Category: 128071-75-0

In 2017,Faggyas, Reka J.; Calder, Ewen D. D.; Wilson, Claire; Sutherland, Andrew published 《One-Pot Asymmetric Synthesis of Alkylidene 1-Alkylindan-1-ols Using Bronsted Acid and Palladium Catalysis》.Journal of Organic Chemistry published the findings.Electric Literature of C6H4BrNO The information in the text is summarized as follows:

A one-pot catalytic enantioselective allylboration/Mizoroki-Heck reaction of 2-bromoaryl ketones has been developed for the asym. synthesis of 3-methyleneindanes bearing a tertiary alc. center. Bronsted acid-catalyzed allylboration with a chiral BINOL derivative was followed by a palladium-catalyzed Mizoroki-Heck cyclization, resulting in selective formation of the exo-alkene. This novel protocol provides a concise and scalable approach to 1-alkyl-3-methyleneindan-1-ols in high enantiomeric ratios (up to 96:4 er). The potential of these compounds as chiral building blocks was demonstrated with efficient transformation to optically active diol and amino alc. scaffolds. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0Electric Literature of C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Electric Literature of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Faggyas, Reka J.; Calder, Ewen D. D.; Wilson, Claire; Sutherland, Andrew published 《One-Pot Asymmetric Synthesis of Alkylidene 1-Alkylindan-1-ols Using Bronsted Acid and Palladium Catalysis》.Journal of Organic Chemistry published the findings.Electric Literature of C6H4BrNO The information in the text is summarized as follows:

A one-pot catalytic enantioselective allylboration/Mizoroki-Heck reaction of 2-bromoaryl ketones has been developed for the asym. synthesis of 3-methyleneindanes bearing a tertiary alc. center. Bronsted acid-catalyzed allylboration with a chiral BINOL derivative was followed by a palladium-catalyzed Mizoroki-Heck cyclization, resulting in selective formation of the exo-alkene. This novel protocol provides a concise and scalable approach to 1-alkyl-3-methyleneindan-1-ols in high enantiomeric ratios (up to 96:4 er). The potential of these compounds as chiral building blocks was demonstrated with efficient transformation to optically active diol and amino alc. scaffolds. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0Electric Literature of C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Electric Literature of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Cu(I)-Catalyzed Ligand-Free Tandem One-Pot or Sequential Annulation via Knoevenagel Intermediates: An Entry into Multifunctional Naphthalenes, Phenanthrenes, Quinolines, and Benzo[b]carbazoles》 was published in Journal of Organic Chemistry in 2020. These research results belong to Sunke, Rajnikanth; Kalyani, Adula; Swamy, K. C. Kumara. Product Details of 128071-75-0 The article mentions the following:

A simple but efficient one-pot or sequential copper-catalyzed protocol using 2-bromoaldehydes and active methylene group containing substrates that affords multifunctional naphthalenes, phenanthrenes, quinolines, and benzo[b]carbazoles via Knoevenagel condensation, C-arylation, and decarboxylation, followed by aromatization, is developed. The reaction utilizes the potential of Knoevenagel intermediates and does not require any ancillary ligand. The phenanthrene products thus obtained show moderate fluorescence activity. Structural elaboration of the products to obtain dihydrobenzoquinazolines is also highlighted. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0Product Details of 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Product Details of 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Makarian, Makar; Gonzalez, Michael; Salvador, Stephanie M.; Lorzadeh, Shahrokh; Hudson, Paula K.; Pecic, Stevan published an article in Journal of Molecular Structure. The title of the article was 《Synthesis, kinetic evaluation and molecular docking studies of donepezil-based acetylcholinesterase inhibitors》.Computed Properties of C6H4BrNO The author mentioned the following in the article:

In an effort to develop new therapeutic agents to treat Alzheimer′s disease, a series of donepezil-based analogs were designed, synthesized using an environmentally friendly route, and biol. evaluated for their inhibitory activity against elec. eel acetylcholinesterase (AChE) enzyme. In vitro studies revealed that the Ph moiety of donepezil can be successfully replaced with a pyridine ring leading to equally potent inhibitors of elec. eel AChE. Further kinetic evaluations of the most potent inhibitor showed a dual-binding (mixed inhibition) mode, similar to donepezil. Mol. modeling studies suggest that several addnl. residues could be involved in the binding of this inhibitor in the human AChE enzyme active site compared to donepezil. The experimental part of the paper was very detailed, including the reaction process of 2-Bromonicotinaldehyde(cas: 128071-75-0Computed Properties of C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Computed Properties of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 2-BromonicotinaldehydeIn 2018 ,《Thiobarbiturates as potential antifungal agents to control human infections caused by Candida and Cryptococcus species》 was published in Medicinal Chemistry Research. The article was written by Shabeer, Muhammad; Barbosa, Luiz C. A.; Karak, Milandip; Coelho, Amanda C. S.; Takahashi, Jacqueline A.. The article contains the following contents:

Hospitalized patients can suffer from Candida and Crytptococcus infections, aggravating underlying health conditions. Due to the development of drug-resistant microorganisms, we report here on the potential of some arylidene-thiobarbiturate to control five Candida spp. and one Cryptococcus species of medical interest. Initially, a bismuth nitrate catalyzed Knoevenagel condensation with thiobarbituric acid and aromatic aldehydes was developed. This new procedure generated seven new and thirteen known arylidene-thiobarbiturate derivatives (1-20) with excellent yields (81-95%), with a reaction time within 20 min. The antimicrobial activities of all compounds were evaluated against Candida albicans, C. tropicalis, C. parapsilosis, C. lusitaniae, C. dubliniensis, and Cryptococcus neoformans. Several compounds were as active as the com. available drugs (IC50 < 1.95 μg mL-1) towards at least one microbial strain. The results suggest that some of the new compounds can serve as leads for new antimicrobial agents for the treatment of human fungal infections. In the experiment, the researchers used many compounds, for example, 2-Bromonicotinaldehyde(cas: 128071-75-0Quality Control of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Quality Control of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors》 was written by Huang, Chunhui; Fischer, Christian; Machacek, Michelle R.; Bogen, Stephane; Biftu, Tesfaye; Huang, Xianhai; Reutershan, Michael H.; Otte, Ryan; Hong, Qingmei; Wu, Zhicai; Yu, Yang; Park, Min; Chen, Lei; Biju, Purakkattle; Knemeyer, Ian; Lu, Ping; Kochansky, Christopher J.; Hicks, Michael Brendan; Liu, Yong; Helmy, Roy; Fradera, Xavier; Donofrio, Anthony; Close, Josh; Maddess, Matthew L.; White, Catherine; Sloman, David L.; Sciammetta, Nunzio; Lu, Jun; Gibeau, Craig; Simov, Vladimir; Zhang, Hongjun; Fuller, Peter; Witter, David. Recommanded Product: 128071-75-0This research focused ontricyclic diazepine preparation SAR mutant isocitrate dehydrogenase inhibitor. The article conveys some information:

Efforts to reduce the electron-rich nature of the core were described. Ultimately, a strategy focused on core modifications to block metabolic hot spots coupled with substitution pattern changes (C8 N → C linked) led to the identification of new tricyclic analogs such as I (R1 = 1-aza-4-oxa[2.2.2]bicyclooctyl; R2 = trans-4-isopropoxycyclohexyl) with minimal GSH-adduct formation across species while maintaining an overall balanced profile.2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Phosphoramidates as Transient Precursors of Nitrogen-Centered Radical Under Visible-Light Irradiation: Application to the Synthesis of Phthalazine Derivatives》 was written by De Abreu, Maxime; Selkti, Mohamed; Belmont, Philippe; Brachet, Etienne. Application of 128071-75-0 And the article was included in Advanced Synthesis & Catalysis in 2020. The article conveys some information:

Phosphoramidates are for the first time presented as efficient N-Centered Radical (NCR) precursors under visible-light irradiation More precisely among this class of phosphorus-derived compounds, the radical reactivity of phosphonohydrazones, e.g I, was studied, under mild reaction conditions, which allowed the synthesis of a wide and diversified library of the scarcely reported phthalazine scaffold. Mechanistic investigations confirmed the formation of a NCR from these brand-new phosphonohydrazones (derivatived from phosphoramidates), which were further engaged in an intramol. 6-exo-dig cyclization to provide phthalazines. Compared to other pre-activated moieties, the phosphoramidate group is self-immolative, thus enhancing its attractiveness for the C-N bond formation. In the part of experimental materials, we found many familiar compounds, such as 2-Bromonicotinaldehyde(cas: 128071-75-0Application of 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application of 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Downs, Ryan P.; Xiao, Zhousheng; Ikedionwu, Munachi O.; Cleveland, Jacob W.; Chin, Ai Lin; Cafferty, Abigail E.; Darryl Quarles, L.; Carrick, Jesse D. published their research in Bioorganic & Medicinal Chemistry in 2021. The article was titled 《Design and development of FGF-23 antagonists: Definition of the pharmacophore and initial structure-activity relationships probed by synthetic analogues》.Reference of 2-Bromonicotinaldehyde The article contains the following contents:

Hereditary hypophosphatemic disorders, TIO, and CKD conditions are believed to be influenced by an excess of Fibroblast Growth Factor-23 (FGF-23) which activates a binary renal FGFRs/α-Klotho complex to regulate homeostatic metabolism of phosphate and vitamin D. Adaptive FGF-23 responses from CKD patients with excess FGF-23 frequently lead to increased mortality from cardiovascular disease. A reversibly binding small mol. therapeutic has yet to emerge from research and development in this area. Current outcomes described in this work highlight efforts related to lead identification and modification using organic synthesis of strategic analogs to probe structure-activity relationships and preliminarily define the pharmacophore of a computationally derived hit obtained from virtual high-throughput screening. Synthetic strategies for the initial hit and analog preparation, as well as preliminary cellular in vitro assay results highlighting sub micromolar inhibition of the FGF-23 signaling sequence at a concentration well below cytotoxicity are reported herein. In the experiment, the researchers used 2-Bromonicotinaldehyde(cas: 128071-75-0Reference of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C6H4BrNOIn 2019 ,《An approach to the synthesis of 3-substituted piperidines bearing partially fluorinated alkyl groups》 was published in Journal of Fluorine Chemistry. The article was written by Subota, Andrii I.; Ryabukhin, Sergey V.; Gorlova, Alina O.; Grygorenko, Oleksandr O.; Volochnyuk, Dmitriy M.. The article contains the following contents:

An approach to the synthesis of 3-substituted piperidines bearing partially fluorinated alkyl groups I [X = Y = H, F; R = H, Me, i-Pr] was proposed. The method was based on the DAST-mediated nucleophilic fluorination of easily available 2-bromopyridin-3-yl alcs. and ketones affording 2-bromo-3-(1-fluoroalkyl)pyridines and 2-bromo-3-(1,1-difluoroalkyl)pyridines II [R1 = H, Me, i-Pr, Ph; R2 = H, F], followed by catalytic hydrogenation. The hydrogenation step was studied with common heterogeneous Pd-, Pt-, and Rh-based catalyst. It was found that in the case of fluoroalkyl derivatives, the pyridine core reduction was accompanied by hydrodefluorination, which became a limitation of the strategy. Nevertheless, the method worked well with 1,1-difluoroalkyl derivatives The results came from multiple reactions, including the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Electric Literature of C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Electric Literature of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Robles, Andrew J.; McCowen, Shelby; Cai, Shengxin; Glassman, Michaels; Ruiz, Francisco; Cichewicz, Robert H.; McHardy, Stanton F.; Mooberry, Susan L. published 《Structure-Activity Relationships of New Natural Product-Based Diaryloxazoles with Selective Activity against Androgen Receptor-Positive Breast Cancer Cells》.Journal of Medicinal Chemistry published the findings.Safety of 2-Bromonicotinaldehyde The information in the text is summarized as follows:

Targeted therapies for ER+/PR+ and HER2-amplified breast cancers have improved patient survival, but there are no therapies for triple neg. breast cancers (TNBC) that lack expression of estrogen and progesterone receptors (ER/PR), or amplification or overexpression of HER2. Gene expression profiling of TNBC has identified mol. subtypes and representative cell lines. An extract of the Texas native plant Amyris texana was found to have selective activity against MDA-MB-453 cells, a model of the luminal androgen receptor (LAR) subtype of TNBC. Bioassay-guided fractionation identified two oxazole natural products with selective activity against this cell line. Conducted analog synthesis and structure-activity relationship studies provided analogs with more potent and selective activity against two LAR subtype cell line models, culminating in the discovery of compound I (CIDD-0067106). Lead compounds discovered have potent and selective antiproliferative activities, and mechanisms of action studies show they inhibit the activity of the mTORC1 pathway. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Safety of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem