 1-Hexadecylpyridin-1-ium chloride, the main research area is antiinflammatory drug NSAID topical flavonoid liposome skin permeation deformability; Deformable liposomes; Ex vivo skin permeation; Flavonoid; Flavosome; Meloxicam; Transfersome.

Flavosomes, novel deformable liposomes for the topical delivery of anti-inflammatory compounds have been developed and characterized in this study. The carriers were prepared by incorporating flavonoids, specifically quercetin and dihydroquercetin, into transfersome and evaluated as a potential topical delivery system for meloxicam (MX), a potent hydrophobic NSAID (non-steroidal anti-inflammatory drug). Characterization of the flavosomes was conducted in terms of their vesicle size, zeta potential, entrapment efficiency and deformability index. Ex vivo skin permeation and confocal laser scanning microscopy studies demonstrated that the flavosome formulations improved the skin permeation of meloxicam compared to that for transfersomes. The dermal and transdermal delivery of meloxicam using these formulations has the potential of being a promising alternative to conventional oral delivery of non-steroidal anti-inflammatory drugs (NSAIDs) with enhanced local and systemic onset of action and reduced gastrointestinal side effects.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about Biological permeation. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Safety of 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem