Synthetic Route of 128073-09-6, Adding some certain compound to certain chemical reactions, such as: 128073-09-6, name is 3-Chloro-5-methoxypicolinic acid,molecular formula is C7H6ClNO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 128073-09-6.
Example 169 Synthesis of N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-3-chloro-5-methoxypicolinamide The titled compound was synthesized by procedure and steps analogous to those described in Method Y, Example 163 above, but using 3-chloro-5-methoxypicolinic acid (intermediate 27) in step 10. MS m/z=478.9 [M+H]+. Calculated for C19H16ClF5N4O3: 478.8 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1.65 (s, 3H) 1.91 (t, J=13.11 Hz, 1H) 2.79 (d, J=12.91 Hz, 1H) 3.95 (s, 3H) 4.05 (br. s., 1H) 6.99 (br. s., 1H) 7.32 (br. s., 1H) 8.18 (br. s., 2H) 9.86 (br. s., 1H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 128073-09-6, 3-Chloro-5-methoxypicolinic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MINATTI, Ana Elena; LOW, Jonathan D.; ALLEN, Jennifer R.; CHEN, Jian; CHEN, Ning; CHENG, Yuan; JUDD, Ted; LIU, Qingyian; LOPEZ, Patricia; QIAN, Wenyuan; RUMFELT, Shannon; RZASA, Robert M.; TAMAYO, Nuria A.; XUE, Qiufen; YANG, Bryant; ZHONG, Wenge; US2014/249104; (2014); A1;,
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