Category: 127978-70-5

Related Products of 127978-70-5 , The common heterocyclic compound, 127978-70-5, name is (5-Methoxypyridine-2-yl)methanol, molecular formula is C7H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-methoxypyridine-2-carbaldehyde: To a solution of 5.7g (41 mmol) (5-methoxypyridin-2~ yl)methanol in 100 mL CHC I3 was added 15g MnO2 and the mixture heated to reflux for 2 hours, filtered, and washed with boiling CHCI3. The filtrate was washed with brine, dried over MgSO4, and concentrated in vacuo to afford 5-methoxypyridine-2-carbaldehyde as a white solid. IH NMR (400MHz5 CDCl3) delta 9.99 (s, IH), 8.44 (d, J=2.4Hz, IH), 7.97 (d, J=8.4Hz, IH), 7.3 (dd, J=8.4, 2.4Hz, IH), 3.95 (s, 2H)

The synthetic route of 127978-70-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2007/120729; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 127978-70-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 127978-70-5, name is (5-Methoxypyridine-2-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

5-(2-fluoroethoxy)-2-[[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-pyridine (B-19) Following the procedure for the preparation of compound B-4, but substituting (5-methoxypyridin-2-yl)methanol for [5-(2-fluoroethoxy)-pyridin-2-yl]-methanol provided compound B-19 (56.3%) as a white solid after treatment with diisopropyl ether. C24H22F2N4O2. LCMS: Rt 3.48, m/z 437 [M+H]+ (method 5). 1H NMR (400 MHz, CDCl3) delta ppm 4.22-4.34 (m, 2 H), 4.47 (dt, J=27.1, 4.9 Hz, 2 H), 4.70-4.87 (m, 2 H), 4.84 (dt, J=46.9, 4.6 Hz, 2 H), 5.18 (s, 2 H), 6.97 (br. d, J=8.8 Hz, 2 H), 7.16-7.21 (m, 2 H), 7.27 (dd, J=8.6, 2.8 Hz, 1 H), 7.36-7.42 (m, 2 H), 7.46 (d, J=8.6 Hz, 1 H), 7.70 (s, 1 H), 8.33 (d, J=2.8 Hz, 1 H), 8.45-8.52 (m, 2 H).

According to the analysis of related databases, 127978-70-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Andres-Gil, Jose Ignacio; De Angelis, Meri; Bormans, Guy Maurits R.; Celen, Sofie Jeanne Leopoldine; US2012/213703; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 127978-70-5 ,Some common heterocyclic compound, 127978-70-5, molecular formula is C7H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3-(2-fluoroethoxy)-2-[[4-[1-(3-fluoropropyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]pyridine.succinate (B-13) Following the procedure for the preparation of compound B-5, but substituting (5-methoxypyridin-2-yl)methanol for [3-(2-fluoroethoxy)-pyridin-2-yl]-methanol and 1-10 for intermediate compound 1-8, provided final compound B-13 that was converted into the corresponding succinic acid salt, in a similar way as it is described above for final compound B-3, which was crystallized from diethyl ether/diiisopropyl ether yielding the succinic acid salt of final compound B-13 (39.2%) as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 127978-70-5, (5-Methoxypyridine-2-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Andres-Gil, Jose Ignacio; De Angelis, Meri; Bormans, Guy Maurits R.; Celen, Sofie Jeanne Leopoldine; US2012/213703; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem