Category: 127406-56-8

Electric Literature of 127406-56-8, Adding some certain compound to certain chemical reactions, such as: 127406-56-8, name is 4-Pyridin-2-yl-benzaldehyde,molecular formula is C12H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127406-56-8.

EXAMPLE 13; Synthesis of 3,5-dichloro-4-(pyridine-2-yl)benzaldehyde (5b)In a 40 mL tube, 4-(pyridine-2-yl)benzaldehyde (0.3 mmol, 1 equiv) and CuCl2 (8.1 mg, 0.06 mmol, 20% equiv) were dissolved in 1 mL of CI2CHCHCI2 under oxygen. The tube was sealed with a Teflon lined cap, and the reaction mixture was stirred at 1300C for 24 h. The reaction mixture was diluted with 20 mL of CH2CI2 and then treated with 10 mL of saturated Na2S aqueous solution. The mixture was filtered through a pad of Celite, and the filtrate was washed twice with brine. The organic layer was dried over Na2SO4 and concentrated under vacuum. After purification by column chromatography on silica gel with a gradient eluent of hexane and ether (Rf = 0.12 in 2:1 hexane: ether), the title product was obtained as a white solid (62.0 mg, 82%).1H NMR (400 MHz, CDCl3) delta 9.99 (s, IH), 8.78 (d, J= 4.8 Hz, IH), 7.92 (s, 2H), 7.86 (td, J= 8.0, 1.2 Hz, IH), 7.41-7.39 (m, H), 7.35 (d, J= 8.0 Hz, IH); 13C NMR (100 MHz, CDCl3) delta 189.60, 154.86, 150.23, 143.90, 137.66, 136.98, 136.34, 129.27, 124.98, 123.82; IR (thin film) v 3067, 1706, 1549, 1364, 1200 cm” ‘; HRMS (TOF) Calcd for Ci2H8Cl2NO (M + H) 258.0452, found 258.0456.

According to the analysis of related databases, 127406-56-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRANDEIS UNIVERSITY; WO2007/123910; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 127406-56-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 127406-56-8 as follows.

EXAMPLE 5; Synthesis of 3-hydroxy-4-(pyridine-2-yl)benzaldehyde (5a)In a 20 mL tube, 4-(pyridine-2-yl)benzaldehyde (0.3 mmol, 1 equiv), Cu(OAc)2 (54.6 mg, 0.3 mmol, 1 equiv) and H2O (5.4 muL, 0.3 mmol, 1 equiv) were dissolved in 1 mL of dry MeCN under oxygen. The tube was sealed with a Teflon lined cap, and the reaction mixture was stirred at 1300C for 36 h. The reaction mixture was diluted with 20 mL Of CH2Cl2 and then treated with 10 mL of saturated Na2S aqueous solution. The mixture was filtered through a pad of Celite, and the filtrate was washed twice with brine. The organic layer was dried over Na2SO4 and concentrated under vacuum. After purification by column chromatography on silica gel with a gradient eluent of hexane and ether (Rf = 0.29 in 2:1 hexane: ether), the title product was obtained as a pale yellow solid (25.7 mg, 43%). 1H NMR (400 MHz, CDCl3) delta 14.59 (s, IH), 10.00 (s, IH), 8.58 (d, J = 4.8 Hz, IH), 8.02-7.92 (m, 3H), 7.50 (s, IH), 7.44 (d, J= 8.4 Hz, IH), 7.36 (t, J= 7.2 Hz, IH); 13C NMR (100 MHz, CDCl3) delta 191.93, 160.41, 156.55, 146.09, 138.34, 138.15, 126.74, 123.73, 122.75, 120.49, 120.01, 118.71; IR (thin film) v 3055, 1698, 1594, 1419, 1265 cm”1; HRMS (TOF) Calcd for C12Hi0NO2 (M + H) 200.0712, found 200.0708.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,127406-56-8, its application will become more common.

Reference:
Patent; BRANDEIS UNIVERSITY; WO2007/123910; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 127406-56-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 127406-56-8 as follows.

EXAMPLE 5; Synthesis of 3-hydroxy-4-(pyridine-2-yl)benzaldehyde (5a)In a 20 mL tube, 4-(pyridine-2-yl)benzaldehyde (0.3 mmol, 1 equiv), Cu(OAc)2 (54.6 mg, 0.3 mmol, 1 equiv) and H2O (5.4 muL, 0.3 mmol, 1 equiv) were dissolved in 1 mL of dry MeCN under oxygen. The tube was sealed with a Teflon lined cap, and the reaction mixture was stirred at 1300C for 36 h. The reaction mixture was diluted with 20 mL Of CH2Cl2 and then treated with 10 mL of saturated Na2S aqueous solution. The mixture was filtered through a pad of Celite, and the filtrate was washed twice with brine. The organic layer was dried over Na2SO4 and concentrated under vacuum. After purification by column chromatography on silica gel with a gradient eluent of hexane and ether (Rf = 0.29 in 2:1 hexane: ether), the title product was obtained as a pale yellow solid (25.7 mg, 43%). 1H NMR (400 MHz, CDCl3) delta 14.59 (s, IH), 10.00 (s, IH), 8.58 (d, J = 4.8 Hz, IH), 8.02-7.92 (m, 3H), 7.50 (s, IH), 7.44 (d, J= 8.4 Hz, IH), 7.36 (t, J= 7.2 Hz, IH); 13C NMR (100 MHz, CDCl3) delta 191.93, 160.41, 156.55, 146.09, 138.34, 138.15, 126.74, 123.73, 122.75, 120.49, 120.01, 118.71; IR (thin film) v 3055, 1698, 1594, 1419, 1265 cm”1; HRMS (TOF) Calcd for C12Hi0NO2 (M + H) 200.0712, found 200.0708.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,127406-56-8, its application will become more common.

Reference:
Patent; BRANDEIS UNIVERSITY; WO2007/123910; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 127406-56-8, name is 4-Pyridin-2-yl-benzaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4-Pyridin-2-yl-benzaldehyde

To a solution of 3, 4, 5-piperidinetriol, 2- (hydroxymethyl)-, (2S, 3R, 4R, [5S)] [(50MG,] 0. [31MMOL)] in methanol [(2ML)] was added 4- (2-pyridyl) benzaldehyde (280mg, 1. [53MMOL).] The mixture was stirred for 5 min until fully dissolved. The pH was adjusted to 5 by addition [OF METHANOLIC HCI (1M),] then (polystyrylmethyl) trimethylammonium cyanoborohydride (180mg, 0. [78MMOL)] was added. The resultant mixture was stirred at room temperature for 48 [H.] The crude reaction mixture was purified using a plug of acidic Dowex 50X4-200 resin [(1.] [5G),] which had been pre-washed with 10% aqueous hydrochloric acid, followed by water then methanol. The resin was eluted with methanol [(25ML)] to remove all non-basic side products. The desired compound was then eluted using a solution of 2: 2: 1 [METHANOL/WATER/AMMONIUM] hydroxide [(50ML).] The solution was concentrated to a small volume [(~LML)] and freeze dried. The resulting residue was crystallised from [METHANOL/ETHYL] acetate to give the title product (80mg, [78%).’H] NMR (d4-methanol) 8 2.63 [(1H,] dd, [J =] 9.6, 12. [2 HZ),] 2.73 [(1H,] dd, J = 5.1, 12. [2 HZ),] 3.11 [(1H,] m), 3.40 [(1H,] t, J [= 9.] 0 Hz), 3.53 [(1H,] m), 3.78 [(1H,] dd, J = 5.3, 9.0 Hz), 3.88-4. 03 (4H, m), 7.35 [(1H,] m), 7.50 [(2H,] d, J [= 8.] 3 Hz), 7.82-7. 90 (4H, m), 8.59 [(1H,] d, J = 4.9 Hz). MS [M/Z] 331.3 (M+H) +.

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Reference:
Patent; OXFORD GLYCOSCIENCES (UK) LTD; WO2004/7453; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem