Category: 130721-78-7

Synthetic Route of 130721-78-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 130721-78-7, name is tert-Butyl (4-chloropyridin-2-yl)carbamate. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a – 78Csolution of N-Boc-2-amino-4-chloropyridine(3.6g, 15.8 mmol) and TMEDA (3.7 g, 31.2 mmol) in anhydrous THF (67 mL) wasadded dropwise a 1.3 M solution of n-BuLiin hexane (25 mL, 31.2 mmol). The reaction mixture was stirred at -78C during 1hand then a solution of I2 (8.0 g, 31.2 mmol) inTHF (27 mL) was added dropwise. Temperature was allowed to rise at roomtemperature during 1h and the reaction mixure was hydrolized with a saturatedsolution of ammonium chloride (30 mL) and extracted with EtOAc (3 x 30 mL). Thecombined organic phases were washed with a 10% solution of Na2S2O3(30 mL), brine (30 mL), dried over MgSO4, filtered and concentrated under reduced pressure. The iodinated aminopyridine was obtained as a beigesolid (4.2 g, 76%) without further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 130721-78-7, tert-Butyl (4-chloropyridin-2-yl)carbamate.

Reference:
Article; Silpa, Laurence; Niepceron, Alisson; Laurent, Fabrice; Brossier, Fabien; Penichon, Melanie; Enguehard-Gueiffier, Cecile; Abarbri, Mohamed; Silvestre, Anne; Petrignet, Julien; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 114 – 120;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.130721-78-7, name is tert-Butyl (4-chloropyridin-2-yl)carbamate, molecular formula is C10H13ClN2O2, molecular weight is 228.68, as common compound, the synthetic route is as follows.Formula: C10H13ClN2O2

To a stirred solution of compound 5-(5- chloro-2-fluorophenyl)-6-methoxy-N2,N2-dimethylpyridine-2, 3-diamine (0.5 g, 1.69 mmol, 1.0 eq) and tert-butyl (4-chloropyridin-2-yl)carbamate (0.463 g, 2.02 mmol, 1.2 eq) in dioxane (20 mL) was added Cs2C03 (2.20 g, 6.76 mmol, 4.0 eq) at rt. The resulting mixture was purged with nitrogen for 10 min followed by addition of Pd2(dba)3 (0.185 g, 0.20 mmol, 0.12 eq) and xantphos (0.146 g, 0.25 mmol, 0.15 eq), again purged with nitrogen for 10 min. The reaction mixture was heated at l30C for 48 h. The progress of reaction was monitored by LCMS. The reaction mixture was filtered through celite, the residue was washed with EtOAc (10 mL). The filtrate was concentrated and purified by combi flash chromatography [silica gel 100-200 mesh; elution 0-10 MeOH in DCM] to afford the desired compound (150 mg, 22.83%) as brown solid. LCMS: (M+l)+ 388.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,130721-78-7, tert-Butyl (4-chloropyridin-2-yl)carbamate, and friends who are interested can also refer to it.

Reference:
Patent; INTEGRAL BIOSCIENCES PVT. LTD.; PUJALA, Brahmam; PENDHARKAR, Dhananjay; AGARWAL, Anil Kumar; KUMAR, Varun; ARYA, Satish Kumar; CHAKRAVARTY, Sarvajit; (0 pag.)WO2020/12357; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem