Category: 130722-95-1

Application of 130722-95-1, Adding some certain compound to certain chemical reactions, such as: 130722-95-1, name is 3-(Benzyloxy)-5-bromopyridine,molecular formula is C12H10BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 130722-95-1.

3-Benzyloxy-5-bromopyridine (4.73 g, 18.0 mmol) was dissolved in tetrahydrofuran (25 rnL) and cooled to 0 0C.Isopropylmagnesiumchloride (10 mL, 2.0 M in THF) was syringed in and the reaction mixture was stirred for 2 hrs at room temperature. N.N-dimethylformamide (3 mL) in tetrahydrofuran (10 mL) was added and stirring was continued for an additional hour. The solution was quenched with 2 N HCl to pH of 3 then partitioned between ethyl acetate and water. The organic layer was separated and concentrated to give a residue which was purified using flash chromatography to give 3-benzyloxy-5-formylpyridine (2.00 g, 53%) as white solid. 1H NMR (DMSO-^6): delta 10.1 (s, IH), 8.72 (d, IH), 8.66 (d, IH), 7.84 (m, IH), 7.42-7.48 (m, 5H), 5.28 (s, 2H).

According to the analysis of related databases, 130722-95-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; WO2007/84560; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 130722-95-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 130722-95-1, name is 3-(Benzyloxy)-5-bromopyridine. This compound has unique chemical properties. The synthetic route is as follows.

10d. 3-amino-5-benzyloxypyridine The product of Example 10c above (41.3 g 156 mmol), copper(I) bromide (22.43 g 156 mmol), MeOH (275 mL), and liquid NH3 (50 mL) were combined in a stainless steel reactor and heated to 130 C. for 24 hours. The mixture was allowed to cool to ambient temperature, then concentrated. The residue was suspended in 300 mL of saturated aqueous Na2 CO3 and extracted with CH2 Cl2. The combined CH2 Cl2 solutions were washed with brine, dried (MgSO4), and concentrated. The crude product was chromatographed (silica gel; hexane/EtOAc, 9:1 to 7:3) to afford the title compound (15.6 g, 50%): 1 H NMR (CDCl3, 300 MHz) delta: 8.21-8.29 (m, 2H), 7.44-1.26 (m, 6H), 5.10 (s, 2H); MS (CI/NH3) m/z 201 (M+H)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 130722-95-1, 3-(Benzyloxy)-5-bromopyridine.

Reference:
Patent; Abbott Laboratories; US6133253; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 130722-95-1, Adding some certain compound to certain chemical reactions, such as: 130722-95-1, name is 3-(Benzyloxy)-5-bromopyridine,molecular formula is C12H10BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 130722-95-1.

3-Benzyloxy-5-bromopyridine (15.0 g, 56.8 mmol), prepared as described in (US 5,733,912), and 30% HBr/acetic acid (200 mL) were stirred at ambient temperature for 16 hours. The reaction was diluted with diethyl ether (500 mL) and the resulting white solid (12.9 g) was isolated by filtration. The solid was taken up in methanol (300 mL) and concentrated NH4OH (50 mL) was added. After stirring at ambient temperature for 12 hours, the mixture was concentrated under reduced pressure to provide the title compound as a white solid (9.8 g, 89%). MS (DCI/NH3) m/z 174/176 (M+H)+.

According to the analysis of related databases, 130722-95-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ABBOTT LABORATORIES; EP1428824; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 130722-95-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 130722-95-1, name is 3-(Benzyloxy)-5-bromopyridine. A new synthetic method of this compound is introduced below.

To a stirred solution of 3-(benzyloxy)-5-bromopyridine (1 g, 3.7 mmol) in toluene (25 mL), were added tris(dibenzylideneacetone)dipalladium(0) (169 mg, 0.185 mmol), 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (230 mg, 0.37 mmol) and sodium tert-butoxide (710 mg, 7.4) and the flask was purged with argon. Thiomorpholine 1,1-dioxide (766 mg, 5.68) was added to the mixture and heated to 80 oC for 14 hours. After the completion of the reaction (monitored by TLC) the solvent was removed under vacuum. Water was added (10 mL) and the mixture was extracted with ethyl acetate (3×30 mL). The combined organic layer was dried over Na2SO4 and concentrated under reduced pressure. The residue was purified on silica gel (Biotage; eluting solvents DCM: MeOH 10/1 ratio) to obtain red oil (720 mg, 60% yield); 1H NMR (500 MHz, CDCl3) delta 7.96 (m, 2H), 7.41-7.34 (m, 5H), 6.75 (t, J = 2.2 Hz, 1H), 5.10 (s, 2H), 3.85 – 3.83 (m, 4H), 3.08 – 3.06 (m, 4H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,130722-95-1, 3-(Benzyloxy)-5-bromopyridine, and friends who are interested can also refer to it.

Reference:
Article; Lamani, Manjunath; Malamas, Michael S.; Farah, Shrouq I.; Shukla, Vidyanand G.; Almeida, Michael F.; Weerts, Catherine M.; Anderson, Joseph; Wood, JodiAnne T.; Farizatto, Karen L.G.; Bahr, Ben A.; Makriyannis, Alexandros; Bioorganic and Medicinal Chemistry; vol. 27; 23; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem