Category: 124870-33-3

Synthetic Route of 124870-33-3, Adding some certain compound to certain chemical reactions, such as: 124870-33-3, name is Methyl 2-(3-cyanopyridin-4-yl)acetate,molecular formula is C9H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 124870-33-3.

Preparation of Intermediate 4-(2-hydroxyethyl)nicotinonitrile (I-65b) NaBH4 (228 mg, 6.023 mmol) was added portion wise over a period of 20 minutes to a solution of methyl 2-(3-cyanopyridin-4-yl)acetate (I-65a: 530 mg, 3.011 mmol) in ethanol (6 mL) at 0 C. and the resulting reaction mass was stirred at 0 C. for 4 hours. The reaction was monitored by TLC (50% ethyl acetate in hexane). The reaction mass was quenched with saturated NH4Cl solution and extracted using ethyl acetate. The organic layer was washed with water, brine solution, dried over Na2SO4 and concentrated under reduced pressure to afford the crude product. Purification by column chromatography on silica gel (2% methanol in DCM) afforded 100 mg of the product (22.42% yield). 1H NMR (300 MHz, CDCl3): delta 8.85 (s, 1H), 8.7 (d, 1H), 7.4 (d, 1H), 4.0 (t, 2H), 3.1 (t, 2H). LCMS: 99.03%, m/z=149.1 (M+1)

According to the analysis of related databases, 124870-33-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra; US2014/45872; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 124870-33-3, name is Methyl 2-(3-cyanopyridin-4-yl)acetate, the common compound, a new synthetic route is introduced below. HPLC of Formula: C9H8N2O2

1.58g of (3-cyano-pyridine-4-yl) -acetic acid methyl ester was dissolved in 18 mL of ethanol and slowly added with 682mg of sodium borohydride at-0 C and stirred for about 2 hours. The above mixture was added with 3 mL of saturated solution of ammonium chloride, diluted with 200 mL ethylacetate. Then, the organic solvent layer was washed with water, and saturated solution of sodium chloride, dried with anhydrous sodium sulfate and filtered. The filtrate was concentreated under reduced pressure and a silica gel column chromatography was performed on the resulting residue by using a mixed eluant of methylene chloride and methanol, wherein methylene chloride and methanol are mixed in 50: 1 volume ratio, and 1.02g (74%) of 4- (2-hydroxy-ethyl)-nicotinonitrile was obtained in colorless oil. 1H NMR (300 MHz, CDCI3) 8 8. 82 (s, 1H), 8.69 (d, 1H, J=5. 4Hz), 7.39 (d, 1H, J=5. 4Hz), 3.99 (t, 2H, J=6. 3Hz), 3.10 (t, 2H, J=6. 3Hz).

The synthetic route of 124870-33-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SK CHEMICALS, CO., LTD.; WO2005/63768; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem