131747-43-8 | Pyridine-derivatives

26-Sep News Introduction of a new synthetic route about 131747-43-8

With the rapid development of chemical substances, we look forward to future research findings about 131747-43-8.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 131747-43-8, name is 2-Trifluoromethylnicotinic acid, molecular formula is C7H4F3NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 131747-43-8

2- [2-Chloro-4- [4- [3-chloro-5- (trifluoromethyl) pyridin-2-yloxy] phenylethynyl] phenyl-2,2-difluoro-1-methylethylamine 104 mg N, N -In a 2 ml solution of dimethylformamide, 65 mg of triethylamine, 5 mg of 4- (N, N-dimethylamino) pyridine and O- (benzotriazol-1-yl) -N, N, N ‘, N’-tetramethyluronium tetrafluoroborate 82 mg of lato, 3 mg of 4- (N, N-dimethylamino) pyridine and 49 mg of 2- (trifluoromethyl) nicotinic acid were added and stirred at room temperature for 12 hours. After completion of the reaction, 3 ml of water was added and extracted with ethyl acetate (5 ml × 1). The organic layer was dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel chromatography eluting with ethyl acetate-hexane (gradient from 0:10 to 2: 8) to obtain 77 mg of the objective product as a colorless dendritic substance.

With the rapid development of chemical substances, we look forward to future research findings about 131747-43-8.

Reference:
Patent; Nissan Chemical Co., Ltd.; Iwasa, Motoyoshi; Yoshinaga, Yutaka; Mitsumori, Norihiko; Asahi, Miho; Uemura, Yuki; (97 pag.)JP2019/151593; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

26-Sep News Introduction of a new synthetic route about 131747-43-8

With the rapid development of chemical substances, we look forward to future research findings about 131747-43-8.

6 Sep 2021 News Analyzing the synthesis route of 131747-43-8

Statistics shows that 131747-43-8 is playing an increasingly important role. we look forward to future research findings about 2-Trifluoromethylnicotinic acid.

Related Products of 131747-43-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.131747-43-8, name is 2-Trifluoromethylnicotinic acid, molecular formula is C7H4F3NO2, molecular weight is 191.11, as common compound, the synthetic route is as follows.

Step 5: ?-??1 -(4-chlorothiazol-2-yl)cvclopropyllmethyll-2-(trifluoromethyl)pyridine-3- carboxamide (Compound A21 )To a solution of [1-(4-chlorothiazol-2-yl)cyclopropyl]methanamine (0.153 g, 0.747 mmol) in dry dichloromethane (3.0 mL) was added, under argon, NEt3 (0.210 ml_, 1 .49 mmol), then the mixture was cooled down to 0C. HOBT H20 (0.204 g, 1 .49 mmol), EDC HCL (0.287 g, 1.49 mmol), and 2-(trifluoromethyl)pyridine-3-carboxylic acid (0.143 g, 0.747 mmol,) were successively added and the reaction mixture was stirred 3h. at R.T. Water was added, the aqueous solution was extracted with dichloromethane (3 times), the combined organic layers were washed by NaCI, dried over Na2S04, filtrated and evaporated under reduced pressure. A white solid was obtained (387 mg). It was purified by flash chromatography (Cyclohexane to Cyclohexane/AcOEt :1/1 ) to afford the desired product as a white solid (102 mg).1H-NMR (CDCI3): 8.77 (dd, 1 H), 7.92 (dd, 1 H), 7.56 (dd, 1 H), 6.97 (bs, 1 H), 6.9 (s, 1 H), 3.86 (d, 2H), 1.42 (m, 2H), 1.18 (m, 2H).

Statistics shows that 131747-43-8 is playing an increasingly important role. we look forward to future research findings about 2-Trifluoromethylnicotinic acid.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; LOISELEUR, Olivier; PITTERNA, Thomas; O’SULLIVAN, Anthony, Cornelius; LUKSCH, Torsten; WO2013/64518; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The origin of a common compound about 131747-43-8

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 131747-43-8, 2-Trifluoromethylnicotinic acid, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 131747-43-8 ,Some common heterocyclic compound, 131747-43-8, molecular formula is C7H4F3NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 64. a) To a stirred solution of 2-trifiuoromethyl nicotinic acid (0.38 g, 2 mmol) in dimethylformamide (10 mL) at room temperature was added 1,1-carbonyldiimidazole (0.34 g, 2.10 mmol) in one portion. The resulting yellow mixture was allowed to stir for ninety minutes whereupon 3,4-bis(benzyloxy)-N’-hydroxy-5-nitrobenzamidine (0.79 g, 2 mmol) was added in one portion. The resulting mixture was stirred at room temperature for two hours and then poured onto water (100 mL). The resulting precipitate was filtered off, washed with water and dried. After recrystallisation from dichloromethane/isopropanol 3 ,4-bis(benzyloxy)-5-nitro-N’-(2- (trifluoromethyl)nicotinoyloxy)benzimidamide was obtained, as a light yellow solid, 0.88 g (78%).

Reference:
Patent; PORTELA & CA. S.A.; WO2007/13830; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The origin of a common compound about 2-Trifluoromethylnicotinic acid

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,131747-43-8, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 131747-43-8, 2-Trifluoromethylnicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 131747-43-8, blongs to pyridine-derivatives compound. COA of Formula: C7H4F3NO2

Alternate coupling procedure:Combine 4-(4,5-dimethyl-6-(4-(methylamino)piperidin-l-yl)pyridazin-3- yl)benzonitrile (300 mg, 0.93 mmol), 2-(trifluoromethyl)nicotinic acid (210 mg, 1.12 mmol) and diisopropylethylamine (0.79 mL, 4.51 mmol) in a 4: 1 mixture of DMF and DMSO (20 mL). Heat the mixture briefly at 60 0C to dissolve the solids, and then cool to 0 0C. Add a solution of perfluorophenyl diphenylphosphinate (750 mg, 1.96 mmol) in a 4: 1 mixture of DMF and DMSO (1 mL) dropwise. Heat the resulting mixture at 60 0C overnight. Partition the reaction mixture between aqueous NaHCO3 solution and CH2Cl2. Wash the organic layer with brine, dry over Na2SO4, filter, and concentrate under reduced pressure. Purify the resulting residue by flash silica gel chromatography (20:5: 1 hexanes: EtOAc: 2 M NH3/MeOH) to provide the free base of the title compound (346 mg, 75%). ES/MS m/z 495.2 (M+l). Form the HCl salt as described above.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,131747-43-8, its application will become more common.

Reference:
Patent; ELI LILLY AND COMPANY; BASTIAN, Jolie, Anne; CLAY, Julia, Marie; COHEN, Jeffrey, Daniel; HIPSKIND, Philip, Arthur; LOBB, Karen, Lynn; SALL, Daniel, Jon; WILSON (NEE TAKAKUWA), Takako; THOMPSON, Michelle, Lee; WO2010/56588; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem