Category: 131747-42-7

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 131747-42-7, name is 6-(Trifluoromethyl)picolinic acid. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 6-(Trifluoromethyl)picolinic acid

6-Trifluoromethylpyridine-2-carboxylic acid (25 g, 130.8 mmol) was dissolved in 300 mL of methanol, and thionyl chloride (23.3 g, 196.2 mmol) was added dropwise. After addition, the mixture was refluxed for reaction for 12 h. The resultant solution was concentrated untill dry, and saturated sodium hydrogen carbonate solution was added to adjust the pH, and then the resultant was extracted with ethyl acetate, dried over anhydrous sodium sulfate to give the title compound.

With the rapid development of chemical substances, we look forward to future research findings about 131747-42-7.

Reference:
Patent; Nanjing Sanhome Pharmaceutical Co., Ltd.; WANG, Yong; ZHAO, Liwen; LIU, Xiaorong; ZHANG, Yan; HUANG, Dandan; JIANG, Chunhuan; SHI, Xinsheng; GU, Hongfeng; PANG, Silin; HAI, Wei; GE, Bingyang; (71 pag.)EP3489230; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 131747-42-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 131747-42-7, name is 6-(Trifluoromethyl)picolinic acid. This compound has unique chemical properties. The synthetic route is as follows.

Methanol was added to the reaction vessel under nitrogen atmosphere. 6-trifluoromethyl-pyridine-2-carboxylic acid (150 g, 0.785 mol) was added and dissolved at ambient temperature. Acetyl chloride (67.78 g, 0.863 mol) was added dropwise at a temperature below 45C. The reaction mixture was maintained at 65-70C for about 2-2.5 h, and then concentrated at 3 5-45C under vacuum and cooled to 25-35C. The mixture was diluted with ethyl acetate and rinsed with saturated NaHCO3 solution then rinsed with brine solution. The mixture was concentrated at 3 5-45C under vacuum and cooled to 25-35C, then rinsed with nheptane and concentrated at 3 5-45C under vacuum, then degassed to obtain brown solid, which was rinsed with n-heptane and stirred for 10-15 minute at 25-35C. The suspension was cooled to -40 to -3 0C while stirring, and filtered and dried to provide 6-trifluoromethyl-pyridine-2- carboxylic acid methyl ester.

According to the analysis of related databases, 131747-42-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CELGENE CORPORATION; AGIOS PHARMACEUTICALS, INC.; CHOPRA, Vivek, Saroj, Kumar; DIMARTINO, Jorge; KENVIN, Laurie, A.; KNIGHT, Robert, Douglas; MACBETH, Kyle; VISWANADHAN, Krishnan; XU, Qiang; AGRESTA, Samuel, V.; (135 pag.)WO2017/66611; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem