Category: 131747-60-9

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 131747-60-9, name is (2-Fluoropyridin-4-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H6FNO

c Preparation of 2-fluoropyridine-4-carbaldehyde: A solution of 5 g (39 mmol) of (2-fluoropyridin-4-yl)methanol in dichloromethane was added dropwise to a solution of 4.6 ml (54 mmol) of oxalyl chloride and 7.6 ml (106 mmol) of dimethyl sulfoxide (DMSO) in 450 ml of dichloromethane at -78 C. and the mixture was stirred for 15 minutes. 24 ml (180 mmol) of triethylamine were then added and the reaction solution was slowly warmed to RT. It was poured onto 500 ml of water and washed once each with 10% strength citric acid (200 ml) and 10% strength sodium carbonate solution. The dichloromethane phase was dried over magnesium sulfate and concentrated under reduced pressure. Yield: 4.60 g (37 mmol), 94%.

With the rapid development of chemical substances, we look forward to future research findings about 131747-60-9.

Reference:
Patent; Aventis Pharma Deutschland GmbH; US6358978; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 131747-60-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 131747-60-9, name is (2-Fluoropyridin-4-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Reference Production Example 5; A mixture of 0.64 g of 2-fluoro-4-pyridinemethanol, 10 ml of chloroform and 2.54 g of Dess-Martin Periodinane (1,1, 1-triacetoxy-l, 1-dihydro-l, 2- benziodoxol-3 (IH) -one) was stirred for 30 minutes at room temperature. A saturated sodium hydrogen carbonate aqueous solution was poured, and the mixture was extracted three times with ethyl acetate. The combined organic layers were dried over magnesium sulfate, then, concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.19 g of 2-fluoropyridine-4-carbaldehyde .1H-NMR (CDCl3) delta: 10.09 (d, J=I.2Hz, IH), 8.49 (d, J=4.9Hz, IH), 7.65-7.62 (m, IH), 7.38-7.36 (m, IH)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 131747-60-9, (2-Fluoropyridin-4-yl)methanol.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; TAKAHASHI, Masaki; IWAKOSHI, Mitsuhiko; IKEGAMI, Hiroshi; WO2010/125985; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem