Category: 131747-45-0

Mn(II) tags for DEER distance measurements in proteins via C-S attachment was written by Martorana, Andrea;Yang, Yin;Zhao, Yu;Li, Qing-Feng;Su, Xun-Cheng;Goldfarb, Daniella. And the article was included in Dalton Transactions in 2015.Category: pyridine-derivatives This article mentions the following:

Mn²⁺ chelating tags for Mn²⁺-Mn²⁺ distance measurements by pulse EPR spectroscopy were developed. They feature a stable C-S conjugation to the protein, high reactivity towards cysteine thiols and short and rigid linkers that can be used in distance measurements with high resolution under reductive conditions. Double electron-electron resonance measurements at 95 GHz on ubiquitin labeled with these tags showed the expected narrow distance distribution. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Category: pyridine-derivatives).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Solvent polarity and oxygen sensitivity, rather than viscosity, determine lifetimes of biaryl-sensitised terbium luminescence was written by Walter, Edward R. H.;Williams, J. A. Gareth;Parker, David. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Quality Control of (4-Bromopyridin-2-yl)methanol This article mentions the following:

In a macrocyclic terbium complex incorporating a biaryl sensitizer, the observed variation of emission lifetime is shown to be determined by the solubility of oxygen in the solvent system and the relative energy of the chromophore excited state, rather than any dependence on solvent viscosity. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Quality Control of (4-Bromopyridin-2-yl)methanol).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Quality Control of (4-Bromopyridin-2-yl)methanol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824) was written by Kmentova, Iveta;Sutherland, Hamish S.;Palmer, Brian D.;Blaser, Adrian;Franzblau, Scott G.;Wan, Baojie;Wang, Yuehong;Ma, Zhenkun;Denny, William A.;Thompson, Andrew M.. And the article was included in Journal of Medicinal Chemistry in 2010.Formula: C6H6BrNO This article mentions the following:

New heterocyclic analogs of the potent biphenyl class derived from antitubercular drug I were prepared, aiming to improve aqueous solubility but maintain high metabolic stability and efficacy. The strategy involved replacement of one or both Ph groups by pyridine, pyridazine, pyrazine, or pyrimidine, in order to reduce lipophilicity. For para-linked biaryls, hydrophilicities (ClogP) correlated with measured solubilities, but highly soluble bipyridine analogs displayed weak antitubercular activities. A terminal pyridine or proximal heterocycle allowed retention of potency and provided solubility improvements, particularly at low pH, with examples from the latter classes displaying the better in vivo efficacies, high metabolic stabilities, and excellent pharmacokinetics. Five such compounds were >100-fold better than the parent drug in a mouse model of acute Mycobacterium tuberculosis infection, and two orally bioavailable pyridine analogs (3-4-fold more soluble than the parent at low pH) were superior to antitubercular drug II in a chronic infection model. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Formula: C6H6BrNO).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C6H6BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Novel 1,4-dihydropyridine calcium antagonists. I. Synthesis and hypotensive activity of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives was written by Ashimori, Atsuyuki;Ono, Taizo;Uchida, Takeshi;Ohtaki, Yutaka;Fukaya, Chikara;Watanabe, Masahiro;Yokoyama, Kazumasa. And the article was included in Chemical & Pharmaceutical Bulletin in 1990.Recommanded Product: (4-Bromopyridin-2-yl)methanol This article mentions the following:

A series of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives I (R = H, halo, CF₃, etc.) were synthesized and their hypotensive effects examined Several compounds have a hypotensive activity parallel to that of nicardipine; the 4-(3-trifluoromethyl-2-pyridyl) and 4-(2-trifluoromethyl-3-pyridyl) derivatives, in particular, had approx. twice the duration of nicardipine, and the 4-(4-cyano-2-pyridyl) derivative had the most potent hypotensive activity of all the derivatives synthesized. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Recommanded Product: (4-Bromopyridin-2-yl)methanol).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ路mol鈭? in pyridine vs. 150 kJ路mol鈭? in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: (4-Bromopyridin-2-yl)methanol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Selectively switching on europium emission in drug site one of human serum albumin was written by Shuvaev, Sergey;Pal, Robert;Parker, David. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Computed Properties of C6H6BrNO This article mentions the following:

A luminescent europium probe has been discovered that binds selectively to drug-site I in human serum albumin, signaled by a switching on of europium emission and accompanied by strong induced circularly polarized luminescence. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Computed Properties of C6H6BrNO).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Computed Properties of C6H6BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Crystal Structures and Magnetic Properties of Complexes of M^IICl₂ (M = Cu, Ni, and Co) Coordinated with 4-(N-tert-butyloxyamino)-2-(methoxymethylenyl)pyridine: 2D Magnetic Anisotropy of the Aminoxyl-Co^II Complex in the Crystalline State was written by Zhu, Zhicheng;Karasawa, Satoru;Koga, Noboru. And the article was included in Inorganic Chemistry in 2005.Application of 131747-45-0 This article mentions the following:

Three metal complexes, [M^IICl₂(4NOPy-OMe)₂] (M = Cu (1), Ni (2), and Co (3)), were prepared by mixing the corresponding metal chloride and aminoxyl radical 4-(N-tert-butyloxyamino)-2-(methoxymethylenyl)pyridine, 4NOPy-OMe, in 1:2 ratio. Complex 1 has two structures (complexes A and B) with similar coordination geometries, compressed octahedrons. In the crystal structure, complexes A and B locate alternately in short distances (C_radical··· C_β = 3.17 and 3.23 Å) to form a 1-dimensional chain structure. Complexes 2 and 3 are isomorphous and have a slightly distorted octahedral structure. In the crystal structure, both complexes have intermol. short contacts (C_radical···C_α = 3.46 and 3.52 Å for 2 and 3, resp.) to form the 2-dimensional structures. The temperature dependence of the χ_molT values for the three complexes indicated that the magnetic interactions between the radicals and the metal ions within the complexes were ferromagnetic. By fitting a modified Fisher 1-dimensional model to the data of the χ_molT vs. T plot for 1, the authors estimated the intra- and intermol. (intrachain) exchange coupling constants to be J₁/k_B = 60.2 and J₂/k_B = -7.02 K, resp. However, complexes 2 and 3 showed steep increases of the χ_molT value below ca. 3 K, indicating that the long-range magnetic ordering is operating. The 1/χ_mol vs. T plot for 2 was analyzed by a Curie-Weiss model to give θ = 6.25 K and C = 2.02 cm³ K mol^-1 with g_Ni = 2.25. Complex 3 was studied in more detail using an oriented sample. Magnetic behavior strongly depends on the direction of the applied field, in which the c^* axis perpendicular to the ab plane is an easy axis for magnetization. D.c. and a.c. magnetic susceptibility measurements revealed that complex 3 had a magnetic phase transition of T_c = 2.14 K and exhibited a glass-like magnetic behavior below T_c. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Application of 131747-45-0).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application of 131747-45-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reaction-Based Europium Complex for Specific Detection of Cysteine Over Homocysteine and Glutathione with Variable-Temperature Kinetic Studies was written by Yip, Yuk-Wang;Yan, Zhiyuan;Law, Ga-Lai;Wong, Wing-Tak. And the article was included in European Journal of Inorganic Chemistry in 2019.Reference of 131747-45-0 This article mentions the following:

A water-soluble europium(III)-based probe, EuL, has been designed and synthesized for selective recognition of cysteine (Cys) over other structurally similar thiols and amino derivatives due to formation of a more stable and preferable seven-membered ring. Addition of Cys shows a significant response with quenching of over 90% of the initial signal (Hcys: 10.5%, GSH: 3.6% resp.). A good linear correlation between the emission intensities and concentrations of Cys has been established. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Reference of 131747-45-0).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Reference of 131747-45-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Novel 1,4-dihydropyridine calcium antagonists. I. Synthesis and hypotensive activity of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives was written by Ashimori, Atsuyuki;Ono, Taizo;Uchida, Takeshi;Ohtaki, Yutaka;Fukaya, Chikara;Watanabe, Masahiro;Yokoyama, Kazumasa. And the article was included in Chemical & Pharmaceutical Bulletin in 1990.Recommanded Product: (4-Bromopyridin-2-yl)methanol This article mentions the following:

A series of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives I (R = H, halo, CF₃, etc.) were synthesized and their hypotensive effects examined Several compounds have a hypotensive activity parallel to that of nicardipine; the 4-(3-trifluoromethyl-2-pyridyl) and 4-(2-trifluoromethyl-3-pyridyl) derivatives, in particular, had approx. twice the duration of nicardipine, and the 4-(4-cyano-2-pyridyl) derivative had the most potent hypotensive activity of all the derivatives synthesized. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Recommanded Product: (4-Bromopyridin-2-yl)methanol).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: (4-Bromopyridin-2-yl)methanol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A highly selective on-off-on responsive lanthanide(III) based probe for recognition of copper and hydrogen sulfide was written by Yip, Yuk-Wang;Law, Ga-Lai;Wong, Wing-Tak. And the article was included in Dalton Transactions in 2016.Application In Synthesis of (4-Bromopyridin-2-yl)methanol This article mentions the following:

The development of a europium(III) based probe (EuL1) for the detection of Cu(II) ions and hydrogen sulfide is presented. With the addition of Cu(II) ions, EuL1 displayed the greatest quenching among the other cations examined The binding constant was 74 026 ± 2899 M^-1. Once combined with Cu(II) ions, EuL1Cu demonstrated high specificity for hydrogen sulfide compared to other organic and inorganic sulfur compounds EuL1Cu exhibited an on-off-on type luminescence change with the alternate addition of Cu(II) ions and H₂S along with reversible forming-separating of the complex. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Application In Synthesis of (4-Bromopyridin-2-yl)methanol).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of (4-Bromopyridin-2-yl)methanol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A highly selective on-off-on responsive lanthanide(III) based probe for recognition of copper and hydrogen sulfide was written by Yip, Yuk-Wang;Law, Ga-Lai;Wong, Wing-Tak. And the article was included in Dalton Transactions in 2016.Application In Synthesis of (4-Bromopyridin-2-yl)methanol This article mentions the following:

The development of a europium(III) based probe (EuL1) for the detection of Cu(II) ions and hydrogen sulfide is presented. With the addition of Cu(II) ions, EuL1 displayed the greatest quenching among the other cations examined The binding constant was 74 026 ± 2899 M^-1. Once combined with Cu(II) ions, EuL1Cu demonstrated high specificity for hydrogen sulfide compared to other organic and inorganic sulfur compounds EuL1Cu exhibited an on-off-on type luminescence change with the alternate addition of Cu(II) ions and H₂S along with reversible forming-separating of the complex. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Application In Synthesis of (4-Bromopyridin-2-yl)methanol).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of (4-Bromopyridin-2-yl)methanol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem