Category: 123853-39-4

Application of 123853-39-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.123853-39-4, name is 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid, molecular formula is C16H15Cl2NO4, molecular weight is 356.2, as common compound, the synthetic route is as follows.

Example-5: Preparation of Clevidipine:100 gm of 1 ,4-dihydro-2,6-dimethyl-4-(2′,3′-dichorophenyl)-5-methoxycarbonyl-3- pyridinecarboxylic acid and 35.4 gm of Sodium bicarbonate is stirred in DMF under nitrogen atmosphere. 49.9 gm of Chloromethyl butyrate was added and reaction mixture was heated at about 80C for 4 hrs. The solvent was distilled out and residue was treated with methylene chloride. The obtained reaction mass was washed with water and the methylene chloride layer was dried over sodium sulphate. Methylene chloride was distilled out under vacuum. Diisopropyl ether (800 ml) was added to the residual mass and stirred at 25-30C for one hour. The reaction mass was filtered, the wet cake was washed with diisopropyl ether to give crude clevidipine (Wt. = 97.5 gms HPLC Purity > 99%).

The chemical industry reduces the impact on the environment during synthesis 123853-39-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; CADILA PHARMACEUTICALS LIMITED; KHAMAR, Bakulesh Mafatlal; SHARMA, Arun Omprakash; PARIKH, Sanjay Natvarlal; BHATT, Achyut Pravinbhai; PANSURIYA, Akshay Madhubhai; JADEJA, Krunal Aniruddhbhai; BAPAT, Uday Rajaram; MODI, Indravadan Ambalal; WO2012/69989; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 123853-39-4 ,Some common heterocyclic compound, 123853-39-4, molecular formula is C16H15Cl2NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 1 preparation of intermediate 2.0 kg (5.61mol) inputs 10L in acetonitrile, inputs under stirring chloro-butyrate 850g (6.22mol) and potassium carbonate 860g (6.22mol), heating to reflux reaction 4-6h, cooling to room temperature, filter, filtrates in 40-50 C concentrated under reduced pressure to dry, subsequently joined 4L ethyl acetate, reflux is dissolved, and 45g activated carbon decolourizations 5-15min, hot filtering, filtrates in 30-40 C dropwise 7L-hexane crystallization, filtration, 40-50 C decompression drying to obtain the butyric acid clevidipine 2.38 kg, yield 92.89%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,123853-39-4, its application will become more common.

Reference:
Patent; Hefei long promise Pharmaceutical Technology Co; Wu, biao; Ling, lin; Wang, zhouhong; Dai, yij; (10 pag.)CN105461619; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 123853-39-4, 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 123853-39-4, blongs to pyridine-derivatives compound. Product Details of 123853-39-4

The 75mg about 0.21mmol prepared above S14,80mg, about 0.21mmol compound S12,55mg about 0.4mmol K2CO3 in single-neck flask, 5mL DMF, in a nitrogen atmosphere Heated to 50 C, the reaction 2h, cooled to 30 C overnight reaction, until the reaction is complete, add 20mL Water was added and extracted with chloroform, the organic phases were pooled washed with water and saturated brine, dried over anhydrous sodium sulfate Dry, filtered, and solvent was removed by rotary evaporation, the residue was purified by column chromatography to give the present invention provides Compound 9,46mg, a yield of 35%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,123853-39-4, its application will become more common.

Reference:
Patent; JiangsuSimcere Pharmaceutical Company, Ltd; JiangsuSimcere Pharmaceutical Research Co. Ltd.; Chen, Rong; Liu, Fei; Cong, Xin; Feng, Lin; Li, Haidao; Dong, Qingli; (62 pag.)CN102464608; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 123853-39-4, name is 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C16H15Cl2NO4

Compound 7 (300 mg, 0.83 mmol), NaHC03 (150 mg, 1.66 mmol) was dissolved in DMF (8 ml), compound 8 (170 mg, 1.24 mmol) was added under N2 and heated to 80 C reflux, 4 hours The organic layer was washed with saturated brine, dried over anhydrous NaS04 and separated by column chromatography to obtain clovipid butyrate (250 mg,65% yield)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 123853-39-4, 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid.

Reference:
Patent; ARROMAX PHARMATECH SUZHOU CO LTD; JIAN, HONG; XU, XIN; (12 pag.)CN104230792; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 123853-39-4 ,Some common heterocyclic compound, 123853-39-4, molecular formula is C16H15Cl2NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 2 – Purification of 5-methoxycarbonyl-4-(2,3-dichlorophenyl)-2,6- dimethyl-1 ,4-dihydropyridine-3-carboxylic acid[0021] The crude carboxylic acid 2 from Example 1 (126g, 0.35 mol) was dissolved in a mixture of methanol (230ml_) and a solution of NaOH (34. Og, 0.85 mol) in water (230ml_). The solution was extracted with dichloromethane, and brine was added to the aqueous layer. The solids were collected by filtration and then re-suspended in water and stirred vigorously for 2h, after which the reaction mixture was cooled in an ice-water bath and phosphoric acid (85%, 21 ml_) was added. The solids were collected by filtration and washed with water. After drying under vacuum at 40C, compound 2 was suspended in a 1 : 1 mixture of acetone and heptane and vigorously stirred for 2h. The solids were collected by filtration and washed with heptane. Drying under high vacuum at 40C gave carboxylic acid 2 as a beige powder (95 g, 75% yield, 46%overall yield). Analysis by HPLC indicates a purity of 97.28%, with 0.13% of diacid 5 present.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 123853-39-4, 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ALPHORA RESEARCH INC.; SOUZA, Fabio; PAN, Ming; WO2011/130852; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 123853-39-4, name is 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid, the common compound, a new synthetic route is introduced below. COA of Formula: C16H15Cl2NO4

4-(2′,3′-dichlorophenyl)-2,6-dimethyl-5-(methoxycarbonyl)-1,4-dihydropyridin-3-carboxylic acid (20.0g, 56.2mmol), Potassium carbonate (32.lg, 232.5 mmol), lithium iodide (3.86 g, 23.2 mmol) was addedDMF (300 ml), and chloromethyl n-butyrate was added(31.6 g, 232.5 mmol) at 70 C for 4 h. The reaction solution was cooled to roomThe organic layer was separated, dried and the solvent was removed. A solid precipitated and a pale yellow solid was obtained by filtration. The filter cake was washed with 250 ml of methanol / water (100 ml)(1/1, volume ratio) to obtain 61.6 g of a solid, 87.2% yield.

The synthetic route of 123853-39-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanghai Institute of Pharmaceutical Industry; Li J, ianqi; Zheng, Yongyong; Fang, Gan; Zhang, Li; (9 pag.)CN103242220; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 123853-39-4, name is 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C16H15Cl2NO4

Compound 7 (300 mg, 0.83 mmol), NaHC03 (150 mg, 1.66 mmol) was dissolved in DMF (8 ml), compound 8 (170 mg, 1.24 mmol) was added under N2 and heated to 80 C reflux, 4 hours The organic layer was washed with saturated brine, dried over anhydrous NaS04 and separated by column chromatography to obtain clovipid butyrate (250 mg,65% yield)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 123853-39-4, 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid.

Reference:
Patent; ARROMAX PHARMATECH SUZHOU CO LTD; JIAN, HONG; XU, XIN; (12 pag.)CN104230792; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 123853-39-4 ,Some common heterocyclic compound, 123853-39-4, molecular formula is C16H15Cl2NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 2 – Purification of 5-methoxycarbonyl-4-(2,3-dichlorophenyl)-2,6- dimethyl-1 ,4-dihydropyridine-3-carboxylic acid[0021] The crude carboxylic acid 2 from Example 1 (126g, 0.35 mol) was dissolved in a mixture of methanol (230ml_) and a solution of NaOH (34. Og, 0.85 mol) in water (230ml_). The solution was extracted with dichloromethane, and brine was added to the aqueous layer. The solids were collected by filtration and then re-suspended in water and stirred vigorously for 2h, after which the reaction mixture was cooled in an ice-water bath and phosphoric acid (85%, 21 ml_) was added. The solids were collected by filtration and washed with water. After drying under vacuum at 40C, compound 2 was suspended in a 1 : 1 mixture of acetone and heptane and vigorously stirred for 2h. The solids were collected by filtration and washed with heptane. Drying under high vacuum at 40C gave carboxylic acid 2 as a beige powder (95 g, 75% yield, 46%overall yield). Analysis by HPLC indicates a purity of 97.28%, with 0.13% of diacid 5 present.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 123853-39-4, 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ALPHORA RESEARCH INC.; SOUZA, Fabio; PAN, Ming; WO2011/130852; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 123853-39-4, name is 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid, the common compound, a new synthetic route is introduced below. COA of Formula: C16H15Cl2NO4

4-(2′,3′-dichlorophenyl)-2,6-dimethyl-5-(methoxycarbonyl)-1,4-dihydropyridin-3-carboxylic acid (20.0g, 56.2mmol), Potassium carbonate (32.lg, 232.5 mmol), lithium iodide (3.86 g, 23.2 mmol) was addedDMF (300 ml), and chloromethyl n-butyrate was added(31.6 g, 232.5 mmol) at 70 C for 4 h. The reaction solution was cooled to roomThe organic layer was separated, dried and the solvent was removed. A solid precipitated and a pale yellow solid was obtained by filtration. The filter cake was washed with 250 ml of methanol / water (100 ml)(1/1, volume ratio) to obtain 61.6 g of a solid, 87.2% yield.

The synthetic route of 123853-39-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanghai Institute of Pharmaceutical Industry; Li J, ianqi; Zheng, Yongyong; Fang, Gan; Zhang, Li; (9 pag.)CN103242220; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem