Category: 128071-75-0

Recommanded Product: 128071-75-0In 2021 ,《Microwave accelerated Castagnoli-Cushman reaction: Synthesis of novel 6,7,8,9-tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazines》 was published in Tetrahedron Letters. The article was written by Vytla, Devaiah; Shaw, Parinita; Velayuthaperumal, Rajeswari; Emmadi, Jithendra; Mathur, Arvind; Roy, Amrita. The article contains the following contents:

The Castagnoli-Cushman reaction of various azaindole dicarboxylic acids with imines using acetic anhydride as a dehydrating agent was significantly accelerated by microwave irradiation The reaction conditions offered a convenient preparation of novel 6,7,8,9-tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazines I [R1 = H, MeO, Cl, X = CH, N; Y = CH, N; Z = CH, N; R2 = 4-MeC6H4, 3-FC6H4, 4-MeOC6H4, 4-NO2C6H4, 2-thienyl; R3 = n-Pr, cyclopropyl, 4-MeC6H4, etc.] in moderate to good yields with good trans stereoselectivity. In the experiment, the researchers used many compounds, for example, 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Recommanded Product: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Metal Catalyzed Synthesis of Dihydropyridobenzodiazepines》 were Maddess, Matthew L.; Li, Chaomin. And the article was published in Organometallics in 2019. Quality Control of 2-Bromonicotinaldehyde The author mentioned the following in the article:

A versatile synthesis of dihydropyridobenzodiazepines that proceeds via a palladium-catalyzed C-N coupling and catalytic hydrogenation cascade is reported. The intermediate 2-anilinonicotinaldehydes may be efficiently protected to ultimately afford N6 differentiated dihydropyridobenzodiazepines, which facilitates further elaboration. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Quality Control of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Quality Control of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Chen, Yi; Liu, Di; Wang, Rui; Xu, Li; Tan, Jingyao; Shu, Mao; Tian, Lingfeng; Jin, Yuan; Zhang, Xiaoke; Lin, Zhihua published an article in Journal of Organic Chemistry. The title of the article was 《Bronsted Acid-Catalyzed : Synthesis of Phenanthrenes via Phosphomolybdic Acid as a Catalyst》.Formula: C6H4BrNO The author mentioned the following in the article:

Herein, disclosed a synthetic protocol for the synthesis of phenanthrenes such as I [R = H, Me; R1 = H, Me, OMe, etc.; R2 = H, F, OMe, etc.; R3 = H, OTIPS; R4 = H, F, Cl, etc.] through the CCOM with the inexpensive, nontoxic phosphomolybdic acid as a catalyst. The current annulations could realized carbonyl-olefin, carbonyl-alc., and acetal-alc. in situ CCOM reactions and feature mild reaction conditions, simple manipulation and scalability, making this strategy a promising alternative to the Lewis acid-catalyzed COM reaction.2-Bromonicotinaldehyde(cas: 128071-75-0Formula: C6H4BrNO) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Formula: C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 128071-75-0In 2017 ,《Approach to 5-substituted 6,7,8,9-tetrahydro-5H-pyrido[3,2-c]azepines》 appeared in Tetrahedron Letters. The author of the article were Subota, Andrii I.; Artamonov, Oleksiy S.; Gorlova, Alina; Volochnyuk, Dmitriy M.; Grygorenko, Oleksandr O.. The article conveys some information:

An approach to 5-substituted 6,7,8,9-tetrahydro-5H-pyrido[3,2-c]azepines via the cyclization of 1-(2-(3-azidopropyl)pyridin-3-yl)alkanones under Staudinger-aza-Wittig reaction conditions is described (I → II using PMe3; R = Ph, 4-FC6H4, i-Pr). The overall reaction sequence includes eight steps and allows for the preparation of gram quantities of the title products. In some cases, the formation of 5,7,8,9-tetrahydrooxepino[4,3-b]pyridine derivatives was observed The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Recommanded Product: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Yao, Qiyi; Kong, Lingkai; Zhang, Fangfang; Tao, Xianghua; Li, Yanzhong published 《Base-Promoted Tandem Reaction towards Conjugated Dienone or Chromone Derivatives with a Cyano Group: Insertion of Alkynes into C-C σ-Bonds of 3-Oxopropanenitriles》.Advanced Synthesis & Catalysis published the findings.Application of 128071-75-0 The information in the text is summarized as follows:

Base-promoted insertion reactions of alkynes into the C-C σ-bonds of α-cyano ketones were established to construct highly functionalized conjugated olefins I [R1 = cyclohexyl, Ph, 4-BrC6H4, 3,4,5-(MeO)3C6H2, etc.; R2 = Ph, 4-ClC6h4, 4-MeC6H4, 4-MeOC6H4; R3 = Ph] or chromone derivatives II [X = CH, N; R3 = t-Bu, Ph; R4 = H, 6-F, 7-F, 6,7-(MeO)2; R5 = Me, n-Bu, Ph, 3,4,5-(MeO)3C6H2, 2-naphthyl, etc.] via transition metal-free tandem reactions. Nucleophilic attack of α-cyano ketones R3C(O)CH2CN to alkynones R1C(O)CCR2 followed by intramol. nucleophilic addition/ring-opening furnished the cyano-containing alkenes I. In the cases of alkynones III (Z = Br, Cl, F) bearing an ortho-halide-substituted aryl ring, a further C-O bond coupling reaction occurred to afford chromone derivatives II in good to high yields. Various alkynones bearing alkyl or aryl substituents were compatible in the reaction. This reaction has the potential to become a general synthetic protocol for the preparation of cyano-substituted olefins and chromones due to the abundance of easily accessible starting materials possessing diverse substituent groups. In the part of experimental materials, we found many familiar compounds, such as 2-Bromonicotinaldehyde(cas: 128071-75-0Application of 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Application of 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Cs2CO3 Catalyzed Intramolecular Aminocarbonylation of Alkynes: Synthesis of 3-Amino-1H-inden-1-ones from N-tert-Butyl-2-(1-alkynyl)benzaldimines》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Guo, Zhen; Liu, Tao; Liang, Xiujuan; Wu, Yuting; Yao, Tuanli. Recommanded Product: 2-Bromonicotinaldehyde The article mentions the following:

Synthesis of a wide variety of 3-amino-1H-inden-1-ones I [R1 = H, 5-F, 6-Cl, etc.; R2 = Ph, 2-MeC6H4, 4-CO2EtC6H4, etc.] from N-tert-butyl-2-(1-alkynyl)benzaldimines via intramol. aminocarbonylation of alkynes using Cs2CO3 as catalyst and air as oxidant was developed. This highly atom-efficient, transition-metal-free reaction proceeded under thermal conditions. The reaction proceeded through an unprecedented 5-exo-dig cyclization of N-tert-butyl-2-(1-alkynyl)benzaldimines and thermal rearrangement of 3-methylene-2λ2-isoindolin-1-ols was proposed.2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 2-Bromonicotinaldehyde) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Asymmetric Synthesis of Multifunctionalized 2,3-Benzodiazepines by a One-pot N-Heterocyclic Carbene/Chiral Palladium Sequential Catalysis》 was published in Journal of Organic Chemistry in 2020. These research results belong to Ding, Ya-Li; Zhao, Yun-Long; Niu, Shuang-Shuo; Wu, Pei; Cheng, Ying. Computed Properties of C6H4BrNO The article mentions the following:

The first example of the construction of chiral 2,3-benzodiazepine compounds which are of biol. and pharmaceutical relevance by asym. catalysis is reported. Catalyzed by a thiazolium derived carbene and a palladium-chiral bidentate phosphine complex in sequence, one-pot reaction between 1-(2-(2-nitrovinyl)aryl)allyl esters with azodicarboxylates took place efficiently at ambient temperature to produce 4-nitro-1-vinyl-1H-2,3-benzodiazepine-2,3-dicarboxylates I (R = Me, Et, iPr; Z = C, N; X, Y = H, Me, Cl, etc.) in good to excellent yields with an enantiomeric ratio up to 95 : 5. In the part of experimental materials, we found many familiar compounds, such as 2-Bromonicotinaldehyde(cas: 128071-75-0Computed Properties of C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Computed Properties of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Bioorganic Chemistry included an article by Benchekroun, Mohamed; Pachon-Angona, Irene; Luzet, Vincent; Martin, Helene; Oset-Gasque, Maria-Jesus; Marco-Contelles, Jose; Ismaili, Lhassane. SDS of cas: 128071-75-0. The article was titled 《Synthesis, antioxidant and Aβ anti-aggregation properties of new ferulic, caffeic and lipoic acid derivatives obtained by the Ugi four-component reaction》. The information in the text is summarized as follows:

We report herein the synthesis antioxidant and Aβ anti-aggregation capacity of (E)-N-benzyl-N-[2-(benzylamino)-2-oxoethyl]-3-(aryl)acrylamides and related (R)-N-benzyl-N-(2-(benzylamino)-2-oxoethyl)-5-(1,2-dithiolan-3-yl)pentanamides 1-12. These compounds have been obtained, via Ugi four-component reaction, from modest to good yields. Their antioxidant anal., using the DPPH and ORAC assays, allowed us to identify compounds 8 and 9, as potent antioxidant agents, showing also strong Aβ1-40 self-aggregation inhibition, two biol. properties of interest in pathologies linked to the oxidative stress, such as Alzheimer’s disease. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0SDS of cas: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.SDS of cas: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Wang, Shao-Bo; Gu, Qing; You, Shu-Li published 《Rhodium(III)-Catalyzed C-H Alkynylation of Ferrocenes with Hypervalent Iodine Reagents》.Journal of Organic Chemistry published the findings.Product Details of 128071-75-0 The information in the text is summarized as follows:

Rapid access to mono- or dialkynylation of ferrocene with ethynylbenziodoxolones as the alkynylation reagents was achieved via Rh-catalyzed direct C-H bond functionalization at room temperature Mono- and dialkynylation were easily modulated by varying the sterical volume of the directing group, such as pyridine and isoquinoline, and amount of hypervalent I reagents. A wide range of ferrocene-based alkynylation products could be obtained in up to 94% yield, and a gram-scale reaction also proceeded smoothly with high efficiency. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0Product Details of 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Product Details of 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Luo, Guanglin; Chen, Ling; Conway, Charles M.; Kostich, Walter; Johnson, Benjamin M.; Ng, Alicia; Macor, John E.; Dubowchik, Gene M. published 《Asymmetric Synthesis of the Major Metabolite of a Calcitonin Gene-Related Peptide Receptor Antagonist and Mechanism of Epoxide Hydrogenolysis》.Journal of Organic Chemistry published the findings.SDS of cas: 128071-75-0 The information in the text is summarized as follows:

An asym. synthesis of the major metabolite, I, of the calcitonin gene-related peptide receptor antagonist BMS-846372 is presented. The variously substituted cyclohepta[b]pyridine ring system represents an underexplored ring system and showed some unexpected chem. Reactivities of epoxide and ketone functional groups on the cycloheptane ring were extensively controlled by a remote bulky TIPS group. The rate difference of the hydrogenolysis between two diastereomeric epoxide intermediates shed some light on the mechanism of epoxide hydrogenolysis; and further, deuterium labeling studies revealed more mechanistic details on this well-known chem. transformation for the first time. In the experiment, the researchers used 2-Bromonicotinaldehyde(cas: 128071-75-0SDS of cas: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.SDS of cas: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem