Application of 123846-66-2, Adding some certain compound to certain chemical reactions, such as: 123846-66-2, name is 2-(5-Nitro-2-pyridinyl)acetonitrile,molecular formula is C7H5N3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 123846-66-2.
Sodium hydride (67.44 mmol) was added to a solution of 2-(5-nitropyridine-2-yl) acetonitrile (30.65 mmol) in dry THF (250 ml) at 0 C and the reaction mixture was stirred for 0.5 h. Methyl iodide (91.95 mmol) was added to the reaction mixture and reaction mixture was warmed to RT, stirred for another 24 h. Solvent was removed under vacuum; crude product was purified (silica gel column, EtOAc/hexane as eluent) to obtain the title compound. .H NMR (300 MHz, DMSO-d6): delta 9.43 (d, J=2.7 Hz, 1H), 8.55 (dd, J=8.7, 2.4 Hz, 1H), 7.86 (d, J = 8.7 Hz, 1H), 1.82 (s, 6H); MS (m/z): 192 (M+l)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 123846-66-2, 2-(5-Nitro-2-pyridinyl)acetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PIRAMAL LIFE SCIENCES LIMITED; KUMAR, Sanjay; SHARMA, Rajiv; ZAHLER, Robert; SAHU, Bichismita; AGARWAL, Veena, R.; NAIK, Nishigandha; WO2012/7926; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem