Category: 1235865-75-4

Reference of 1235865-75-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1235865-75-4, name is Methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoate. This compound has unique chemical properties. The synthetic route is as follows.

Example 11 methyl 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)benzoate A mixture of EXAMPLE 1H (1.55 g), EXAMPLE 1E (2.42 g), and HK2PO4 (1.42 g) in dimethylsulfoxide (20 mL) at 135 C. was stirred for 24 hours. The reaction was cooled, diluted with ether (400 mL), and washed three times with 1M aqueous NaOH, and brine, and concentrated. The crude product was chromatographed on silica gel with 10-50% ethyl acetate/hexanes.

According to the analysis of related databases, 1235865-75-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Tao, Zhi-Fu; Wang, Xilu; Wendt, Michael; Souers, Andrew; Judd, Andrew; Kunzer, Aaron; Sullivan, Gerard; US2014/275082; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1235865-75-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1235865-75-4 as follows.

The mixture of (S)-6-(2- (2-cyclopropylphenyl) pyrrolidin-1-yl) -2-azaspiro [3.3] heptane (28.3 g, 0.1 mmol), methyl 2- ((1H-pyrrolo [2, 3-b] pyridin-5-yl) oxy) -4-fluorobenzoate (31.57 g, 0.11 mmol), Na 2CO 3 (106 g, 1 mol) in DMF (500 mL) was heated to 105 C and stirred for overnight. After cooled to room temperature, the reaction mixture was diluted with EA (1000 mL), washed with brine (1000 mL 2), dried over Na 2SO 4 and concentrated in vacuum to afford a residue, which was purified by chromatography column on silica gel (eluent: EA/PE = 1/5 to 1/1) to give the product (11.2 g) as an off-white solid. MS (ESI, m/e) [M+1] + 548.9.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1235865-75-4, its application will become more common.

Reference:
Patent; BEIGENE, LTD.; GUO, Yunhang; XUE, Hai; WANG, Zhiwei; SUN, Hanzi; (493 pag.)WO2019/210828; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1235865-75-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1235865-75-4, name is Methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoate. A new synthetic method of this compound is introduced below.

In 100mL2-Boc-octahydropyrrolyl [3,4-c] pyrrole (0.73 g, 3.4 mmol), 2-((1H-pyrrolo [2,3-b] pyridin-5-yl) oxy) -4-fluorobenzoic acidMethyl ester (1.00 g, 3.8 mmol), dipotassium hydrogen phosphate(2.28 g, 10 mmol) and 40 mL of DMSO were reacted at 130 C. for 6 h, cooled to room temperature, 50 mL of water and 30 mLEA, the layers were separated, the aqueous layer was extracted twice with 50 mL of EA, the combined organic phases were washed once with 50 mL of saturated brine,Dried over sodium sulfate, filtered and spin-dried to give 0.702 g of product in 43% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1235865-75-4, Methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoate, and friends who are interested can also refer to it.

Reference:
Patent; Sun Yat-sen University; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Kou Yuhui; Hu Bolin; Jiang Haigang; Ye Jiuyong; Liu Zhiqiang; Xie Hongming; Zhang Yingjun; Yan Ming; (39 pag.)CN106749233; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1235865-75-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1235865-75-4, name is Methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoate. This compound has unique chemical properties. The synthetic route is as follows.

(0085) A mixture of Compound 3H (1.55 g), Compound 3E (2.42 g), and HK2PO4 (1.42 g) in dimethylsulfoxide (20 ml) at 135 C. was stirred for 24 hours. The reaction was cooled, diluted with ether (400 ml), and washed with 3¡Á1M NaOH, and brine, and concentrated. The crude product was chromatographed on silica gel with 10-50% ethyl acetate/hexanes.

According to the analysis of related databases, 1235865-75-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AbbVie Inc.; Catron, Nathaniel; Lindley, David; Miller, Jonathan M.; Schmitt, Eric A.; Tong, Ping; US10213433; (2019); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem