Category: 128071-75-0

In 2017,Zhang, Fangfang; Yao, Qiyi; Yuan, Yang; Xu, Murong; Kong, Lingkai; Li, Yanzhong published 《Base-mediated insertion reaction of alkynes into carbon-carbon σ-bonds of ethanones: synthesis of hydroxydienone and chromone derivatives》.Organic & Biomolecular Chemistry published the findings.Computed Properties of C6H4BrNO The information in the text is summarized as follows:

Transition-metal free insertions of alkynes into C-C σ-bonds of ethanones are reported. These tandem reactions offer an efficient synthesis of hydroxydienones and multi-substituted chromones. This is the 1st example of base-promoted insertion reactions of isolated C-C triple bonds into C-C σ-bonds with active methylene compounds bearing only one electron-withdrawing group. The results came from multiple reactions, including the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Computed Properties of C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Computed Properties of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stahlberger, M.; Steinlein, O.; Adam, C. R.; Rotter, M.; Hohmann, J.; Nieger, M.; Koeberle, B.; Braese, S. published an article in 2022. The article was titled 《Fluorescent annulated imidazo[4,5-c]isoquinolines via a GBB-3CR/imidoylation sequence – DNA-interactions in pUC-19 gel electrophoresis mobility shift assay》, and you may find the article in Organic & Biomolecular Chemistry.Electric Literature of C6H4BrNO The information in the text is summarized as follows:

The development of a sequential synthesis route towards annulated imidazo[4,5-c]isoquinolines comprising a GBB-3CR, followed by an intramol. imidoylative cyclization was reported. X-Ray crystallog. revealed a flat 3D structure of the obtained polyheterocycles. Thus, their interactions with double-stranded DNA was evaluated by establishing a pUC-19 plasmid-based gel electrophoresis mobility shift assay, revealing a stabilizing effect on ds-DNA against strand-break inducing conditions.2-Bromonicotinaldehyde(cas: 128071-75-0Electric Literature of C6H4BrNO) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Electric Literature of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 2-BromonicotinaldehydeIn 2018 ,《Synthesis of Pyrimidine Fused Quinolines by Ligand-Free Copper-Catalyzed Domino Reactions》 appeared in Journal of Organic Chemistry. The author of the article were Panday, Anoop Kumar; Mishra, Richa; Jana, Asim; Parvin, Tasneem; Choudhury, Lokman H.. The article conveys some information:

Herein we report two novel methods for the synthesis of pyrimidine fused quinolines using one-pot C-C and C-N bond forming strategy from the reaction of 6-amino uracils with 2-bromo benzaldehydes or 2-bromobenzyl bromide derivatives in the presence of 10-mol% CuCl2 without using any ligand. The reaction of 2-bromobenzaldehyde or its derivatives with 6-amino-uracils in the presence K2CO3 as base and catalytic amount of CuCl2 in DMF medium under microwave heating conditions provide corresponding pyrimidine-fused quinoline derivatives in good yields within 30 min. Alternatively, pyrimidine fused quinoline derivatives have been synthesized from the reaction of 2-bromobenzyl bromides with 6-amino-uracil derivatives in the presence of mol. oxygen, CuCl2 (10-mol%) and K2CO3 as base in DMF under reflux conditions. Structures of all the products were unambiguously confirmed by spectroscopic techniques and by recording single crystal XRD of I. In addition to this study using 2-Bromonicotinaldehyde, there are many other studies that have used 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 2-Bromonicotinaldehyde) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C6H4BrNOIn 2018 ,《Synthetic Access to Functionalized Dipolarophiles of Lewis Basic Complexant Scaffolds through Sonogashira Cross-Coupling》 was published in Journal of Organic Chemistry. The article was written by Chaudhuri, Sauradip; Carrick, Jesse D.. The article contains the following contents:

Soft Lewis basic complexants that facilitate selective removal of discrete ions resident in spent nuclear fuel can decrease repository volume and radiotoxicity and are of significant interest. Optimization of chelation efficacy is predicated on modular access to synthons to rapidly evaluate structure-activity relationships. The following work highlights efficient access to functionalized synthons for use as potential dipolarophiles in subsequent cycloaddition processes via Sonogashira coupling of 3-(6-bromo-pyridin-2-yl)-[1,2,4]triazine scaffolds. The 41 examples explored during method development evaluated electrophile and nucleophile diversity affording the desired coupled products in 31-96% isolated yield. Method optimization, substrate scope, a scale-up reaction, and downstream product functionalization are reported herein. After reading the article, we found that the author used 2-Bromonicotinaldehyde(cas: 128071-75-0COA of Formula: C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. COA of Formula: C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2-BromonicotinaldehydeIn 2020 ,《Elemental Sulfur-Promoted [2+3+1] Annulation for Synthesis of Functionalized Thiochromeno[2,3-b]indoles from Indole Derivatives》 was published in Asian Journal of Organic Chemistry. The article was written by Liu, Jianming; Wang, Zhixian; Wang, Ke; Liu, Dong; Yang, Yan; Fan, Junjun; Zhuo, Kelei; Yue, Yuanyuan. The article contains the following contents:

An intermol. [2+3+1] annulation between indoles I (R1 = H, Me, OMe, Cl, Br; R2 = H, Me, F, OMe, Cl, Br; R3 = H, Me, Cl, F; R4 = H, OMe, Br, Cl) and aromatic aldehyde derivatives 2-Br-3-R5-4-R6-5-R7C6HCHO (R5 = H; R6 = H, Me; R7 = H, F, CF3; R5R6 = -CH=CH-CH=CH-) and 2-bromonicotinaldehyde was successfully achieved by utilizing elemental sulfur as the promoter and coupling partner. This direct and operationally simple procedure provided a rapid and reliable approach to synthesize functionalized thiochromeno[2,3-b]indoles II and pyrido[3′, 2′:5,6]thiopyrano[2, 3-b]indoles III. Preliminary mechanistic studies indicated that elemental sulfur enhanced the nucleophilicity of the 3-position of indole to attack an aldehyde group, and C-H cleavage of indole was not involved in the rate-determining step. The results came from multiple reactions, including the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Application In Synthesis of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Application In Synthesis of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

De Abreu, Maxime; Tang, Yue; Brachet, Etienne; Selkti, Mohamed; Michelet, Veronique; Belmont, Philippe published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Silver-catalyzed tandem cycloisomerization/hydroarylation reactions and mechanistic investigations for an efficient access to 1,2-dihydroisoquinolines》.Category: pyridine-derivatives The article contains the following contents:

An efficient silver-catalyzed tandem reaction for the formation of 1,2-dihydroisoquinoline derivatives is herein reported. Highly functionalized multiheterocyclic scaffolds are accessible in a straightforward manner using readily accessible starting materials under mild conditions. This methodol. offers an attractive route for the synthesis and development of a biol. relevant new heterocyclic pharmacophore, merging the biol. activities of isoquinolines with those of various nitrogen-containing heterocycles (indoles, pyrroles) incorporated during the tandem reaction. Mechanistic investigations were also conducted along with a large scope and limitation study, modifying various sites of this pharmacophore. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0Category: pyridine-derivatives)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Arai, Midori A.; Utsumi, Takao; Yanase, Natsuki; Fujimatsu, Teruhisa; Ishibashi, Masami published 《Efficient synthesis of heterocyclic flavonoids with hedgehog signal inhibitory activity》.Chemical & Pharmaceutical Bulletin published the findings.Safety of 2-Bromonicotinaldehyde The information in the text is summarized as follows:

A series of heterocyclic flavonoids I [R = 5-Br, 6-Br, 2-Br; R1 = H, 4-Me, 2-Br-4,5-(OCH3)2, 2-Br, etc.; X = OCH2OCH3, OH, OCH2OSi(CH3)2C(CH3)3] was evaluated for their Hh signaling inhibitory activity on cancer cell lines using our cell-based assay system. Among the synthetic flavonoids, compounds I (R = 5-Br, 2-Br; R1 = 2-Br; X = OCH2OCH3) showed good inhibitory activity (IC50 was 16.8 and 21.8 μM, resp.), and were cytotoxic toward human pancreatic (PANC1) and prostate (DU145) cancer cells in which Hh signaling was activated. Compounds I (R = 5-Br, 2-Br; R1 = 2-Br; X = OCH2OCH3) had moderate selectivity against PANC1 cells. Western blotting analyses revealed that PTCH and GLI1 expression was reduced after treatment with these compounds Overall, these synthetic flavonoids represent promising new additions to this expanding panel of Hh pathway inhibitors, and with further development these mols. may ultimately be considered for clin. use. In the experiment, the researchers used many compounds, for example, 2-Bromonicotinaldehyde(cas: 128071-75-0Safety of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Crowley, Vincent M.; Huard, Dustin J. E.; Lieberman, Raquel L.; Blagg, Brian S. J. published 《Second Generation Grp94-Selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer》.Chemistry – A European Journal published the findings.Synthetic Route of C6H4BrNO The information in the text is summarized as follows:

Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum (ER) resident isoform of the 90-kDa heat shock protein (Hsp90) family and its inhibition represents a promising therapeutic target for the treatment of many diseases. Modification of the first generation cis-amide bioisostere imidazole to alter the angle between the resorcinol ring and the benzyl side chain via cis-amide replacements produced compounds with improved Grp94 affinity and selectivity. Structure-activity relationship studies led to the discovery of compound 30 (Me 3-chloro-2-(2-(4-fluorobenzyl)phenethyl)-4,6-dihydroxybenzoate), which exhibits 540 nM affinity and 73-fold selectivity towards Grp94. Grp94 is responsible for the maturation and trafficking of proteins associated with cell signaling and motility, including select integrins. The Grp94-selective inhibitor 30 was shown to exhibit potent anti-migratory effects against multiple aggressive and metastatic cancers.2-Bromonicotinaldehyde(cas: 128071-75-0Synthetic Route of C6H4BrNO) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Synthetic Route of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Fu, Haiyan; Shen, Peng-Xiang; He, Jian; Zhang, Fanglin; Li, Suhua; Wang, Peng; Liu, Tao; Yu, Jin-Quan published 《Ligand-Enabled Alkynylation of C(sp3)-H Bonds with Palladium(II) Catalysts》.Angewandte Chemie, International Edition published the findings.HPLC of Formula: 128071-75-0 The information in the text is summarized as follows:

The palladium(II)-catalyzed β- and γ-alkynylation of amide C(sp3)-H bonds is enabled by pyridine-based ligands. This alkynylation reaction is compatible with substrates containing α-tertiary or α-quaternary carbon centers. The β-methylene C(sp3)-H bonds of various carbocyclic rings were also successfully alkynylated. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0HPLC of Formula: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.HPLC of Formula: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,European Journal of Organic Chemistry included an article by Tang, Shaojian; Wei, Wenjing; Yin, Dan; Poznik, Michal; Chruma, Jason J.. Application of 128071-75-0. The article was titled 《Palladium-Catalyzed Decarboxylative Generation and Propargylation of 2-Azaallyl Anions》. The information in the text is summarized as follows:

A palladium-catalyzed decarboxylative propargylation (DcPg) of propargyl 2,2-diphenylglycinate imines was developed for the synthesis of [((diphenylmethylene)amino)alkynyl]arenes (Ph2)C=NCH(Ar)CH2C≡CR [R = Me, Et, TMS; Ar = 4-CNC6H4, 2-BrC6H4, 3-pyridyl, etc.]. In this process, the nature of the propargyl ester and aryl imine components, as well as the catalyst system and solvent had a significant impact on the ratio of desired propargylated products vs. allene and/or diene side products that arose via different modes of C-C bond formation. The resulting propargylated products were transformed readily into useful (Z)-homoallylic amines. Moreover, the regioisomeric diene products could be converted to pharmaceutically-relevant diarylmethyl imines via a two-step Diels-Alder/oxidation process. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Application of 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application of 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem