Category: 123148-66-3

Electric Literature of 123148-66-3 ,Some common heterocyclic compound, 123148-66-3, molecular formula is C7H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

C) 2-methoxyisonicotinaldehyde To a solution of (2-methoxypyridin-4-yl)methanol (6.74 g) and triethylamine (67.5 mL) in DMSO (200 mL) was added sulfur trioxide pyridine complex (30.8 g), and the mixture was stirred at room temperature for 30 min. Water was added to the reaction mixture at room temperature, and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. After silica gel filtration, the solvent was evaporated under reduced pressure to give a crude product of the title compound (4.33 g) as a brown oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,123148-66-3, its application will become more common.

Reference:
Patent; Takeda Pharmaceutical Company Limited; MIWATASHI, Seiji; SUZUKI, Hideo; OKAWA, Tomohiro; MIYAMOTO, Yasufumi; YAMASAKI, Takeshi; HITOMI, Yuko; HIRATA, Yasuhiro; EP2816032; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 123148-66-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 123148-66-3, name is (2-Methoxypyridin-4-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of the above compound (V2) (440 mg, 3.16 mmol) in CH2CI2 (12.6 ml) at room temperature was added drop-wise thionyl chloride (0.69 ml, 9.49 mmol). The resulting mixture was stirred at room temperature for 2 h. The solvent was removed. The residue was washed with sat. NaHC03 and extracted with CH2CI2. The combined organic layers were washed with brine, dried over anhydrous MgS04, filtered and concentrated to give 4-(chloromethyl)-2- methoxypyridine (V3) (400 mg, 80%) as a light yellow liquid. ES-MS [M+l]+: 158.1.

According to the analysis of related databases, 123148-66-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; SCHLEGEL, Kelly-Ann; YANG, Zhi-Qiang; WO2011/84368; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 123148-66-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 123148-66-3 as follows.

Manganese dioxide (1.04 g) was added to a solution of (2-methoxypyridin-4-yl)methanol (417 mg) in ethyl acetate (5 mL), followed by refluxing for 1.5 hours. Manganese dioxide (1.04 g) was added thereto, followed by refluxing for 1.5 hours. The reaction mixture was cooled to room temperature, the insoluble materials were filtered off, and the solvent was distilled off under reduced pressure. The obtained residues were purified by silica gel column chromatography (hexane:ethyl acetate=9:1?4:6), whereby 2-methoxyisonicotinic aldehyde (260 mg) was obtained as a colorless oily material

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,123148-66-3, its application will become more common.

Reference:
Patent; FUJIFILM Corporation; KUBO, Yohei; ANDO, Makoto; TANAKA, Hidehiko; OSAKA, Shuhei; MATSUMOTO, Takuya; NAKATA, Hiyoku; TERADA, Daisuke; NITABARU, Tatsuya; (379 pag.)US2016/168139; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 123148-66-3 ,Some common heterocyclic compound, 123148-66-3, molecular formula is C7H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 2: 3-(2, 6-d ifluoro-3 , 5-dimethoxyphenyl)-1-[(2-methoxypyridin-4-yl)methylJ-8-(morpholin-4-ylmethyl)- 7-(phenylsufonyl)-1, 3,4, 7-tetrahydro-2H-pyrrolo[3 ?,2 ?:5, 6Jpyrido[4, 3-dJpyrimidin-2-one To a solution of 3 -(2,6-difluoro-3 ,5 -dimethoxyphenyl)-8-(morpholin-4-ylmethyl)-7- (phenylsulfonyl)- 1,3 ,4,7-tetrahydro-2H-pyrrolo[3 ?,2? : 5,6]pyrido[4,3 -d]pyrimidin-2-one(10.0 mg, 0.0 167 mmol, from Step 1), (2-methoxypyridin-4-yl)methanol (23.2 mg,0.167 mmol, purchased from Ark Pharma, catalog number: AK-2 8607) in tetrahydrofuran (1.0 mL, 12 mmol) were added triphenylphosphine (26.0 mg, 0.099 1 mmol) and diethyl azodicarboxylate (16 iL, 0.10 mmol). The resulting mixture was stirred at 60 C for 12 h. The reaction was diluted with MeOH (4.0 mL) and purified by RP-HPLC (pH 10) toafford the product. LC-MS calculated for C35H35F2N607S [M+H] mlz: 721.2; found 721.0.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 123148-66-3, (2-Methoxypyridin-4-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; INCYTE CORPORATION; WU, Liangxing; ZHANG, Colin; HE, Chunhong; SUN, Yaping; LU, Liang; QIAN, Ding-Quan; XU, Meizhong; ZHUO, Jincong; YAO, Wenqing; WO2014/7951; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem