Category: 1256823-07-0

Application of 1256823-07-0, Adding some certain compound to certain chemical reactions, such as: 1256823-07-0, name is 5-Bromo-4-methoxypicolinonitrile,molecular formula is C7H5BrN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1256823-07-0.

To a stirred solution of 4-methyl-1H-imidazole (580 mg, 7.04 mmol) in acetonitrile (24 mL) under an argon atmosphere were added potassium carbonate (1.3 g, 9.38 mmol) and 18-crown-6 (2.47 g, 9.38 mmol) at room temperature. The reaction mixture was stirred at 60 oC for 2 h. Then 5-bromo-4-methoxypicolinonitrile (1 g, 4.69 mmol) was added to the reaction mixture at room temperature. The reaction mixture was stirred at reflux for 18 h. After consumption of the starting material (monitored by TLC), the reaction mixture was diluted with water (20 mL) and extracted with EtOAc (2 x 30 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by column chromatography using 90% EtOAc:hexanes to afford 4- methoxy-5-(4-methyl-1H-imidazol-1-yl) picolinonitrile (250 mg, 25%) as a yellow solid. 1H- NMR (CDCl3, 500 MHz): delta 8.58 (s, 1H), 7.82 (s, 1H), 7.39 (s, 1H), 6.99 (s, 1H), 401 (s, 3H), 2.23 (s, 3H); LCMS: 215 (M+1); (column; X-Bridge C-18 (50 × 3.0 mm, 3.5 mum); RT 2.45 min. 0.05% Aq TFA: ACN; 0.8 mL/min); TLC: EtOAc (Rf: 0.2).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1256823-07-0, 5-Bromo-4-methoxypicolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/109109; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1256823-07-0, Adding some certain compound to certain chemical reactions, such as: 1256823-07-0, name is 5-Bromo-4-methoxypicolinonitrile,molecular formula is C7H5BrN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1256823-07-0.

To a stirred solution of 4-methyl-1H-imidazole (580 mg, 7.04 mmol) in acetonitrile (24 mL) under an argon atmosphere were added potassium carbonate (1.3 g, 9.38 mmol) and 18-crown-6 (2.47 g, 9.38 mmol) at room temperature. The reaction mixture was stirred at 60 oC for 2 h. Then 5-bromo-4-methoxypicolinonitrile (1 g, 4.69 mmol) was added to the reaction mixture at room temperature. The reaction mixture was stirred at reflux for 18 h. After consumption of the starting material (monitored by TLC), the reaction mixture was diluted with water (20 mL) and extracted with EtOAc (2 x 30 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by column chromatography using 90% EtOAc:hexanes to afford 4- methoxy-5-(4-methyl-1H-imidazol-1-yl) picolinonitrile (250 mg, 25%) as a yellow solid. 1H- NMR (CDCl3, 500 MHz): delta 8.58 (s, 1H), 7.82 (s, 1H), 7.39 (s, 1H), 6.99 (s, 1H), 401 (s, 3H), 2.23 (s, 3H); LCMS: 215 (M+1); (column; X-Bridge C-18 (50 × 3.0 mm, 3.5 mum); RT 2.45 min. 0.05% Aq TFA: ACN; 0.8 mL/min); TLC: EtOAc (Rf: 0.2).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1256823-07-0, 5-Bromo-4-methoxypicolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/109109; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1256823-07-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1256823-07-0, name is 5-Bromo-4-methoxypicolinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

Synthesis of 4-methoxy-5-(4-methyl-lH-imidazol-l-yl) picolino nitrile [0324] To a stirred solution of 4-methyl-lH-imidazole (580 mg, 7.04 mmol) in acetonitrile (24 mL) under argon atmosphere were added potassium carbonate (1.3 g, 9.38 mmol) and 18 crown-6 (2.47 g, 9.38 mmol) at RT. The reaction mixture was stirred at 60 C for 2 h. Then 5-bromo-4-methoxypicolinonitrile (1 g, 4.69 mmol) was added to the reaction mixture and stirred at reflux for 18 h. After consumption of the starting materials (monitored by TLC), the reaction was diluted with water (20 mL) and extracted with EtOAc (2 x 30 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by silica gel column chromatography using 90%> EtOAc:hexanes to afford 4-methoxy-5-(4-methyl-lH-imidazol-l-yl) picolino nitrile (250 mg, 25%) as a yellow solid. 1H-NMR (CDC13, 500 MHz): delta 8.58 (s, 1H), 7.82 (s, 1H), 7.39 (s, 1H), 6.99 (s, 1H), 401 (s, 3H), 2.23 (s, 3H); LC-MS: 215 (M+l); (column; X-Bridge C-18 (50 3.0 mm, 3.5 mu); RT 2.45 min. 0.05% Aq TFA: ACN; 0.8 mL/min); TLC: EtOAc (R 0.2).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1256823-07-0, 5-Bromo-4-methoxypicolinonitrile.

Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66697; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1256823-07-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1256823-07-0, name is 5-Bromo-4-methoxypicolinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

Synthesis of 4-methoxy-5-(4-methyl-lH-imidazol-l-yl) picolino nitrile [0324] To a stirred solution of 4-methyl-lH-imidazole (580 mg, 7.04 mmol) in acetonitrile (24 mL) under argon atmosphere were added potassium carbonate (1.3 g, 9.38 mmol) and 18 crown-6 (2.47 g, 9.38 mmol) at RT. The reaction mixture was stirred at 60 C for 2 h. Then 5-bromo-4-methoxypicolinonitrile (1 g, 4.69 mmol) was added to the reaction mixture and stirred at reflux for 18 h. After consumption of the starting materials (monitored by TLC), the reaction was diluted with water (20 mL) and extracted with EtOAc (2 x 30 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by silica gel column chromatography using 90%> EtOAc:hexanes to afford 4-methoxy-5-(4-methyl-lH-imidazol-l-yl) picolino nitrile (250 mg, 25%) as a yellow solid. 1H-NMR (CDC13, 500 MHz): delta 8.58 (s, 1H), 7.82 (s, 1H), 7.39 (s, 1H), 6.99 (s, 1H), 401 (s, 3H), 2.23 (s, 3H); LC-MS: 215 (M+l); (column; X-Bridge C-18 (50 3.0 mm, 3.5 mu); RT 2.45 min. 0.05% Aq TFA: ACN; 0.8 mL/min); TLC: EtOAc (R 0.2).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1256823-07-0, 5-Bromo-4-methoxypicolinonitrile.

Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66697; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1256823-07-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1256823-07-0, name is 5-Bromo-4-methoxypicolinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

Synthesis of 4-methoxy-5-(4-methyl-lH-imidazol-l-yl) picolino nitrile [0324] To a stirred solution of 4-methyl-lH-imidazole (580 mg, 7.04 mmol) in acetonitrile (24 mL) under argon atmosphere were added potassium carbonate (1.3 g, 9.38 mmol) and 18 crown-6 (2.47 g, 9.38 mmol) at RT. The reaction mixture was stirred at 60 C for 2 h. Then 5-bromo-4-methoxypicolinonitrile (1 g, 4.69 mmol) was added to the reaction mixture and stirred at reflux for 18 h. After consumption of the starting materials (monitored by TLC), the reaction was diluted with water (20 mL) and extracted with EtOAc (2 x 30 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by silica gel column chromatography using 90%> EtOAc:hexanes to afford 4-methoxy-5-(4-methyl-lH-imidazol-l-yl) picolino nitrile (250 mg, 25%) as a yellow solid. 1H-NMR (CDC13, 500 MHz): delta 8.58 (s, 1H), 7.82 (s, 1H), 7.39 (s, 1H), 6.99 (s, 1H), 401 (s, 3H), 2.23 (s, 3H); LC-MS: 215 (M+l); (column; X-Bridge C-18 (50 3.0 mm, 3.5 mu); RT 2.45 min. 0.05% Aq TFA: ACN; 0.8 mL/min); TLC: EtOAc (R 0.2).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1256823-07-0, 5-Bromo-4-methoxypicolinonitrile.

Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66697; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1256823-07-0 ,Some common heterocyclic compound, 1256823-07-0, molecular formula is C7H5BrN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 3. Preparation of 4-methoxy-5-(4-methyl-1 /-/-imidazol-1 -yl)pyridine-2- carbonitrile (C3). 4-Methyl-1 /-/-imidazole (15 g, 0.18 mol), potassium carbonate (34 g, 0.25 mol) and 18-crown-6 (64 g, 0.24 mol) were combined in acetonitrile (600 mL), and the reaction mixture was heated to 60 C for 2 hours. 5-Bromo-4- methoxypyridine-2-carbonitrile (C2) (25 g, 0.12 mol) was added in one portion, and the reaction was heated to reflux for 18 hours. After being combined with an identical reaction mixture, the reaction was partitioned between water (500 mL) and ethyl acetate (500 mL). The aqueous layer was extracted with ethyl acetate (2 x 300 mL), and the combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated. Purification by chromatography on silica (Gradient: 1 :10 to 1 :2 ethyl acetate: petroleum ether) provided the title product as a white solid. Yield: 8.2 g, 0.038 mol, 16%. NMR (400 MHz, CDCI3) delta 2.30 (d, J=1 Hz, 3H), 4.02 (s, 3H), 6.96-6.97 (m, 1 H), 7.38 (s, 1 H), 7.82 (d, J=1.5 Hz, 1 H), 8.53 (s, 1 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1256823-07-0, 5-Bromo-4-methoxypicolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER INC.; AM ENDE, Christopher William; JOHNSON, Douglas Scott; O’DONNELL, Christopher John; PETTERSSON, Martin Youngjin; SUBRAMANYAM, Chakrapani; WO2011/48525; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem