Electric Literature of 1256788-36-9 ,Some common heterocyclic compound, 1256788-36-9, molecular formula is C7H5ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Synthesis of Intermediate (2)Molecular Weight: 168.58 Molecular Weight: 202.66[00619] In a 25-mL,3N round-bottomed flask equipped with thermometer pocket fitted with a nitrogen inlet and a rubber septum, Intermediate- 1 (0.25 g, 1.0 eq.), MgCl2 6H20 (0.3616 g, 1.2 eq.), NaSH (0.099 g) was dissolved in DMF (3 mL). The reaction mixture was stirred at25-30C. The progress of the reaction was followed by TLC analysis on silica gel with30%EtOAc- hexane as mobile phase which shows that starting material was consumed after30 minutes staring at 25-30C. Reaction was quenched in water, precipitate was filtered by filter paper and wash with hexane to give required compound. Reaction was stirred for 10 min with water solid were separated and compound was collected and washed with hexane(30mL).Yield: 0.180 g (60%).Mass: (ES+) 202.7(M+1), 200.8(M-1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1256788-36-9, 2-Chloro-6-methoxyisonicotinonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; KARYOPHARM THERAPEUTICS, INC.; SHECHTER, Sharon; KAUFFMAN, Michael; SANDANYAKA, Vincent, P.; SHACHAM, Sharon; WO2011/109799; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem