Category: 128071-98-7

In an article, author is Matkovic, Silvana R., once mentioned the application of 128071-98-7, Quality Control of 4-Bromo-2-fluoropyridine, Name is 4-Bromo-2-fluoropyridine, molecular formula is C5H3BrFN, molecular weight is 175.99, MDL number is MFCD04112504, category is pyridine-derivatives. Now introduce a scientific discovery about this category.

Tailored Bronsted and Lewis surface acid sites of the phosphotungstic Wells Dawson heteropoly-acid

The synthesis of transition metals Wells Dawson heteropoly salts along with their elemental composition, water content, structure and specific surface area were thoroughly investigated. Additionally, the use of a molecular probe such as pyridine allowed the quantification of Lewis and Bronsted surface acid sites. The transition metals counter-cations provide both Lewis and Bronsted acid sites. The concentration of Bronsted acid sites is influenced by the crystallization water associated with the heteropoly anion. Additionally, the dispersion of the phosphotungstic Wells Dawson heteropolyacid over transition metal oxides evidenced the presence of both Bronsted and Lewis surface acid sites. The concentration of these sites is related to the surface dispersion of the crystals of the HPA over the oxide supports and the degree of hydration of the HPA.

If you are interested in 128071-98-7, you can contact me at any time and look forward to more communication. Quality Control of 4-Bromo-2-fluoropyridine.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Electric Literature of 128071-98-7, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 128071-98-7, Name is 4-Bromo-2-fluoropyridine, SMILES is C1=CN=C(C=C1Br)F, belongs to pyridine-derivatives compound. In a article, author is Sergienko, V. S., introduce new discover of the category.

Molecular and Inner Complex Compounds of Dioxomolybdenum(VI) with Disubstituted Salicydenealcoholimines: Crystal Structure of 1: 1 Dioxo(3,5-Dibromosalicylidenemonoethanoliminato)molybdenum(VI) Solvate with Methanol [MoO2(L-1) center dot MeOH] (L-1 = C9H7Br2NO2)

Complexes of dioxomolybdenum(VI) of the molecular (MoO2Cl2 center dot 2H(2)L) and inner complex ([MoO2L center dot Solv]) types are synthesized (H2L are azomethines, derivatives of disubstituted R-1,R-2-salicylaldehydes (R-1, R-2 = 3.5-Br-2; R-1 = 3-MeO, R-2 = 5-Br) and monoethanolamine; Solv is a methanol, dimethylformamide, pyridine, or a-picoline molecule). The cis-octahedral structure of the complexes is concluded on the basis of the IR spectroscopic data. In the molecular compounds, the ligands are coordinated via the O atom of the carbonyl group of the H2L tautomeric form. In the inner complex compounds, the ligands are coordinated in the deprotonated benzoid form. The structure of [MoO2(L-1) center dot MeOH] (I) (where L-1 is C9H7Br2NO2) is determined by X-ray diffraction analysis (CIF file CCDC no. 1898088). In the mononuclear molecule of compound I, the Mo atom has the octahedral coordination by two oxo ligands, two oxygen atoms, the nitrogen atom of the tridentate bis(chelate) two-charge ligand (L-1)(2-), and the O atom of the methanol molecule. The neutral N(1) and O(1) atoms of the L-1 and MeOH ligands, respectively, are arranged in the trans positions to the O(oxo) ligands. The Mo-N(1) (2.265 angstrom) and Mo-O(1) (2.372 angstrom) bonds are substantially elongated due to the structural manifestation of the trans effect of the multiply bonded oxo ligands. The intermolecular hydrogen bonds (MeOH)O-H center dot center dot center dot O(oxo) join the molecules into supramolecular 1D chains.

Electric Literature of 128071-98-7, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 128071-98-7.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Electric Literature of 128071-98-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 128071-98-7, name is 4-Bromo-2-fluoropyridine. A new synthetic method of this compound is introduced below.

To a solution of LDA (2.0 M solution in THF) (12.79 mL, 25.6 mmol) in THF (20 mL) was added a solution of 4-bromo-2-fluoropyridine (3.0 g, 17.05 mmol) in THF (5 mL) dropwise at -78 C. The reaction mixture was stirred at-78 C for 1 h, then methyl iodide (1.599 mL, 25.6 mmol) was added. The reaction mixture was stirred at -78 C for 30 min, then stirred at rt for 0.2 h. The reaction mixture was diluted with water and the resulting mixture was extracted with ethyl acetate. The organic layer was separated and washed with brine, dried over MgSCk The filtrate was concentrated in vacuo. (0531) The residue was dissolved in DCM, purified via silica gel flash column chromatography, eluting with 0-15% ethyl acetate in hexane to give Intermediate 27A (colorless oil, 2.3 g, 12.1 mmol, 71% yield). LC-MS Anal. Calc’d for CeHsBrFN 188.96, found [M+H] 190, 192.1. Tr = 0.83 min (Method A). NMR (400MHz, DMSO-de) delta 7.97 (d, J=5.4 Hz, 1H), 7.63 (d, J=5.4 Hz, 1H), 2.30 – 2.29 (m, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,128071-98-7, 4-Bromo-2-fluoropyridine, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; CHERNEY, Emily Charlotte; ZHANG, Liping; HUANG, Audris; SHAN, Weifang; WILLIAMS, David K.; ZHU, Xiao; GUO, Weiwei; (213 pag.)WO2018/209049; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 128071-98-7 ,Some common heterocyclic compound, 128071-98-7, molecular formula is C5H3BrFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of 4-bromo-2-fluoropyridine (528 mg, 3 mmol), phenylboronic acid (399 mg, 3.3 mmol), Pd(PPFi3)4(69 mg, 0.06 mmol) in toluene/ethanol (4:1, 25 ml) was added a solution of Na2C03 (1.27 g, 12 mmol) in water (10 ml). The resulting yellow solution was stirred at 80 C for 2 hours, during which time the solution turned black. After cooling to ambient temperature the reaction mixture was extracted with EtOAc (3 x 50 ml). The combined organic layers were the washed with brine (50 ml), dried over MgS04, filtered and concentrated in vacuo. The crude product was purified by hot filtration from MeOH followed by silica gel chromatography (5% EtOAc in n-pentane) to the title compound as a light yellow solid (490 mg, 2.8 mmol, 94%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 128071-98-7, 4-Bromo-2-fluoropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ANDREN, Per; ODELL, Luke; NILSSON, Anna; SHARIATGORJI, Mohammadreza; SAeVMARKER, Jonas; (0 pag.)WO2019/172830; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem