Category: 131747-55-2

Huang, Qi; Zard, Samir Z. published the artcile< Modular route to azaindanes>, Electric Literature of 131747-55-2, the main research area is xanthate ester radical cyclization; azaindane preparation.

A convergent radical based route to azaindanes, e.g., I, is described, relying on the degenerative addition transfer of various substituted S-(pyridylmethyl)-O-Et dithiocarbonates (xanthates) to functional alkenes followed by radical cyclization onto the pyridine ring activated by protonation with trifluoroacetic acid. In one case, a richly decorated cyclohepta[b]pyridine could be assembled swiftly by allowing the first adduct to N-phenylmaleimide to undergo addition to N-allylphthalimide prior to cyclization.

Organic Letters published new progress about Heterocyclic compounds Role: SPN (Synthetic Preparation), PREP (Preparation) (azaindanes). 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Electric Literature of 131747-55-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Liang; Zhang, Wenpeng; Lin, Feng; Lu, Xinqiang; Chen, Wei; Li, Xingzhou; Zhou, Xinbo; Su, Ruibin; Wang, Lili; Zheng, Zhibing; Li, Song published the artcile< Synthesis and biological evaluation of pyrazolo[3,4-b]pyridine-3-yl pyrimidine derivatives as sGC stimulators for the treatment of pulmonary hypertension>, Application In Synthesis of 131747-55-2, the main research area is pyrazolopyridinyl pyrimidine preparation sGC stimulator; Pulmonary hypertension; Riociguat; pyrazolo[3,4-b]pyridine-3-yl pyrimidine derivatives; sGC stimulators.

A series of new pyrazolo[3,4-b]pyridin-3-yl pyrimidine derivatives I [R = 2-thiophenyl, 3-fluorothiophen-2-yl, 5-methylpyridin-3-yl; R1 = Me, Et, i-Pr; R2 = Me, Et] were synthesized and evaluated for the activation of sGC. Compared with riociguat, compound I [R = 3-fluorothiophen-2-yl; R1 = R2 = Me] exhibited equivalent in vitro activity on preconstricted rat thoracic aorta rings and in Rat heart Langendorff preparation Compound I [R = 3-fluorothiophen-2-yl; R1 = R2 = Me] also showed acceptable PK profiles, which might become a promising candidate for the treatment of pulmonary hypertension.

European Journal of Medicinal Chemistry published new progress about Pulmonary hypertension. 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Application In Synthesis of 131747-55-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lenstra, Danny C.; Lenting, Peter E.; Mecinovic, Jasmin published the artcile< Sustainable organophosphorus-catalysed Staudinger reduction>, Name: 2-Fluoro-3-(hydroxymethyl)pyridine, the main research area is amine green preparation; azide Staudinger reduction.

A highly efficient and sustainable catalytic Staudinger reduction for the conversion of organic azides to amines in excellent yields was developed. The reaction displayed excellent functional group tolerance to functionalities that were otherwise prone to reduction, such as sulfones, esters, amides, ketones, nitriles, alkenes and benzyl ethers. The green nature of the reaction was exemplified by the use of PMHS, CPME and a lack of column chromatog.

Green Chemistry published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Name: 2-Fluoro-3-(hydroxymethyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Schirrmacher, Ralf; Wangler, Bjorn; Schirrmacher, Esther; August, Thorsten; Rosch, Frank published the artcile< Dimethylpyridin-4-ylamine-catalysed alcoholysis of 2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride: An effective route to O6-substituted guanine derivatives from alcohols with poor nucleophilicity>, Name: 2-Fluoro-3-(hydroxymethyl)pyridine, the main research area is dimethylpyridinylamine catalyzed alcoholysis nucleophilicity aminotrimethylpurinylammonium chloride; guanine alc derivative preparation.

Dimethylpyridin-4-ylamine (DMAP)-catalyzed reactions of 2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride with fluoropyridine methoxides and various other alkoxides in DMSO at 60 °C gave the corresponding coupling products in moderate to good yields between 20-87%. Under these reaction conditions, fluorinated O6-substituted Guanine derivatives have been synthesized which could not be obtained via known analogous literature procedures. The resp. yields of known O6-substituted guanine derivatives could be significantly improved by using this method. The efficient use of DMAP as an excellent nucleophilic catalyst in the syntheses of O6-substituted Guanine derivatives has thus been demonstrated.

Synthesis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Name: 2-Fluoro-3-(hydroxymethyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pesti, Jaan A.; Huhn, George F.; Yin, Jianguo; Xing, Yide; Fortunak, Joseph M.; Earl, Richard A. published the artcile< Efficient Pyridinylmethyl Functionalization: Synthesis of 10,10-Bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone (DMP 543), an Acetylcholine Release Enhancing Agent>, COA of Formula: C6H6FNO, the main research area is methylpyridine chlorination; pyridylmethyl methanesulfonate preparation alkylation reagent; fluoropyridinylmethylanthrone preparation; anthrone bisfluoropyridinylmethyl preparation.

2-Fluoro-4-methylpyridine is efficiently functionalized by chlorination, hydrolysis and methanesulfonylation into the novel alkylating agent 2-Fluoro-4-methanesulfonylmethylpyridine. This mesylate is used for the bisalkylation of anthrone under carefully defined conditions to prepare the title compound, a cognition enhancer drug candidate. This process proceeds in up to 37% overall yield and is adaptable for large scale synthesis. The chlorination of other methylpyridines was also investigated.

Journal of Organic Chemistry published new progress about Chlorination. 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, COA of Formula: C6H6FNO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bennasar, M.-Lluiesa; Zulaica, Ester; Juan, Cecilia; Alonso, Yolanda; Bosch, Joan published the artcile< Addition of Ester Enolates to N-Alkyl-2-fluoropyridinium Salts: Total Synthesis of (±)-20-Deoxycamptothecin and (+)-Camptothecin>, Related Products of 131747-55-2, the main research area is ester enolate addition fluoropyridinium salt; deoxycamptothecin total synthesis; camptothecin total synthesis.

Several 4-substituted dihydropyridones or 2-pyridones have been prepared by nucleophilic addition of α-(methylsulfanyl)ester enolates to N-alkyl-2-fluoropyridinium salts, followed by acid hydrolysis or oxidation with concomitant hydrolysis, of the intermediate 2-fluoro-1,4-dihydropyridine adducts, resp. Addition of the enolate derived from iso-Pr α-(methylsulfanyl)butyrate to N-(quinolylmethyl)-2-fluoropyridinium triflate followed by DDQ treatment gave a pyridone I, from which (±)-20-deoxycamptothecin a known precursor of camptothecin was synthesized by a radical cyclization-desulfurization, with subsequent elaboration of the lactone E ring by chemoselective reduction A similar sequence starting from the enolate of a chiral 2-hydroxybutyric acid derivative (II) provides access to natural (+)-camptothecin.

Journal of Organic Chemistry published new progress about Addition reaction. 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Related Products of 131747-55-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ashimori, Atsuyuki; Ono, Taizo; Uchida, Takeshi; Ohtaki, Yutaka; Fukaya, Chikara; Watanabe, Masahiro; Yokoyama, Kazumasa published the artcile< Novel 1,4-dihydropyridine calcium antagonists. I. Synthesis and hypotensive activity of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives>, Application In Synthesis of 131747-55-2, the main research area is antihypertensive pyridyldihydropyridinedicarboxylate; pyridyldihydropyridine derivative hypotensive activity; calcium antagonist pyridyldihydropyridinedicarboxylate.

A series of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives I (R = H, halo, CF3, etc.) were synthesized and their hypotensive effects examined Several compounds have a hypotensive activity parallel to that of nicardipine; the 4-(3-trifluoromethyl-2-pyridyl) and 4-(2-trifluoromethyl-3-pyridyl) derivatives, in particular, had approx. twice the duration of nicardipine, and the 4-(4-cyano-2-pyridyl) derivative had the most potent hypotensive activity of all the derivatives synthesized.

Chemical & Pharmaceutical Bulletin published new progress about Antihypertensives. 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Application In Synthesis of 131747-55-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Haixia; Robl, Jeffrey A.; Hamann, Lawrence G.; Simpkins, Ligaya; Golla, Rajasree; Li, Yi-Xin; Seethala, Ramakrishna; Zvyaga, Tatyana; Gordon, David A.; Li, James J. published the artcile< Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1)>, Category: pyridine-derivatives, the main research area is triazolopyridine derivative inhibitor human hydroxysteroid dehydrogenase.

A series of pyridyl amide/sulfonamide inhibitors of 11β-HSD-1 were modified to incorporate a novel 1,2,4-triazolopyridine scaffold. Optimization of substituents at the 3 and 8 position of the TZP core, with a special focus on enhancing metabolic stability, resulted in the identification of compound 38 as a potent and metabolically stable inhibitor of the enzyme.

Bioorganic & Medicinal Chemistry Letters published new progress about Antidiabetic agents. 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 131747-55-2, name is 2-Fluoro-3-(hydroxymethyl)pyridine. A new synthetic method of this compound is introduced below., name: 2-Fluoro-3-(hydroxymethyl)pyridine

Dissolve (2-fluoropyridin-3-yl)methanol in 85 mL of dichloromethane.In ice bath for 10 minutes, 21.7 mL (306.04 mmol) of thionyl chloride was slowly added dropwise. The reaction solution changed from yellow to brown and the reaction was completed. The reaction was continued for 2 h with ice bath. The reaction was complete with TLC monitoring. Continue the ice bath for a while and slowly add 100 mL of water. The N2 was blown, and the lye was absorbed into the exhaust gas. The mixture was extracted with methylene chloride (100 mL*3), washed with saturated brine (100 mL), dried over anhydrous MgSO4, and evaporated under reduced pressure to give 7.14 g of a brown liquid, which was used as needed.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 131747-55-2, 2-Fluoro-3-(hydroxymethyl)pyridine.

Reference:
Patent; The Chinese People’s Liberation Army Military Academy Of Medical Sciences Poison Pharmaceutical Institute; Li Song; Zheng Zhibing; Lin Feng; Gong Zehui; Lu Xinqiang; Zhou Xinbo; Zhong Wu; Xiao Junhai; Xie Yunde; Li Xingzhou; Wang Xiaokui; (24 pag.)CN107964011; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 131747-55-2, name is 2-Fluoro-3-(hydroxymethyl)pyridine. A new synthetic method of this compound is introduced below., name: 2-Fluoro-3-(hydroxymethyl)pyridine

Dissolve (2-fluoropyridin-3-yl)methanol in 85 mL of dichloromethane.In ice bath for 10 minutes, 21.7 mL (306.04 mmol) of thionyl chloride was slowly added dropwise. The reaction solution changed from yellow to brown and the reaction was completed. The reaction was continued for 2 h with ice bath. The reaction was complete with TLC monitoring. Continue the ice bath for a while and slowly add 100 mL of water. The N2 was blown, and the lye was absorbed into the exhaust gas. The mixture was extracted with methylene chloride (100 mL*3), washed with saturated brine (100 mL), dried over anhydrous MgSO4, and evaporated under reduced pressure to give 7.14 g of a brown liquid, which was used as needed.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 131747-55-2, 2-Fluoro-3-(hydroxymethyl)pyridine.

Reference:
Patent; The Chinese People’s Liberation Army Military Academy Of Medical Sciences Poison Pharmaceutical Institute; Li Song; Zheng Zhibing; Lin Feng; Gong Zehui; Lu Xinqiang; Zhou Xinbo; Zhong Wu; Xiao Junhai; Xie Yunde; Li Xingzhou; Wang Xiaokui; (24 pag.)CN107964011; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem