Category: 131747-61-0

Electric Literature of 131747-61-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 131747-61-0, name is (2-(Trifluoromethyl)pyridin-4-yl)methanol. A new synthetic method of this compound is introduced below.

To a mixture of (2- (trifluoromethyl) pyridin-4-yl) methanol A-2 (400 mg, 2 mmol) in dichloromethane (5mL) was added SOCl2(2mL) slowly at 0 . The reaction mixture wa stirred at 60 for 1 h. The reaction mixture was then quenched with 1 mL saturated aqueous NH4Cl and extracted with ethyl acetate (5mL × 3) . The combined organic extracts were concentrated in vacuo, the residue was purified on silica gel (EtOAc: petroleum ether 1: 5) to give the product as a solid (300 mg, 60 ) MS (ESI) calc?dfor (C7H5ClF3N) [M+H]+: 195.0 found: 195

At the same time, in my other blogs, there are other synthetic methods of this type of compound,131747-61-0, (2-(Trifluoromethyl)pyridin-4-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ARASAPPAN, Ashok; BUNGARD, Christopher James; FRIE, Jessica L.; HAN, Yongxin; HOYT, Scott B.; MANLEY, Peter J.; MEISSNER, Robert S.; PERKINS, James; SEBHAT, Iyassu K.; WILKENING, Robert R.; (140 pag.)WO2016/29454; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 131747-61-0, (2-(Trifluoromethyl)pyridin-4-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 131747-61-0, blongs to pyridine-derivatives compound. Recommanded Product: (2-(Trifluoromethyl)pyridin-4-yl)methanol

534 tert-Butyl N-[(3-hydroxyphenyl)methyl]carbamate (0.18 g, 1.0 mmol), E-1 (0.22 g, 1.0 mmol) and 13 triphenylphosphine (0.39 g, 1.5 mmol) were dissolved in 12 dichloromethane (3 mL), 236diisopropyl azodicarboxylate (0.32 mL, 1.5 mmol) was added, and the mixture was stirred at roomtemperature for 1 hr. The reaction mixture was concentrated under reduced pressure and the obtained residuewas purified by silica gel column chromatography (hexane/ethyl acetate). To the obtained compound wasadded 4 mol/L 114 hydrochloric acid (1,4-dioxane solution, 3 mL), and the mixture was stirred at roomtemperature for 1 hr, and concentrated under reduced pressure to give the 535 title compound ( 0.13 g ,0.40 mmol, 40%) MS (ESI) m/z 283 (M+H)+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,131747-61-0, its application will become more common.

Reference:
Patent; EA PHARMA CO., LTD.; KOBAYASHI, Kaori; SUZUKI, Tamotsu; KAWAHIRA, Mizuki; FUJII, Tomohiro; SUGIKI, Masayuki; OHSUMI, Koji; OKUZUMI, Tatsuya; (285 pag.)US2016/332999; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem