Category: 1232431-11-6

Application of 1232431-11-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1232431-11-6, name is 5-Bromo-4-methoxypyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

2-Amino-4-methoxy-5-bromopyridine (500 mg, 2.5 mmol) and 2- bromo- 4′- nitroacetophenone (1.21 g, 5.0 mmol) were dissolved in acetonitrile (40 mL) The solution was stirred at 85 degrees for 5h, After cooling to room temperature,A large number of yellow solid precipitation, filter, The filter cake was beaten with methanol (10 mL) Filter again The filter cake is vacuum dried, A yellow solid (360 mg, 42%) was obtained.

According to the analysis of related databases, 1232431-11-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sunshine Lake Pharma Co., Ltd.; Zhen, Changchun; Liu, Bing; Zhang, Weihong; Zhang, Yingjun; Long, Bohua; (59 pag.)CN104513257; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1232431-11-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1232431-11-6, name is 5-Bromo-4-methoxypyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

2-Amino-4-methoxy-5-bromopyridine (500 mg, 2.5 mmol) and 2- bromo- 4′- nitroacetophenone (1.21 g, 5.0 mmol) were dissolved in acetonitrile (40 mL) The solution was stirred at 85 degrees for 5h, After cooling to room temperature,A large number of yellow solid precipitation, filter, The filter cake was beaten with methanol (10 mL) Filter again The filter cake is vacuum dried, A yellow solid (360 mg, 42%) was obtained.

According to the analysis of related databases, 1232431-11-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sunshine Lake Pharma Co., Ltd.; Zhen, Changchun; Liu, Bing; Zhang, Weihong; Zhang, Yingjun; Long, Bohua; (59 pag.)CN104513257; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1232431-11-6 ,Some common heterocyclic compound, 1232431-11-6, molecular formula is C6H7BrN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-Bromo-4-methoxy-pyridin-2-ylamine (9.50 g, 46.79 mmol), hexane-2, 5-dione (7.08 mL, 60.83 mmol) and p-toluenesulfonic acid (0.81 g, 4.68 mmol) in toluene (80 mL) are stirred over night at l20C using a Dean-Stark-apparatus. The reaction mixture is concentrated under reduced pressure, taken up in DCM and purified by silica gel chromatography (DCM). Yield: 7.60 g (58%) ESI-MS: m/z = 281 and 283 [M+H]+ (Br-isotopic pattern) Rt(HPLC): 1.13 min (method 1)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1232431-11-6, 5-Bromo-4-methoxypyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BERRY, Angela Kay; BOUYSSOU, Thierry; GOTTSCHLING, Dirk; HEINE, Niklas; NETHERTON, Matthew Russell; (119 pag.)WO2019/161010; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem