Category: 127561-18-6

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 127561-18-6, name is 1-(6-(Trifluoromethyl)pyridin-2-yl)piperazine, the common compound, a new synthetic route is introduced below. Quality Control of 1-(6-(Trifluoromethyl)pyridin-2-yl)piperazine

A solution of 4-fluorophenyl /V-5-[(zPatent; CENTAURUS THERAPEUTICS; ROMERO, Donna, L.; BLITZER, Jeremy; (242 pag.)WO2019/140188; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 127561-18-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 127561-18-6, name is 1-(6-(Trifluoromethyl)pyridin-2-yl)piperazine. A new synthetic method of this compound is introduced below.

A-9 (0.33g, 1.40mmol), C-1 (0.30g, 1.30mmol),Triethylamine Anhydrous(0.263 g, 2.60 mmol) was dissolved in 25 mL of anhydrous acetonitrile, and HATU (0.513 g, 1.40 mmol) was added, and the reaction was performed at room temperature for 30 min. After the reaction, it was diluted with water, extracted with ethyl acetate, washed with dilute hydrochloric acid, washed with sodium bicarbonate solution, washed with saturated brine, dried over anhydrous sodium sulfate, filtered, concentrated and purified by silica gel column chromatography (PE: EA = 2: 1, v / v) to obtain 470.385 g of the compound with a yield of 66.6%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,127561-18-6, 1-(6-(Trifluoromethyl)pyridin-2-yl)piperazine, and friends who are interested can also refer to it.

Reference:
Patent; Hangzhou Weitan Pharmaceutical Technology Co., Ltd.; Cheng Yunfeng; Hu Yongzhou; (45 pag.)CN110357833; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.127561-18-6, name is 1-(6-(Trifluoromethyl)pyridin-2-yl)piperazine, molecular formula is C10H12F3N3, molecular weight is 231.22, as common compound, the synthetic route is as follows.HPLC of Formula: C10H12F3N3

Add 4- (6-TRIFLUOROMETHYL-2-PYRIDYL) piperazine (46 mg, 0. 2 mmol) to a solution of 4- [6-CHLORO-2- (3-CHLOROPHENYL) PYRIMIDIN-4-YL] morpholine (62 mg, 0. 2 mmol), PD2 (dba) 3 (18 mg, 0. 02 MMOL), and BINAP (17 mg, 0. 02 mmol) in toluene (2 mL) under nitrogen, followed by t-BuOK (45 mg, 0. 4 mmol). Stir the mixture at 90C for 8 hours, dilute with aqueous ammonium chloride, and extract with EtOAc (3 x 10 mL). Dry (MGS04) the combined extracts and concentrate under reduced pressure. Purify the residue using flash chromatography on silica gel (50% hexane/50% ether) to give the title compound. MS 505 (M+ 1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,127561-18-6, 1-(6-(Trifluoromethyl)pyridin-2-yl)piperazine, and friends who are interested can also refer to it.

Reference:
Patent; NEUROGEN CORPORATION; WO2005/7648; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem